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Did you mean mito (5,361 results)?
The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1.
Xiao L, Xu X, Zhang F, Wang M, Xu Y, Tang D, Wang J, Qin Y, Liu Y, Tang C, He L, Greka A, Zhou Z, Liu F, Dong Z, Sun L. Xiao L, et al. Redox Biol. 2017 Apr;11:297-311. doi: 10.1016/j.redox.2016.12.022. Epub 2016 Dec 21. Redox Biol. 2017. PMID: 28033563 Free PMC article.
These changes were partially reversed following an intraperitoneal injection of mitoQ. High glucose (HG) also induces deficient mitophagy, mitochondrial dysfunction and apoptosis in HK-2 cells, changes that were reversed by mitoQ. ...Transfection with Nrf2 siRNA or …
These changes were partially reversed following an intraperitoneal injection of mitoQ. High glucose (HG) also induces deficient mitop …
MitoQ alleviates LPS-mediated acute lung injury through regulating Nrf2/Drp1 pathway.
Hou L, Zhang J, Liu Y, Fang H, Liao L, Wang Z, Yuan J, Wang X, Sun J, Tang B, Chen H, Ye P, Ding Z, Lu H, Wang Y, Wang X. Hou L, et al. Free Radic Biol Med. 2021 Mar;165:219-228. doi: 10.1016/j.freeradbiomed.2021.01.045. Epub 2021 Feb 1. Free Radic Biol Med. 2021. PMID: 33539948
Lipopolysaccharide (LPS) has been known to cause alveolar epithelial cell (AEC) apoptosis and barrier breakdown that characterize acute lung injury (ALI) and acute respiratory distress syndrome. We aimed to investigate whether mitoquinone (MitoQ), a mitochondria-tar …
Lipopolysaccharide (LPS) has been known to cause alveolar epithelial cell (AEC) apoptosis and barrier breakdown that characterize acute lung …
MitoQ protects against hyperpermeability of endothelium barrier in acute lung injury via a Nrf2-dependent mechanism.
Cen M, Ouyang W, Zhang W, Yang L, Lin X, Dai M, Hu H, Tang H, Liu H, Xia J, Xu F. Cen M, et al. Redox Biol. 2021 May;41:101936. doi: 10.1016/j.redox.2021.101936. Epub 2021 Mar 6. Redox Biol. 2021. PMID: 33752110 Free PMC article.
We demonstrated that overoxidation occurred during the process of ALI, which could be reduced by mitoQ. In the meantime, apoptosis of endothelial cells of ALI mice, accompanied by hyperpermeability of pulmonary vascular and impaired pulmonary function, was partially revers …
We demonstrated that overoxidation occurred during the process of ALI, which could be reduced by mitoQ. In the meantime, apoptosis of …
Mitochondria-targeted therapeutics, MitoQ and BGP-15, reverse aging-associated meiotic spindle defects in mouse and human oocytes.
Al-Zubaidi U, Adhikari D, Cinar O, Zhang QH, Yuen WS, Murphy MP, Rombauts L, Robker RL, Carroll J. Al-Zubaidi U, et al. Hum Reprod. 2021 Feb 18;36(3):771-784. doi: 10.1093/humrep/deaa300. Hum Reprod. 2021. PMID: 33367783 Free PMC article.
STUDY DESIGN, SIZE, DURATION: Oocytes from young and old mice were treated with MitoQ and/or BGP-15 during IVM. To directly induce mitochondrial dysfunction, oocytes were treated with H2O2, and then treated the MitoQ and/or BGP-15. ...PARTICIPANTS/MATERIALS, SETTING …
STUDY DESIGN, SIZE, DURATION: Oocytes from young and old mice were treated with MitoQ and/or BGP-15 during IVM. To directly induce mi …
Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults.
Rossman MJ, Santos-Parker JR, Steward CAC, Bispham NZ, Cuevas LM, Rosenberg HL, Woodward KA, Chonchol M, Gioscia-Ryan RA, Murphy MP, Seals DR. Rossman MJ, et al. Hypertension. 2018 Jun;71(6):1056-1063. doi: 10.1161/HYPERTENSIONAHA.117.10787. Epub 2018 Apr 16. Hypertension. 2018. PMID: 29661838 Free PMC article. Clinical Trial.
MitoQ was well tolerated, and plasma MitoQ was higher after the treatment versus placebo period (P<0.05). Brachial artery flow-mediated dilation was 42% higher after MitoQ versus placebo (P<0.05); the improvement was associated with amelioration of mito …
MitoQ was well tolerated, and plasma MitoQ was higher after the treatment versus placebo period (P<0.05). Brachial artery f …
Mitoquinone mesylate (MitoQ) prevents sepsis-induced diaphragm dysfunction.
Supinski GS, Schroder EA, Wang L, Morris AJ, Callahan LAP. Supinski GS, et al. J Appl Physiol (1985). 2021 Aug 1;131(2):778-787. doi: 10.1152/japplphysiol.01053.2020. Epub 2021 Jul 1. J Appl Physiol (1985). 2021. PMID: 34197233 Free PMC article.

CLP decreased diaphragm specific force generation and MitoQ prevented these decrements (e.g. maximal force averaged 30.2 1.3, 28.0 1.3, 12.8 1.9, and 30.0 1.0 N/cm(2) for sham, sham + MitoQ, CLP, and CLP + MitoQ groups, respectively, P < 0.001). ...Mito

…
CLP decreased diaphragm specific force generation and MitoQ prevented these decrements (e.g. maximal force averaged 30.2 1.3, 28.0 1. …
The mitochondria-targeted antioxidant MitoQ attenuated PM2.5-induced vascular fibrosis via regulating mitophagy.
Ning R, Li Y, Du Z, Li T, Sun Q, Lin L, Xu Q, Duan J, Sun Z. Ning R, et al. Redox Biol. 2021 Oct;46:102113. doi: 10.1016/j.redox.2021.102113. Epub 2021 Aug 18. Redox Biol. 2021. PMID: 34425389 Free PMC article.
At present, there is limited data on whether MitoQ can alleviate the vascular damage caused by PM(2.5). Therefore, the current study was aimed to evaluate the protective role of MitoQ on aortic fibrosis induced by PM(2.5) exposure. ...Moreover, the enhanced expressi …
At present, there is limited data on whether MitoQ can alleviate the vascular damage caused by PM(2.5). Therefore, the current study …
MitoQ Is Able to Modulate Apoptosis and Inflammation.
Piscianz E, Tesser A, Rimondi E, Melloni E, Celeghini C, Marcuzzi A. Piscianz E, et al. Int J Mol Sci. 2021 Apr 30;22(9):4753. doi: 10.3390/ijms22094753. Int J Mol Sci. 2021. PMID: 33946176 Free PMC article.
Mitoquinone (MitoQ) is a mitochondrial reactive oxygen species scavenger that is characterized by high bioavailability. ...To verify the role played by MitoQ, we examined the expression of genes involved in the inflammation mechanism and the mitochondrial act …
Mitoquinone (MitoQ) is a mitochondrial reactive oxygen species scavenger that is characterized by high bioavailability. ...To …
MitoQ--a mitochondria-targeted antioxidant.
Tauskela JS. Tauskela JS. IDrugs. 2007 Jun;10(6):399-412. IDrugs. 2007. PMID: 17642004 Review.
MitoQ is an orally active antioxidant that has the ability to target mitochondrial dysfunction. ...Results from the clinical trials with MitoQ will have important repercussions on the relevance of a mitochondrial-targeted approach....
MitoQ is an orally active antioxidant that has the ability to target mitochondrial dysfunction. ...Results from the clinical trials w …
The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance.
Kang L, Liu S, Li J, Tian Y, Xue Y, Liu X. Kang L, et al. Cell Prolif. 2020 Mar;53(3):e12779. doi: 10.1111/cpr.12779. Epub 2020 Feb 5. Cell Prolif. 2020. PMID: 32020711 Free PMC article.
These caused the damaged mitochondria accumulation and persistent oxidative damage. Moreover, MitoQ restored the mitochondrial dynamics balance, alleviated the impairment of mitophagosome-lysosome fusion and lysosomal function and enhanced the Nrf2 activity. Consequently, …
These caused the damaged mitochondria accumulation and persistent oxidative damage. Moreover, MitoQ restored the mitochondrial dynami …
506 results