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Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity.
Iida T, Ubukata M, Mitani I, Nakagawa Y, Maeda K, Imai H, Ogoshi Y, Hotta T, Sakata S, Sano R, Morinaga H, Negoro T, Oshida S, Tanaka M, Inaba T. Iida T, et al. Among authors: mitani i. Eur J Med Chem. 2018 Oct 5;158:832-852. doi: 10.1016/j.ejmech.2018.09.003. Eur J Med Chem. 2018. PMID: 30248655
Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents.
Hayden FG, Sugaya N, Hirotsu N, Lee N, de Jong MD, Hurt AC, Ishida T, Sekino H, Yamada K, Portsmouth S, Kawaguchi K, Shishido T, Arai M, Tsuchiya K, Uehara T, Watanabe A; Baloxavir Marboxil Investigators Group. Hayden FG, et al. N Engl J Med. 2018 Sep 6;379(10):913-923. doi: 10.1056/NEJMoa1716197. N Engl J Med. 2018. PMID: 30184455 Free article. Clinical Trial.
Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia.
Ogoshi Y, Matsui T, Mitani I, Yokota M, Terashita M, Motoda D, Ueyama K, Hotta T, Ito T, Hase Y, Fukui K, Deai K, Yoshiuchi H, Ito S, Abe H. Ogoshi Y, et al. Among authors: mitani i. ACS Med Chem Lett. 2017 Nov 20;8(12):1320-1325. doi: 10.1021/acsmedchemlett.7b00404. eCollection 2017 Dec 14. ACS Med Chem Lett. 2017. PMID: 29259755 Free PMC article.
Clinical value of iodine-123 beta-methyliodophenyl pentadecanoic acid (BMIPP) myocardial single photon emission computed tomography for predicting cardiac death among patients with chronic heart failure.
Sasaki R, Mitani I, Usui T, Kitamura Y, Yoshii Y, Ishikawa T, Uchino K, Takahashi N, Kimura K, Umemura S. Sasaki R, et al. Among authors: mitani i. Circ J. 2003 Nov;67(11):918-24. doi: 10.1253/circj.67.918. Circ J. 2003. PMID: 14578597 Free article. Clinical Trial.
Clinical implications of cardiac (123)I-meta-iodobenzylguanidine scintigraphy and cardiac natriuretic peptides in patients with heart disease.
Ebina T, Takahashi N, Mitani I, Sumita S, Ishigami T, Ashino K, Minamisawa K, Kuji N, Ochiai H, Ishikawa Y, Oka T, Inoue T, Matsubara S, Umemura S. Ebina T, et al. Among authors: mitani i. Nucl Med Commun. 2002 Aug;23(8):795-801. doi: 10.1097/00006231-200208000-00014. Nucl Med Commun. 2002. PMID: 12124486 Clinical Trial.
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