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Page 1
Did you mean mind (101,127 results)?
Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood-brain barrier.
Kopel JJ, Bhutia YD, Sivaprakasam S, Ganapathy V. Kopel JJ, et al. Biochem J. 2021 Feb 12;478(3):463-486. doi: 10.1042/BCJ20200877. Biochem J. 2021. PMID: 33544126 Free PMC article. Review.
NaCT/SLC13A5 is a Na+-coupled transporter for citrate in hepatocytes, neurons, and testes. It is also called mINDY (mammalian ortholog of 'I'm Not Dead Yet' in Drosophila). Deletion of Slc13a5 in mice leads to an advantageous phenotype, protecting against diet-induced obes …
NaCT/SLC13A5 is a Na+-coupled transporter for citrate in hepatocytes, neurons, and testes. It is also called mINDY (mammalian ortholo …
The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms.
Willmes DM, Daniels M, Kurzbach A, Lieske S, Bechmann N, Schumann T, Henke C, El-Agroudy NN, Da Costa Goncalves AC, Peitzsch M, Hofmann A, Kanczkowski W, Kräker K, Müller DN, Morawietz H, Deussen A, Wagner M, El-Armouche A, Helfand SL, Bornstein SR, de Cabo R, Bernier M, Eisenhofer G, Tank J, Jordan J, Birkenfeld AL. Willmes DM, et al. JCI Insight. 2021 Jan 25;6(2):e136083. doi: 10.1172/jci.insight.136083. JCI Insight. 2021. PMID: 33491666 Free PMC article.
We hypothesized that mIndy deletion attenuates sympathoadrenal support of BP. Continuous arterial BP and heart rate (HR) were reduced in mINDY-KO mice. ...Catecholamine biosynthesis pathways were reduced in mINDY-KO adrenals using unbiased microarray analysis …
We hypothesized that mIndy deletion attenuates sympathoadrenal support of BP. Continuous arterial BP and heart rate (HR) were reduced …
MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes.
Abdul Rehman SA, Kristariyanto YA, Choi SY, Nkosi PJ, Weidlich S, Labib K, Hofmann K, Kulathu Y. Abdul Rehman SA, et al. Mol Cell. 2016 Jul 7;63(1):146-55. doi: 10.1016/j.molcel.2016.05.009. Epub 2016 Jun 9. Mol Cell. 2016. PMID: 27292798 Free PMC article.
Here we report the discovery of a new family of DUBs, which we have named MINDY (motif interacting with Ub-containing novel DUB family). Found in all eukaryotes, MINDY-family DUBs are highly selective at cleaving K48-linked polyUb, a signal that targets proteins for …
Here we report the discovery of a new family of DUBs, which we have named MINDY (motif interacting with Ub-containing novel DUB famil …
Genome Sequence of Mycobacteriophage Mindy.
Pope WH, Bernstein NI, Fasolas CS, Mezghani N, Pressimone CA, Selvakumar P, Stanton AC, Lapin JS, Prout AK, Grubb SR, Warner MH, Bowman CA, Russell DA, Hatfull GF. Pope WH, et al. Genome Announc. 2015 Jun 18;3(3):e00596-15. doi: 10.1128/genomeA.00596-15. Genome Announc. 2015. PMID: 26089411 Free PMC article.
Mycobacteriophage Mindy is a newly isolated phage of Mycobacterium smegmatis, recovered from a soil sample in Pittsburgh, Pennsylvania, USA. Mindy has a genome length of 75,796 bp, encodes 147 predicted proteins and two tRNAs, and is closely related to mycobacteriop …
Mycobacteriophage Mindy is a newly isolated phage of Mycobacterium smegmatis, recovered from a soil sample in Pittsburgh, Pennsylvani …
Arylhydrocarbon receptor-dependent mIndy (Slc13a5) induction as possible contributor to benzo[a]pyrene-induced lipid accumulation in hepatocytes.
Neuschäfer-Rube F, Schraplau A, Schewe B, Lieske S, Krützfeldt JM, Ringel S, Henkel J, Birkenfeld AL, Püschel GP. Neuschäfer-Rube F, et al. Toxicology. 2015 Nov 4;337:1-9. doi: 10.1016/j.tox.2015.08.007. Epub 2015 Aug 21. Toxicology. 2015. PMID: 26303333
Elimination or mutation of this site largely abolished the activation of the mINDY promoter by benzo[a]pyrene. This study thus identified the mINDY as an AhR target gene. AhR-dependent induction of the mINDY gene might contribute to the development of hepatic …
Elimination or mutation of this site largely abolished the activation of the mINDY promoter by benzo[a]pyrene. This study thus identi …
A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains.
Kristariyanto YA, Abdul Rehman SA, Weidlich S, Knebel A, Kulathu Y. Kristariyanto YA, et al. EMBO Rep. 2017 Mar;18(3):392-402. doi: 10.15252/embr.201643205. Epub 2017 Jan 12. EMBO Rep. 2017. PMID: 28082312 Free PMC article.
The motif interacting with ubiquitin (MIU) is a small UBD that has been characterized for its binding to monoUb. The recently discovered deubiquitinase MINDY-1/FAM63A contains a tandem MIU repeat (tMIU) that is highly selective at binding to K48-linked polyUb. We here iden …
The motif interacting with ubiquitin (MIU) is a small UBD that has been characterized for its binding to monoUb. The recently discovered deu …
The longevity gene INDY (I'm Not Dead Yet) in metabolic control: Potential as pharmacological target.
Willmes DM, Kurzbach A, Henke C, Schumann T, Zahn G, Heifetz A, Jordan J, Helfand SL, Birkenfeld AL. Willmes DM, et al. Pharmacol Ther. 2018 May;185:1-11. doi: 10.1016/j.pharmthera.2017.10.003. Epub 2017 Oct 5. Pharmacol Ther. 2018. PMID: 28987323 Free article. Review.
Moreover, we have shown that inducible and liver selective knock down of mIndy protects against the development of fatty liver and insulin resistance and that obese humans with type 2 diabetes and non-alcoholic fatty liver disease have increased levels of mIndy. The …
Moreover, we have shown that inducible and liver selective knock down of mIndy protects against the development of fatty liver and in …
Monogenic Lupus.
Lo MS. Lo MS. Curr Rheumatol Rep. 2016 Dec;18(12):71. doi: 10.1007/s11926-016-0621-9. Curr Rheumatol Rep. 2016. PMID: 27812953 Review.
The Role of INDY in Metabolic Regulation.
Willmes DM, Birkenfeld AL. Willmes DM, et al. Comput Struct Biotechnol J. 2013 Dec 8;6:e201303020. doi: 10.5936/csbj.201303020. eCollection 2013. Comput Struct Biotechnol J. 2013. PMID: 24688728 Free PMC article. Review.
Deletion of mINDY in mice leads to significant metabolic changes akin to caloric restriction, likely caused by reducing the effects of mINDY-imported citrate on fatty acid and cholesterol synthesis, glucose metabolism and ss-oxidation. This review will provide an ov …
Deletion of mINDY in mice leads to significant metabolic changes akin to caloric restriction, likely caused by reducing the effects o …
MDAI (5,6-methylenedioxy-2-aminoindane; 6,7-dihydro-5H-cyclopenta[f][1,3]benzodioxol-6-amine; 'sparkle'; 'mindy') toxicity: a brief overview and update.
Corkery JM, Elliott S, Schifano F, Corazza O, Ghodse AH. Corkery JM, et al. Hum Psychopharmacol. 2013 Jul;28(4):345-55. doi: 10.1002/hup.2298. Hum Psychopharmacol. 2013. PMID: 23881883 Review.
OBJECTIVES: MDAI (5,6-methylenedioxy-2-aminoindane; 6,7-dihydro-5H-cyclopenta[f][1,3]benzodioxol-6-amine; 'sparkle'; 'mindy') is a psychoactive substance, sold primarily over the Internet and in 'head' shops as a 'legal high'. ...
OBJECTIVES: MDAI (5,6-methylenedioxy-2-aminoindane; 6,7-dihydro-5H-cyclopenta[f][1,3]benzodioxol-6-amine; 'sparkle'; 'mindy') is a ps …
236 results