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Did you mean mito (4,325 results)?
Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults.
Rossman MJ, Santos-Parker JR, Steward CAC, Bispham NZ, Cuevas LM, Rosenberg HL, Woodward KA, Chonchol M, Gioscia-Ryan RA, Murphy MP, Seals DR. Rossman MJ, et al. Hypertension. 2018 Jun;71(6):1056-1063. doi: 10.1161/HYPERTENSIONAHA.117.10787. Epub 2018 Apr 16. Hypertension. 2018. PMID: 29661838 Free PMC article. Clinical Trial.
MitoQ was well tolerated, and plasma MitoQ was higher after the treatment versus placebo period (P<0.05). Brachial artery flow-mediated dilation was 42% higher after MitoQ versus placebo (P<0.05); the improvement was associated with amelioration of mito …
MitoQ was well tolerated, and plasma MitoQ was higher after the treatment versus placebo period (P<0.05). Brachial artery f …
The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1.
Xiao L, Xu X, Zhang F, Wang M, Xu Y, Tang D, Wang J, Qin Y, Liu Y, Tang C, He L, Greka A, Zhou Z, Liu F, Dong Z, Sun L. Xiao L, et al. Redox Biol. 2017 Apr;11:297-311. doi: 10.1016/j.redox.2016.12.022. Epub 2016 Dec 21. Redox Biol. 2017. PMID: 28033563 Free PMC article.
MitoQ is a mitochondria-targeted antioxidant that exerts protective effects in diabetic mice, but the mechanism underlying these effects is not clear. ...These changes were partially reversed following an intraperitoneal injection of mitoQ. High glucose (HG) also in …
MitoQ is a mitochondria-targeted antioxidant that exerts protective effects in diabetic mice, but the mechanism underlying these effe …
MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload.
Ribeiro Junior RF, Dabkowski ER, Shekar KC, O Connell KA, Hecker PA, Murphy MP. Ribeiro Junior RF, et al. Free Radic Biol Med. 2018 Mar;117:18-29. doi: 10.1016/j.freeradbiomed.2018.01.012. Epub 2018 Feb 2. Free Radic Biol Med. 2018. PMID: 29421236 Free PMC article.
However, we observed a reduction in right ventricular hypertrophy and lung congestion in heart failure animals treated with MitoQ. ...Moreover, MitoQ restored mitochondrial respiration in heart failure induced by pressure overload. We also detected higher levels of …
However, we observed a reduction in right ventricular hypertrophy and lung congestion in heart failure animals treated with MitoQ. .. …
The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway.
Hu Q, Ren J, Li G, Wu J, Wu X, Wang G, Gu G, Ren H, Hong Z, Li J. Hu Q, et al. Cell Death Dis. 2018 Mar 14;9(3):403. doi: 10.1038/s41419-018-0436-x. Cell Death Dis. 2018. PMID: 29540694 Free PMC article.
MitoQ is a mitochondrially targeted antioxidant that exerts protective effects following I/R injury. In the present study, we aimed to determine whether and how MitoQ protects intestinal epithelial cells (IECs) from I/R injury. ...In conclusion, our data suggest tha …
MitoQ is a mitochondrially targeted antioxidant that exerts protective effects following I/R injury. In the present study, we aimed t …
Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease.
Hao L, Sun Q, Zhong W, Zhang W, Sun X, Zhou Z. Hao L, et al. Redox Biol. 2018 Apr;14:626-636. doi: 10.1016/j.redox.2017.11.005. Epub 2017 Nov 11. Redox Biol. 2018. PMID: 29156373 Free PMC article.
Male C57BL/6J mice were exposed to alcohol for 8 weeks with MitoQ supplementation (5mg/kg/d) for the last 4 weeks. MitoQ ameliorated alcohol-induced oxidative/nitrosative stress and glutathione deficiency. ...MitoQ also reversed alcohol-induced hepatic lipid …
Male C57BL/6J mice were exposed to alcohol for 8 weeks with MitoQ supplementation (5mg/kg/d) for the last 4 weeks. MitoQ ameli …
MitoQ ameliorates testis injury from oxidative attack by repairing mitochondria and promoting the Keap1-Nrf2 pathway.
Zhang J, Bao X, Zhang M, Zhu Z, Zhou L, Chen Q, Zhang Q, Ma B. Zhang J, et al. Toxicol Appl Pharmacol. 2019 May 1;370:78-92. doi: 10.1016/j.taap.2019.03.001. Epub 2019 Mar 2. Toxicol Appl Pharmacol. 2019. PMID: 30836114
On this basis, the results from pharmacokinetic study indicated that the MitoQ could enter into testis tissues after oral administration in despite of the low absolute bioavailability, which provided the material basis for MitoQ in the treatment of testicular damage …
On this basis, the results from pharmacokinetic study indicated that the MitoQ could enter into testis tissues after oral administrat …
The Effect of MitoQ on Aging-Related Biomarkers: A Systematic Review and Meta-Analysis.
Braakhuis AJ, Nagulan R, Somerville V. Braakhuis AJ, et al. Oxid Med Cell Longev. 2018 Jul 12;2018:8575263. doi: 10.1155/2018/8575263. eCollection 2018. Oxid Med Cell Longev. 2018. PMID: 30116495 Free PMC article. Review.
MitoQ is a mitochondria-targeted antioxidant of which is reported to support healthy aging. The aim of this systematic review is to investigate the effects of MitoQ on oxidative outcomes related to the aging process. ...MitoQ may be of some benefit in allevia …
MitoQ is a mitochondria-targeted antioxidant of which is reported to support healthy aging. The aim of this systematic review is to i …
Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension.
Pak O, Scheibe S, Esfandiary A, Gierhardt M, Sydykov A, Logan A, Fysikopoulos A, Veit F, Hecker M, Kroschel F, Quanz K, Erb A, Schäfer K, Fassbinder M, Alebrahimdehkordi N, Ghofrani HA, Schermuly RT, Brandes RP, Seeger W, Murphy MP, Weissmann N, Sommer N. Pak O, et al. Eur Respir J. 2018 Feb 1:1701024. doi: 10.1183/13993003.01024-2017. Online ahead of print. Eur Respir J. 2018. PMID: 29419444
MitoQ significantly inhibited HPV and acute hypoxia-induced rise in superoxide concentration. ROS was decreased in PASMC, while it increased in the RV after chronic hypoxia. ...MitoQ may be beneficial under conditions of exaggerated acute HPV....
MitoQ significantly inhibited HPV and acute hypoxia-induced rise in superoxide concentration. ROS was decreased in PASMC, while it in …
The Antioxidant MitoQ Protects Against CSE-Induced Endothelial Barrier Injury and Inflammation by Inhibiting ROS and Autophagy in Human Umbilical Vein Endothelial Cells.
Chen S, Wang Y, Zhang H, Chen R, Lv F, Li Z, Jiang T, Lin D, Zhang H, Yang L, Kong X. Chen S, et al. Int J Biol Sci. 2019 Jun 2;15(7):1440-1451. doi: 10.7150/ijbs.30193. eCollection 2019. Int J Biol Sci. 2019. PMID: 31337974 Free PMC article.
In addition, MitoQ also maintained mitochondrial function by reducing the production of ROS and excess autophagy. Inhibition of autophagy by 3-MA protected against cytotoxicity that was induced by CSE in HUVECs. ...The protective effect of MitoQ is related to the in …
In addition, MitoQ also maintained mitochondrial function by reducing the production of ROS and excess autophagy. Inhibition of autop …
The Mitochondria-Targeted Antioxidant MitoQ Modulates Mitochondrial Function and Endoplasmic Reticulum Stress in Pancreatic β Cells Exposed to Hyperglycaemia.
Escribano-Lopez I, Bañuls C, Diaz-Morales N, Iannantuoni F, Rovira-Llopis S, Gomis R, Rocha M, Hernandez-Mijares A, Murphy MP, Victor VM. Escribano-Lopez I, et al. Cell Physiol Biochem. 2019;52(2):186-197. doi: 10.33594/000000013. Epub 2019 Feb 28. Cell Physiol Biochem. 2019. PMID: 30816667 Free article.
BACKGROUND/AIMS: Mitochondria-targeted antioxidants such as mitoquinone (MitoQ) have demonstrated protective effects against oxidative damage in several diseases. ...MitoQ did not significantly alter ER stress markers under lipidic conditions. CONCLUSION: Our findin …
BACKGROUND/AIMS: Mitochondria-targeted antioxidants such as mitoquinone (MitoQ) have demonstrated protective effects against oxidativ …
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