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Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome.
Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. Salminen A, et al. Prog Neurobiol. 2013 Jul-Aug;106-107:33-54. doi: 10.1016/j.pneurobio.2013.06.002. Epub 2013 Jul 1. Prog Neurobiol. 2013. PMID: 23827971 Review.
Recent studies have indicated that the expression Beclin 1 is reduced in AD brain. Moreover, the deficiency of Beclin 1 in cultured neurons and transgenic mice provokes the deposition of amyloid-beta peptides whereas its overexpression reduces the accumulatio …
Recent studies have indicated that the expression Beclin 1 is reduced in AD brain. Moreover, the deficiency of Beclin 1 …
Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes.
Legrand-Poels S, Esser N, L'homme L, Scheen A, Paquot N, Piette J. Legrand-Poels S, et al. Biochem Pharmacol. 2014 Nov 1;92(1):131-41. doi: 10.1016/j.bcp.2014.08.013. Epub 2014 Aug 28. Biochem Pharmacol. 2014. PMID: 25175736 Review.
We focus on emerging models of NLRP3 inflammasome activation with a special emphasis on the molecular mechanisms by which FFAs modulate the activation of this complex. Taking into consideration the current literature and FFA properties, we discuss the putative involvement …
We focus on emerging models of NLRP3 inflammasome activation with a special emphasis on the molecular mechanisms by which FFAs modulate the …
Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in type II diabetes.
Wollheim CB. Wollheim CB. Diabetologia. 2000 Mar;43(3):265-77. doi: 10.1007/s001250050044. Diabetologia. 2000. PMID: 10768087 Review.
The resulting generation of glutamate participates in Ca(2+)-stimulated exocytosis. Mitochondrial DNA (mtDNA) encodes some of the polypeptides of the respiratory chain enzyme complexes. ...A cellular model of MODY3 expressing dominant-negative hepatocyte nuclear …
The resulting generation of glutamate participates in Ca(2+)-stimulated exocytosis. Mitochondrial DNA (mtDNA) encodes some of the pol …