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Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome.
Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. Salminen A, et al. Prog Neurobiol. 2013 Jul-Aug;106-107:33-54. doi: 10.1016/j.pneurobio.2013.06.002. Epub 2013 Jul 1. Prog Neurobiol. 2013. PMID: 23827971 Review.
Recent studies have indicated that the expression Beclin 1 is reduced in AD brain. Moreover, the deficiency of Beclin 1 in cultured neurons and transgenic mice provokes the deposition of amyloid-beta peptides whereas its overexpression reduces the accumulatio …
Recent studies have indicated that the expression Beclin 1 is reduced in AD brain. Moreover, the deficiency of Beclin 1
Familial glucocorticoid deficiency: New genes and mechanisms.
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJ, Metherell LA. Meimaridou E, et al. Mol Cell Endocrinol. 2013 May 22;371(1-2):195-200. doi: 10.1016/j.mce.2012.12.010. Epub 2012 Dec 29. Mol Cell Endocrinol. 2013. PMID: 23279877 Review.
Familial Glucocorticoid deficiency (FGD), in which the adrenal cortex fails to produce glucocorticoids, was first shown to be caused by defects in the receptor for ACTH (MC2R) or its accessory protein (MRAP). Certain mutations in the steroidogenic acute regulatory protein …
Familial Glucocorticoid deficiency (FGD), in which the adrenal cortex fails to produce glucocorticoids, was first shown to be caused …
Mitochondrial Ca2+ homeostasis in human NADH:ubiquinone oxidoreductase deficiency.
Willems PH, Valsecchi F, Distelmaier F, Verkaart S, Visch HJ, Smeitink JA, Koopman WJ. Willems PH, et al. Cell Calcium. 2008 Jul;44(1):123-33. doi: 10.1016/j.ceca.2008.01.002. Epub 2008 Mar 4. Cell Calcium. 2008. PMID: 18295330 Review.
From the results obtained, the picture emerges that a reduction in cellular complex I activity leads to a depolarization of the mitochondrial membrane potential, resulting in a decreased supply of mitochondrial ATP to the Ca(2+)-ATPases of the intracel …
From the results obtained, the picture emerges that a reduction in cellular complex I activity leads to a depolarization of the mi
Genetics of type 2 diabetes mellitus.
Malecki MT. Malecki MT. Diabetes Res Clin Pract. 2005 Jun;68 Suppl1:S10-21. doi: 10.1016/j.diabres.2005.03.003. Epub 2005 Mar 19. Diabetes Res Clin Pract. 2005. PMID: 15955369 Review.
The clinical picture of type 2 diabetes mellitus (T2DM) is formed by impairment in insulin secretion and resistance to insulin action. ...The majority of proteins associated with MODY are transcription factors, such as hepatocyte nuclear factor 4alpha (HNF-4a …
The clinical picture of type 2 diabetes mellitus (T2DM) is formed by impairment in insulin secretion and resistance to insulin …
Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes.
Legrand-Poels S, Esser N, L'homme L, Scheen A, Paquot N, Piette J. Legrand-Poels S, et al. Biochem Pharmacol. 2014 Nov 1;92(1):131-41. doi: 10.1016/j.bcp.2014.08.013. Epub 2014 Aug 28. Biochem Pharmacol. 2014. PMID: 25175736 Review.
We focus on emerging models of NLRP3 inflammasome activation with a special emphasis on the molecular mechanisms by which FFAs modulate the activation of this complex. Taking into consideration the current literature and FFA properties, we discuss the putative involvement …
We focus on emerging models of NLRP3 inflammasome activation with a special emphasis on the molecular mechanisms by which FFAs modulate the …
Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in type II diabetes.
Wollheim CB. Wollheim CB. Diabetologia. 2000 Mar;43(3):265-77. doi: 10.1007/s001250050044. Diabetologia. 2000. PMID: 10768087 Review.
The resulting generation of glutamate participates in Ca(2+)-stimulated exocytosis. Mitochondrial DNA (mtDNA) encodes some of the polypeptides of the respiratory chain enzyme complexes. ...A cellular model of MODY3 expressing dominant-negative hepatocyte n
The resulting generation of glutamate participates in Ca(2+)-stimulated exocytosis. Mitochondrial DNA (mtDNA) encodes some of …