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Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome.
Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. Salminen A, et al. Prog Neurobiol. 2013 Jul-Aug;106-107:33-54. doi: 10.1016/j.pneurobio.2013.06.002. Epub 2013 Jul 1. Prog Neurobiol. 2013. PMID: 23827971 Review.
Recent studies have indicated that the expression Beclin 1 is reduced in AD brain. Moreover, the deficiency of Beclin 1 in cultured neurons and transgenic mice provokes the deposition of amyloid-beta peptides whereas its overexpression reduces the accumulatio …
Recent studies have indicated that the expression Beclin 1 is reduced in AD brain. Moreover, the deficiency of Beclin 1
Nuclear gene defects in mitochondrial disorders.
Zeviani M, Corona P, Nijtmans L, Tiranti V. Zeviani M, et al. Ital J Neurol Sci. 1999 Dec;20(6):401-8. doi: 10.1007/s100720050059. Ital J Neurol Sci. 1999. PMID: 10937860 Review.
An increasing number of nuclear genes have been associated with abnormalities of oxidative phosphorylation and mitochondrial disorders. ...Loss-of-function mutations in SURF-1, a gene belonging to the third category, have been associated with Leigh syndrome w …
An increasing number of nuclear genes have been associated with abnormalities of oxidative phosphorylation and mitochondrial d …