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Assessing biological aging: the origin of deficit accumulation.
Mitnitski A, Song X, Rockwood K. Mitnitski A, et al. Biogerontology. 2013 Dec;14(6):709-17. doi: 10.1007/s10522-013-9446-3. Epub 2013 Jul 17. Biogerontology. 2013. PMID: 23860844 Free PMC article.
This allows health to be expressed in a single number: the frailty index (FI) is the ratio of the deficits present in a person to the total number of deficits considered (e.g. in a given database or experimental procedure). ...Here, we apply a stochast …
This allows health to be expressed in a single number: the frailty index (FI) is the ratio of the deficits present in a person …
Vector diagnostics in dementia derived from Bayes' theorem.
Mitnitski AB, Graham JE, Mogilner AJ, Rockwood K. Mitnitski AB, et al. Am J Epidemiol. 1997 Oct 15;146(8):665-71. doi: 10.1093/oxfordjournals.aje.a009333. Am J Epidemiol. 1997. PMID: 9345121
Based on a Bayesian approach, the probability distribution for the etiologically heterogeneous dementia diagnoses is estimated from the Canadian Study of Health and Aging database. ...This method facilitates the establishment of a probability for more than one diagn …
Based on a Bayesian approach, the probability distribution for the etiologically heterogeneous dementia diagnoses is estimated from t …
Dynamics of cognitive aging: distinguishing functional age and disease from chronologic age in a population.
Graham JE, Mitnitski AB, Mogilner AJ, Rockwood K. Graham JE, et al. Among authors: mitnitski ab. Am J Epidemiol. 1999 Nov 15;150(10):1045-54. doi: 10.1093/oxfordjournals.aje.a009928. Am J Epidemiol. 1999. PMID: 10568619
Using secondary analysis of a national representative database (Canadian Study of Health and Aging, 1991-1992), the authors show that the occurrence of an adverse event (symptom, sign, or disease), or the accumulation of a number of events, may be modeled as a
Using secondary analysis of a national representative database (Canadian Study of Health and Aging, 1991-1992), the authors show that …
The mortality rate as a function of accumulated deficits in a frailty index.
Mitnitski AB, Mogilner AJ, MacKnight C, Rockwood K. Mitnitski AB, et al. Mech Ageing Dev. 2002 Sep;123(11):1457-60. doi: 10.1016/s0047-6374(02)00082-9. Mech Ageing Dev. 2002. PMID: 12425952
In a representative Canadian population survey (n=66589) the proportion of accumulated deficits in a frailty index showed a linear relationship with mortality in a log-log plot, such that the mortality rate was a power-law function of the frailt …
In a representative Canadian population survey (n=66589) the proportion of accumulated deficits in a frailty index showed a
Techniques for knowledge discovery in existing biomedical databases: estimation of individual aging effects in cognition in relation to dementia.
Mitnitski AB, Mogilner AJ, Graham JE, Rockwood K. Mitnitski AB, et al. J Clin Epidemiol. 2003 Feb;56(2):116-23. doi: 10.1016/s0895-4356(02)00581-4. J Clin Epidemiol. 2003. PMID: 12654405
Accumulation of deficits as a proxy measure of aging.
Mitnitski AB, Mogilner AJ, Rockwood K. Mitnitski AB, et al. ScientificWorldJournal. 2001 Aug 8;1:323-36. doi: 10.1100/tsw.2001.58. ScientificWorldJournal. 2001. PMID: 12806071 Free PMC article.
In a representative database of elderly Canadians we found that deficits accumulated at 3% per year, and show a gamma distribution, typical for systems with redundant components that can be used in case of failure of a given subsystem. ...In consequence, we p …
In a representative database of elderly Canadians we found that deficits accumulated at 3% per year, and show a gamma distribu …
The accumulation of deficits with age and possible invariants of aging.
Mitnitski AB, Mogilner AJ, MacKnight C, Rockwood K. Mitnitski AB, et al. ScientificWorldJournal. 2002 Jun 28;2:1816-22. doi: 10.1100/tsw.2002.861. ScientificWorldJournal. 2002. PMID: 12806172 Free PMC article.
This paper extends a method of apprising health status to a broad range of ages from adolescence to old age. The "frailty index" is based on the accumulation of deficits (symptoms, signs, disease classifications) as analyzed in the National Population Health Survey, …
This paper extends a method of apprising health status to a broad range of ages from adolescence to old age. The "frailty inde …
Help available--phenomenological models for research on aging.
Mitnitski A, Rockwood K. Mitnitski A, et al. Sci Aging Knowledge Environ. 2003 Mar 26;2003(12):VP2. doi: 10.1126/sageke.2003.12.vp2. Sci Aging Knowledge Environ. 2003. PMID: 12844517
Assessment of individual risk of death using self-report data: an artificial neural network compared with a frailty index.
Song X, Mitnitski A, MacKnight C, Rockwood K. Song X, et al. Among authors: mitnitski a. J Am Geriatr Soc. 2004 Jul;52(7):1180-4. doi: 10.1111/j.1532-5415.2004.52319.x. J Am Geriatr Soc. 2004. PMID: 15209659
A separate testing sample was used to evaluate the accuracy of prediction. PARTICIPANTS: A total of 8,547 Canadians aged 65 to 99, of whom 1,865 died during 72 months of follow-up. ...
A separate testing sample was used to evaluate the accuracy of prediction. PARTICIPANTS: A total of 8,547 Canadians aged 65 to
The estimation of relative fitness and frailty in community-dwelling older adults using self-report data.
Mitnitski AB, Song X, Rockwood K. Mitnitski AB, et al. J Gerontol A Biol Sci Med Sci. 2004 Jun;59(6):M627-32. doi: 10.1093/gerona/59.6.m627. J Gerontol A Biol Sci Med Sci. 2004. PMID: 15215283
We developed one measure of health status, personal biological age, from a frailty index. The index itself is a count of deficits derived, in the first instance, from a clinical database. ...CONCLUSIONS: A frailty index, based on self-report data, can …
We developed one measure of health status, personal biological age, from a frailty index. The index itself is a count of defic …
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