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The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
Pelletier JP, Boileau C, Boily M, Brunet J, Mineau F, Geng C, Reboul P, Laufer S, Lajeunesse D, Martel-Pelletier J. Pelletier JP, et al. Among authors: mineau f. Arthritis Res Ther. 2005;7(5):R1091-102. doi: 10.1186/ar1788. Epub 2005 Jul 19. Arthritis Res Ther. 2005. PMID: 16207326 Free PMC article.
Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids.
Martel-Pelletier J, Mineau F, Fahmi H, Laufer S, Reboul P, Boileau C, Lavigne M, Pelletier JP. Martel-Pelletier J, et al. Among authors: mineau f. Arthritis Rheum. 2004 Dec;50(12):3925-33. doi: 10.1002/art.20632. Arthritis Rheum. 2004. PMID: 15593193 Free article.
The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and catabolic pathways.
Boileau C, Martel-Pelletier J, Fahmi H, Mineau F, Boily M, Pelletier JP. Boileau C, et al. Among authors: mineau f. Arthritis Rheum. 2007 Jul;56(7):2288-98. doi: 10.1002/art.22726. Arthritis Rheum. 2007. PMID: 17599749 Free article.
Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study.
Martel-Pelletier J, Raynauld JP, Mineau F, Abram F, Paiement P, Delorme P, Pelletier JP. Martel-Pelletier J, et al. Among authors: mineau f. Arthritis Res Ther. 2017 Jul 20;19(1):169. doi: 10.1186/s13075-017-1377-y. Arthritis Res Ther. 2017. PMID: 28728606 Free PMC article. Clinical Trial.
35 results