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Sialylation-dependent pharmacokinetics and differential complement pathway inhibition are hallmarks of CR1 activity in vivo.
Wymann S, Mischnik M, Leong D, Ghosh S, Tan X, Cao H, Kuehnemuth B, Powers GA, Halder P, de Souza MJ, James HS, Tomasetig V, Lind H, Rossato P, Owczarek CM, Ow SY, Dower SK, Baz Morelli A, Rowe T, Hardy MP. Wymann S, et al. Among authors: mischnik m. Biochem J. 2022 May 13;479(9):1007-1030. doi: 10.1042/BCJ20220054. Biochem J. 2022. PMID: 35470373
Plasma-Derived Hemopexin as a Candidate Therapeutic Agent for Acute Vaso-Occlusion in Sickle Cell Disease: Preclinical Evidence.
Gentinetta T, Belcher JD, Brügger-Verdon V, Adam J, Ruthsatz T, Bain J, Schu D, Ventrici L, Edler M, Lioe H, Patel K, Chen C, Nguyen J, Abdulla F, Zhang P, Wassmer A, Jain M, Mischnik M, Pelzing M, Martin K, Davis R, Didichenko S, Schaub A, Brinkman N, Herzog E, Zürcher A, Vercellotti GM, Kato GJ, Höbarth G. Gentinetta T, et al. Among authors: mischnik m. J Clin Med. 2022 Jan 26;11(3):630. doi: 10.3390/jcm11030630. J Clin Med. 2022. PMID: 35160081 Free PMC article.
Increased potency of recombinant VWF D'D3 albumin fusion proteins engineered for enhanced affinity for coagulation factor VIII.
Chia J, Pestel S, Glauser I, Emmrich K, Hardy MP, Mischnik M, Raquet E, Tomasetig V, Claar P, Zalewski A, Bass GT, Turnbull V, Chen CG, Wilson MJ, Panousis C, Weimer T, Andrews A, Verhagen AM, Dower SK. Chia J, et al. Among authors: mischnik m. J Thromb Haemost. 2021 Nov;19(11):2710-2725. doi: 10.1111/jth.15480. Epub 2021 Aug 17. J Thromb Haemost. 2021. PMID: 34333849 Free article.
A novel soluble complement receptor 1 fragment with enhanced therapeutic potential.
Wymann S, Dai Y, Nair AG, Cao H, Powers GA, Schnell A, Martin-Roussety G, Leong D, Simmonds J, Lieu KG, de Souza MJ, Mischnik M, Taylor S, Ow SY, Spycher M, Butcher RE, Pearse M, Zuercher AW, Baz Morelli A, Panousis C, Wilson MJ, Rowe T, Hardy MP. Wymann S, et al. Among authors: mischnik m. J Biol Chem. 2021 Jan-Jun;296:100200. doi: 10.1074/jbc.RA120.016127. Epub 2020 Dec 23. J Biol Chem. 2021. PMID: 33334893 Free PMC article.
13 results