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Frailty in relation to the accumulation of deficits.
Rockwood K, Mitnitski A. Rockwood K, et al. Among authors: mitnitski a. J Gerontol A Biol Sci Med Sci. 2007 Jul;62(7):722-7. doi: 10.1093/gerona/62.7.722. J Gerontol A Biol Sci Med Sci. 2007. PMID: 17634318 Review.
Recalling that frailty is an age-associated, nonspecific vulnerability, we consider symptoms, signs, diseases, and disabilities as deficits, which are combined in a frailty index. ...Although based on a simple count, the frailty index shows several interesting prope …
Recalling that frailty is an age-associated, nonspecific vulnerability, we consider symptoms, signs, diseases, and disabilities as deficits, …
The rate of decline in function in Alzheimer's disease and other dementias.
Mitnitski AB, Graham JE, Mogilner AJ, Rockwood K. Mitnitski AB, et al. J Gerontol A Biol Sci Med Sci. 1999 Feb;54(2):M65-9. doi: 10.1093/gerona/54.2.m65. J Gerontol A Biol Sci Med Sci. 1999. PMID: 10051857
BACKGROUND: Functional impairment over time is a necessary condition for the diagnosis of dementia. Increasingly, it is recognized that rates of decline may not follow a linear progression. ...We calculated a measure identified as an impairment index, defined …
BACKGROUND: Functional impairment over time is a necessary condition for the diagnosis of dementia. Increasingly, it is recognized th …
Frailty, fitness and late-life mortality in relation to chronological and biological age.
Mitnitski AB, Graham JE, Mogilner AJ, Rockwood K. Mitnitski AB, et al. BMC Geriatr. 2002 Feb 27;2:1. doi: 10.1186/1471-2318-2-1. BMC Geriatr. 2002. PMID: 11897015 Free PMC article.
METHODS: In a secondary analysis of a representative cohort of Canadians aged 65 and over (n = 2914) we estimated a frailty index based on the proportion of 20 deficits observed in a structured clinical examination. ...RESULTS: The average value of the …
METHODS: In a secondary analysis of a representative cohort of Canadians aged 65 and over (n = 2914) we estimated a fra …
The mortality rate as a function of accumulated deficits in a frailty index.
Mitnitski AB, Mogilner AJ, MacKnight C, Rockwood K. Mitnitski AB, et al. Mech Ageing Dev. 2002 Sep;123(11):1457-60. doi: 10.1016/s0047-6374(02)00082-9. Mech Ageing Dev. 2002. PMID: 12425952
In a representative Canadian population survey (n=66589) the proportion of accumulated deficits in a frailty index showed a linear relationship with mortality in a log-log plot, such that the mortality rate was a power-law function of the frailt …
In a representative Canadian population survey (n=66589) the proportion of accumulated deficits in a frailty index showed a
Techniques for knowledge discovery in existing biomedical databases: estimation of individual aging effects in cognition in relation to dementia.
Mitnitski AB, Mogilner AJ, Graham JE, Rockwood K. Mitnitski AB, et al. J Clin Epidemiol. 2003 Feb;56(2):116-23. doi: 10.1016/s0895-4356(02)00581-4. J Clin Epidemiol. 2003. PMID: 12654405
Accumulation of deficits as a proxy measure of aging.
Mitnitski AB, Mogilner AJ, Rockwood K. Mitnitski AB, et al. ScientificWorldJournal. 2001 Aug 8;1:323-36. doi: 10.1100/tsw.2001.58. ScientificWorldJournal. 2001. PMID: 12806071 Free PMC article.
In a representative database of elderly Canadians we found that deficits accumulated at 3% per year, and show a gamma distribution, typical for systems with redundant components that can be used in case of failure of a given subsystem. ...In consequence, we p …
In a representative database of elderly Canadians we found that deficits accumulated at 3% per year, and show a gamma distribu …
The accumulation of deficits with age and possible invariants of aging.
Mitnitski AB, Mogilner AJ, MacKnight C, Rockwood K. Mitnitski AB, et al. ScientificWorldJournal. 2002 Jun 28;2:1816-22. doi: 10.1100/tsw.2002.861. ScientificWorldJournal. 2002. PMID: 12806172 Free PMC article.
This paper extends a method of apprising health status to a broad range of ages from adolescence to old age. The "frailty index" is based on the accumulation of deficits (symptoms, signs, disease classifications) as analyzed in the National Population Health Survey, …
This paper extends a method of apprising health status to a broad range of ages from adolescence to old age. The "frailty inde …
Help available--phenomenological models for research on aging.
Mitnitski A, Rockwood K. Mitnitski A, et al. Sci Aging Knowledge Environ. 2003 Mar 26;2003(12):VP2. doi: 10.1126/sageke.2003.12.vp2. Sci Aging Knowledge Environ. 2003. PMID: 12844517
Assessment of individual risk of death using self-report data: an artificial neural network compared with a frailty index.
Song X, Mitnitski A, MacKnight C, Rockwood K. Song X, et al. Among authors: mitnitski a. J Am Geriatr Soc. 2004 Jul;52(7):1180-4. doi: 10.1111/j.1532-5415.2004.52319.x. J Am Geriatr Soc. 2004. PMID: 15209659
A separate testing sample was used to evaluate the accuracy of prediction. PARTICIPANTS: A total of 8,547 Canadians aged 65 to 99, of whom 1,865 died during 72 months of follow-up. ...
A separate testing sample was used to evaluate the accuracy of prediction. PARTICIPANTS: A total of 8,547 Canadians aged 65 to
The estimation of relative fitness and frailty in community-dwelling older adults using self-report data.
Mitnitski AB, Song X, Rockwood K. Mitnitski AB, et al. J Gerontol A Biol Sci Med Sci. 2004 Jun;59(6):M627-32. doi: 10.1093/gerona/59.6.m627. J Gerontol A Biol Sci Med Sci. 2004. PMID: 15215283
We developed one measure of health status, personal biological age, from a frailty index. The index itself is a count of deficits derived, in the first instance, from a clinical database. ...CONCLUSIONS: A frailty index, based on self-report data, can …
We developed one measure of health status, personal biological age, from a frailty index. The index itself is a count of defic …
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