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PEGylated carboxyhemoglobin bovine (SANGUINATE): results of a phase I clinical trial.
Misra H, Lickliter J, Kazo F, Abuchowski A. Misra H, et al. Artif Organs. 2014 Aug;38(8):702-7. doi: 10.1111/aor.12341. Epub 2014 Aug 12. Artif Organs. 2014. PMID: 25113835 Clinical Trial.
The T1/2 was dose dependent and ranged from 7.9 to 13.8 h. In addition to the Phase I trial, SANGUINATE was used under an expanded access emergency Investigational New Drug. ...
The T1/2 was dose dependent and ranged from 7.9 to 13.8 h. In addition to the Phase I trial, SANGUINATE was used under an expanded ac …
A phase Ib, open-label, single arm study to assess the safety, pharmacokinetics, and impact on humoral sensitization of SANGUINATE infusion in patients with end-stage renal disease.
Abu Jawdeh BG, Woodle ES, Leino AD, Brailey P, Tremblay S, Dorst T, Abdallah MH, Govil A, Byczkowski D, Misra H, Abuchowski A, Alloway RR. Abu Jawdeh BG, et al. Clin Transplant. 2018 Jan;32(1). doi: 10.1111/ctr.13155. Epub 2017 Dec 4. Clin Transplant. 2018. PMID: 29140548 Clinical Trial.
SG pharmacokinetic analysis showed mean (SD) C(max) , T(max) , AUC, and half-life of 4.39 (0.69) mg/mL, 2.42 (0.91) hours, 171.86 (52.35) mg h/mL, and 40.60 (11.96) hours, respectively. ...
SG pharmacokinetic analysis showed mean (SD) C(max) , T(max) , AUC, and half-life of 4.39 (0.69) mg/mL, 2.42 (0.91) hours, 171.86 (52.35) mg …
A Phase I study to determine safety, pharmacokinetics, and pharmacodynamics of ANF-RHO™, a novel PEGylated granulocyte colony-stimulating factor, in healthy volunteers.
Misra H, Berryman J, Jubin R, Abuchowski A. Misra H, et al. Invest New Drugs. 2018 Feb;36(1):75-84. doi: 10.1007/s10637-017-0490-8. Epub 2017 Jul 28. Invest New Drugs. 2018. PMID: 28752433 Clinical Trial.
SANGUINATE™ (PEGylated Carboxyhemoglobin Bovine) Improves Cerebral Blood Flow to Vulnerable Brain Regions at Risk of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage.
Dhar R, Misra H, Diringer MN. Dhar R, et al. Neurocrit Care. 2017 Dec;27(3):341-349. doi: 10.1007/s12028-017-0418-3. Neurocrit Care. 2017. PMID: 28639001
RESULTS: SANGUINATE resulted in a transient rise in mean arterial pressure (116 ± 15-127 ± 13 mm Hg, p = 0.001) that normalized by 24 h and allowed three patients with DCI to be weaned off vasopressors. ...However, a significant 16% rise in regional CBF associated with red …
RESULTS: SANGUINATE resulted in a transient rise in mean arterial pressure (116 ± 15-127 ± 13 mm Hg, p = 0.001) that normalized by 24 h
A Phase Ib open label, randomized, safety study of SANGUINATE™ in patients with sickle cell anemia.
Misra H, Bainbridge J, Berryman J, Abuchowski A, Galvez KM, Uribe LF, Hernandez AL, Sosa NR. Misra H, et al. Rev Bras Hematol Hemoter. 2017 Jan-Mar;39(1):20-27. doi: 10.1016/j.bjhh.2016.08.004. Epub 2016 Oct 20. Rev Bras Hematol Hemoter. 2017. PMID: 28270341 Free PMC article.
The Bromodomain Protein 4 Contributes to the Regulation of Alternative Splicing.
Uppal S, Gegonne A, Chen Q, Thompson PS, Cheng D, Mu J, Meerzaman D, Misra HS, Singer DS. Uppal S, et al. Among authors: misra hs. Cell Rep. 2019 Nov 19;29(8):2450-2460.e5. doi: 10.1016/j.celrep.2019.10.066. Cell Rep. 2019. PMID: 31747612 Free PMC article.
MusaMPK5, a mitogen activated protein kinase is involved in regulation of cold tolerance in banana.
Tak H, Negi S, Rajpurohit YS, Misra HS, Ganapathi TR. Tak H, et al. Among authors: misra hs. Plant Physiol Biochem. 2020 Jan;146:112-123. doi: 10.1016/j.plaphy.2019.11.012. Epub 2019 Nov 7. Plant Physiol Biochem. 2020. PMID: 31739146
Depressive symptoms and the risk of arthritis: A survival analysis using data from the osteoarthritis initiative.
Vennu V, Misra H, Misra A. Vennu V, et al. Among authors: misra h. Indian J Psychiatry. 2019 Sep-Oct;61(5):444-450. doi: 10.4103/psychiatry.IndianJPsychiatry_241_18. Indian J Psychiatry. 2019. PMID: 31579152 Free PMC article.
Guanine Quadruplex DNA Regulates Gamma Radiation Response of Genome Functions in the Radioresistant Bacterium Deinococcus radiodurans.
Mishra S, Chaudhary R, Singh S, Kota S, Misra HS. Mishra S, et al. Among authors: misra hs. J Bacteriol. 2019 Aug 8;201(17):e00154-19. doi: 10.1128/JB.00154-19. Print 2019 Sep 1. J Bacteriol. 2019. PMID: 31235513 Free PMC article.
Characterisation of ParB encoded on multipartite genome in Deinococcus radiodurans and their roles in radioresistance.
Maurya GK, Kota S, Misra HS. Maurya GK, et al. Among authors: misra hs. Microbiol Res. 2019 Jun-Aug;223-225:22-32. doi: 10.1016/j.micres.2019.03.005. Epub 2019 Apr 1. Microbiol Res. 2019. PMID: 31178048 Free article.
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