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Asia-Pacific consensus guidelines on gastric cancer prevention
Fock KM, et al. J Gastroenterol Hepatol 2008. Among authors: Mitchell H. PMID 18318820
H. pylori screening and treatment is a recommended gastric cancer risk reduction strategy in high-risk populations. H. pylori screening and treatment is most effective before atrophic gastritis has developed. ...In populations at low risk for gastric cancer, H. pylori screening is not recommended. First-line treatment of H. pylori infection should be in accordance with national treatment guidelines. ...
H. pylori screening and treatment is a recommended gastric cancer risk reduction strategy in high-risk populations. H. pylori
Immunoblotting using multiple antigens is essential to demonstrate the true risk of Helicobacter pylori infection for gastric cancer
Mitchell H, et al. Aliment Pharmacol Ther 2008. PMID 18624791
AIM: To compare associations between H. pylori and cardia (CGC) and noncardia gastric cancer (NCGC) using ELISA and immunoblotting and determine the effect of atrophic gastritis on detection. ...CONCLUSION: Immunoblotting improves the accuracy of H. pylori studies involving gastric cancer....
AIM: To compare associations between H. pylori and cardia (CGC) and noncardia gastric cancer (NCGC) using ELISA and immunoblotting an …
Gastric cancer in sub-Saharan Africa
Segal I, et al. Eur J Cancer Prev 2001 - Review. Among authors: Mitchell H. PMID 11916345
Evidence from Soweto indicates that the host response to H. pylori may be protective against a virulent organism and that, in most people, H. pylori does not lead to more serious sequelae. This suggests that there may be host protective/inhibitory factors present, which prevent the progression of H. pylori-induced chronic active gastritis to cancer....
Evidence from Soweto indicates that the host response to H. pylori may be protective against a virulent organism and that, in most pe …
Gastric atrophy and regional variation in upper gastrointestinal disease
Hu PJ, et al. Am J Gastroenterol 1995. Among authors: Mitchell HM. PMID 7611205
CONCLUSIONS: The prevalence of atrophy, rather than age of acquisition and prevalence of H. pylori infection, appears to be a marker of the major upper gastrointestinal disease profiles of a region. Development of atrophy, although apparently related to H. pylori infection, may be a multifactorial condition. Differences in diet, as seen between Guangzhou and Lanzhou, may be important in this regard. ...
CONCLUSIONS: The prevalence of atrophy, rather than age of acquisition and prevalence of H. pylori infection, appears to be a marker …
Are there ulcerogenic strains of Helicobacter pylori?
Mitchell HM and Lee A. Eur J Gastroenterol Hepatol 1994 - Review. PMID 7735926
CONTROVERSY: Although H. pylori is now well established as a predisposing factor in peptic ulcer disease the question of why only a minority of people infected with H. pylori develop peptic ulceration remains unanswered and is the subject of much controversy. ...CONCLUSION: At the present time the case for ulcerogenic strains is not proven and the differences between H. pylori infected peptic ulcer patients and H. pylori infected non-ulcer subjects may relate simply to host factors....
CONTROVERSY: Although H. pylori is now well established as a predisposing factor in peptic ulcer disease the question of why only a m …
Antral-type mucosa in the gastric incisura, body, and fundus (antralization): a link between Helicobacter pylori infection and intestinal metaplasia?
Xia HH, et al. Am J Gastroenterol 2000. Among authors: Mitchell HM. PMID 10638568
CONCLUSIONS: Atrophic gastritis and intestinal metaplasia occurs predominantly at the gastric antrum and incisura with H. pylori infection. Antralization of the gastric incisura is a common event in H. pylori-infected patients, and appears to be associated with an increased risk of atrophic gastritis and intestinal metaplasia....
CONCLUSIONS: Atrophic gastritis and intestinal metaplasia occurs predominantly at the gastric antrum and incisura with H. pylori infe …
A low rate of reinfection following effective therapy against Helicobacter pylori in a developing nation (China)
Mitchell HM, et al. Gastroenterology 1998. PMID 9453484
High prevalences of H. pylori in developing countries may result in high reinfection rates. The aim of this study was to determine the rate of reinfection and ulcer recurrence in Chinese patients cured of H. pylori and duodenal ulcer disease. ...Ulcer relapse occurred in 6 patients (4 H. pylori positive). CONCLUSIONS: Reinfection with H. pylori is rare in developing countries where treatment is effective....
High prevalences of H. pylori in developing countries may result in high reinfection rates. The aim of this study was to determine th …
Lansoprazole and amoxycillin: observations on the treatment of Helicobacter pylori infection
Hazell SL, et al. J Gastroenterol Hepatol 1997 - Clinical Trial. Among authors: Mitchell HM. PMID 9083908
Symptomatic patients (n = 101) with Helicobacter pylori infection were enrolled into a double-blind, double-dummy study to assess the efficacy of lansoprazole plus amoxycillin in the treatment of H. pylori infection. ...
Symptomatic patients (n = 101) with Helicobacter pylori infection were enrolled into a double-blind, double-dummy study to assess the effica …
Serological response to specific Helicobacter pylori antigens: antibody against CagA antigen is not predictive of gastric cancer in a developing country
Mitchell HM, et al. Am J Gastroenterol 1996. PMID 8792699
The aim of this study was to examine the seroprevalence of antibody to the CagA antigen; as well as other specific H. pylori antigens in symptomatic and asymptomatic individuals resident in Australia and China. METHODS: The Helico-blot 2.0 Western blot system was used for the detection of antibodies to specific antigens of H. pylori in sera obtained from the following H. pylori-positive groups: 19 Australian blood donors, 96 Australian nonulcer dyspepsia patients, 29 Australian duodenal ulcer patients, 35 asymptomatic Chinese subjects, and 48 Chinese gastric cancer patients. ...
The aim of this study was to examine the seroprevalence of antibody to the CagA antigen; as well as other specific H. pylori antigens …
Association of Helicobacter pylori with gastric cancer and observations on the detection of this bacterium in gastric cancer cases
Hu PJ, et al. Am J Gastroenterol 1994. Among authors: Mitchell HM. PMID 7942672
For the detection of H. pylori, both biopsy specimens and sera were collected from the patients, whereas only sera were collected from the controls. ...CONCLUSIONS: These data provide supporting evidence of an association between H. pylori infection and gastric cancer and indicate that, in certain circumstances, histological evaluation of H. pylori infection in gastric cancer cases may be less reliable than serological evaluation....
For the detection of H. pylori, both biopsy specimens and sera were collected from the patients, whereas only sera were collected fro …
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