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Page 1
Sirtuin-1 directly binds and deacetylates hepatic PCSK9 thereby promoting the inhibition of LDL receptor degradation.
Velagapudi S, Miranda MX, Adla P, Kraler S, Mohammed SA, Baki S, Robert J, Rohrer L, Lee H, Jang HD, Obeid S, Tailleux A, Staels B, Sepuri NBV, Paneni F, Gutti RK, von Eckardstein A, Kim HS, Akhmedov A, Camici GG, Lüscher TF. Velagapudi S, et al. Among authors: miranda mx. Cardiovasc Res. 2025 Aug 14;121(9):1373-1384. doi: 10.1093/cvr/cvaf087. Cardiovasc Res. 2025. PMID: 40653676 Free PMC article.
Sirtuin 5 promotes arterial thrombosis by blunting the fibrinolytic system.
Liberale L, Akhmedov A, Vlachogiannis NI, Bonetti NR, Nageswaran V, Miranda MX, Puspitasari YM, Schwarz L, Costantino S, Paneni F, Beer JH, Ruschitzka F, Montecucco F, Lüscher TF, Stamatelopoulos K, Stellos K, Camici GG. Liberale L, et al. Among authors: miranda mx. Cardiovasc Res. 2021 Aug 29;117(10):2275-2288. doi: 10.1093/cvr/cvaa268. Cardiovasc Res. 2021. PMID: 32931562 Free article.
Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1.
Arsiwala T, Pahla J, van Tits LJ, Bisceglie L, Gaul DS, Costantino S, Miranda MX, Nussbaum K, Stivala S, Blyszczuk P, Weber J, Tailleux A, Stein S, Paneni F, Beer JH, Greter M, Becher B, Mostoslavsky R, Eriksson U, Staels B, Auwerx J, Hottiger MO, Lüscher TF, Matter CM. Arsiwala T, et al. Among authors: miranda mx. J Mol Cell Cardiol. 2020 Feb;139:24-32. doi: 10.1016/j.yjmcc.2020.01.002. Epub 2020 Jan 21. J Mol Cell Cardiol. 2020. PMID: 31972266
Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.
O'Flaherty L, Adam J, Heather LC, Zhdanov AV, Chung YL, Miranda MX, Croft J, Olpin S, Clarke K, Pugh CW, Griffiths J, Papkovsky D, Ashrafian H, Ratcliffe PJ, Pollard PJ. O'Flaherty L, et al. Among authors: miranda mx. Hum Mol Genet. 2010 Oct 1;19(19):3844-51. doi: 10.1093/hmg/ddq305. Epub 2010 Jul 21. Hum Mol Genet. 2010. PMID: 20660115 Free PMC article.
The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.
Miranda MX, van Tits LJ, Lohmann C, Arsiwala T, Winnik S, Tailleux A, Stein S, Gomes AP, Suri V, Ellis JL, Lutz TA, Hottiger MO, Sinclair DA, Auwerx J, Schoonjans K, Staels B, Lüscher TF, Matter CM. Miranda MX, et al. Eur Heart J. 2015 Jan 1;36(1):51-9. doi: 10.1093/eurheartj/ehu095. Epub 2014 Mar 6. Eur Heart J. 2015. PMID: 24603306 Free PMC article.
Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development.
Winnik S, Gaul DS, Preitner F, Lohmann C, Weber J, Miranda MX, Liu Y, van Tits LJ, Mateos JM, Brokopp CE, Auwerx J, Thorens B, Lüscher TF, Matter CM. Winnik S, et al. Among authors: miranda mx. Basic Res Cardiol. 2014 Jan;109(1):399. doi: 10.1007/s00395-013-0399-0. Epub 2013 Dec 27. Basic Res Cardiol. 2014. PMID: 24370889 Free PMC article.
Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors.
Li XS, Obeid S, Klingenberg R, Gencer B, Mach F, Räber L, Windecker S, Rodondi N, Nanchen D, Muller O, Miranda MX, Matter CM, Wu Y, Li L, Wang Z, Alamri HS, Gogonea V, Chung YM, Tang WH, Hazen SL, Lüscher TF. Li XS, et al. Among authors: miranda mx. Eur Heart J. 2017 Mar 14;38(11):814-824. doi: 10.1093/eurheartj/ehw582. Eur Heart J. 2017. PMID: 28077467 Free PMC article.