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Nobiletin induces inhibitions of Ras activity and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling to suppress cell proliferation in C6 rat glioma cells.
Aoki K, Yokosuka A, Mimaki Y, Fukunaga K, Yamakuni T. Aoki K, et al. Among authors: mimaki y. Biol Pharm Bull. 2013;36(4):540-7. doi: 10.1248/bpb.b12-00824. Biol Pharm Bull. 2013. PMID: 23546290
Urinary metabolites of nobiletin orally administered to rats.
Yasuda T, Yoshimura Y, Yabuki H, Nakazawa T, Ohsawa K, Mimaki Y, Sashida Y. Yasuda T, et al. Among authors: mimaki y. Chem Pharm Bull (Tokyo). 2003 Dec;51(12):1426-8. doi: 10.1248/cpb.51.1426. Chem Pharm Bull (Tokyo). 2003. PMID: 14646323
Mechanism of neurotrophic action of nobiletin in PC12D cells.
Nagase H, Yamakuni T, Matsuzaki K, Maruyama Y, Kasahara J, Hinohara Y, Kondo S, Mimaki Y, Sashida Y, Tank AW, Fukunaga K, Ohizumi Y. Nagase H, et al. Among authors: mimaki y. Biochemistry. 2005 Oct 25;44(42):13683-91. doi: 10.1021/bi050643x. Biochemistry. 2005. PMID: 16229458
Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities.
Nagase H, Omae N, Omori A, Nakagawasai O, Tadano T, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y. Nagase H, et al. Among authors: mimaki y. Biochem Biophys Res Commun. 2005 Dec 2;337(4):1330-6. doi: 10.1016/j.bbrc.2005.10.001. Epub 2005 Oct 10. Biochem Biophys Res Commun. 2005. PMID: 16253614
Nobiletin restoring beta-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats.
Matsuzaki K, Yamakuni T, Hashimoto M, Haque AM, Shido O, Mimaki Y, Sashida Y, Ohizumi Y. Matsuzaki K, et al. Among authors: mimaki y. Neurosci Lett. 2006 Jun 12;400(3):230-4. doi: 10.1016/j.neulet.2006.02.077. Epub 2006 Apr 3. Neurosci Lett. 2006. PMID: 16581185
Nobiletin, a citrus flavonoid, reverses learning impairment associated with N-methyl-D-aspartate receptor antagonism by activation of extracellular signal-regulated kinase signaling.
Nakajima A, Yamakuni T, Matsuzaki K, Nakata N, Onozuka H, Yokosuka A, Sashida Y, Mimaki Y, Ohizumi Y. Nakajima A, et al. Among authors: mimaki y. J Pharmacol Exp Ther. 2007 May;321(2):784-90. doi: 10.1124/jpet.106.117010. Epub 2007 Feb 8. J Pharmacol Exp Ther. 2007. PMID: 17289833
Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice.
Nakajima A, Yamakuni T, Haraguchi M, Omae N, Song SY, Kato C, Nakagawasai O, Tadano T, Yokosuka A, Mimaki Y, Sashida Y, Ohizumi Y. Nakajima A, et al. Among authors: mimaki y. J Pharmacol Sci. 2007 Sep;105(1):122-6. doi: 10.1254/jphs.sc0070155. J Pharmacol Sci. 2007. PMID: 17895593
Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus.
Matsuzaki K, Miyazaki K, Sakai S, Yawo H, Nakata N, Moriguchi S, Fukunaga K, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y. Matsuzaki K, et al. Among authors: mimaki y. Eur J Pharmacol. 2008 Jan 14;578(2-3):194-200. doi: 10.1016/j.ejphar.2007.09.028. Epub 2007 Oct 2. Eur J Pharmacol. 2008. PMID: 17976577
Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease.
Onozuka H, Nakajima A, Matsuzaki K, Shin RW, Ogino K, Saigusa D, Tetsu N, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y. Onozuka H, et al. Among authors: mimaki y. J Pharmacol Exp Ther. 2008 Sep;326(3):739-44. doi: 10.1124/jpet.108.140293. Epub 2008 Jun 10. J Pharmacol Exp Ther. 2008. PMID: 18544674
Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.
Yamamoto Y, Shioda N, Han F, Moriguchi S, Nakajima A, Yokosuka A, Mimaki Y, Sashida Y, Yamakuni T, Ohizumi Y, Fukunaga K. Yamamoto Y, et al. Among authors: mimaki y. Brain Res. 2009 Oct 27;1295:218-29. doi: 10.1016/j.brainres.2009.07.081. Epub 2009 Jul 30. Brain Res. 2009. PMID: 19646972
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