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Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2.
Xu W, Mimnaugh EG, Kim JS, Trepel JB, Neckers LM. Xu W, et al. Among authors: mimnaugh eg. Cell Stress Chaperones. 2002 Jan;7(1):91-6. doi: 10.1379/1466-1268(2002)007<0091:hngrti>;2. Cell Stress Chaperones. 2002. PMID: 11892991 Free PMC article.
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway.
Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM. Isaacs JS, et al. Among authors: mimnaugh eg. J Biol Chem. 2002 Aug 16;277(33):29936-44. doi: 10.1074/jbc.M204733200. Epub 2002 Jun 6. J Biol Chem. 2002. PMID: 12052835 Free article.
Endoplasmic reticulum vacuolization and valosin-containing protein relocalization result from simultaneous hsp90 inhibition by geldanamycin and proteasome inhibition by velcade.
Mimnaugh EG, Xu W, Vos M, Yuan X, Neckers L. Mimnaugh EG, et al. Mol Cancer Res. 2006 Sep;4(9):667-81. doi: 10.1158/1541-7786.MCR-06-0019. Mol Cancer Res. 2006. PMID: 16966435 Free article.
Measuring ubiquitin conjugation in cells.
Mimnaugh EG, Neckers LM. Mimnaugh EG, et al. Methods Mol Biol. 2005;301:223-41. doi: 10.1385/1-59259-895-1:223. Methods Mol Biol. 2005. PMID: 15917635
Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.
Mimnaugh EG, Xu W, Vos M, Yuan X, Isaacs JS, Bisht KS, Gius D, Neckers L. Mimnaugh EG, et al. Mol Cancer Ther. 2004 May;3(5):551-66. Mol Cancer Ther. 2004. PMID: 15141013 Free article.
Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.
Xu W, Yuan X, Xiang Z, Mimnaugh E, Marcu M, Neckers L. Xu W, et al. Among authors: mimnaugh e. Nat Struct Mol Biol. 2005 Feb;12(2):120-6. doi: 10.1038/nsmb885. Epub 2005 Jan 9. Nat Struct Mol Biol. 2005. PMID: 15643424
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu.
Xu W, Marcu M, Yuan X, Mimnaugh E, Patterson C, Neckers L. Xu W, et al. Among authors: mimnaugh e. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12847-52. doi: 10.1073/pnas.202365899. Epub 2002 Sep 18. Proc Natl Acad Sci U S A. 2002. PMID: 12239347 Free PMC article.
Hsp90 as an anti-cancer target.
Neckers L, Mimnaugh E, Schulte TW. Neckers L, et al. Drug Resist Updat. 1999 Jun;2(3):165-172. doi: 10.1054/drup.1999.0082. Drug Resist Updat. 1999. PMID: 11504487
17AAG: low target binding affinity and potent cell activity--finding an explanation.
Chiosis G, Huezo H, Rosen N, Mimnaugh E, Whitesell L, Neckers L. Chiosis G, et al. Among authors: mimnaugh e. Mol Cancer Ther. 2003 Feb;2(2):123-9. Mol Cancer Ther. 2003. PMID: 12589029 Free article.
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