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2001 1
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2011 3
2012 6
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2014 7
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2016 8
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Page 1
Discovery and characterization of a new class of NAD+-independent SIRT1 activators.
Della Torre S, Dell'Omo G, Dellavedova J, Palazzolo L, Scanziani E, Eberini I, Pinto A, Mitro N, Conti P, Villa A, Ciana P. Della Torre S, et al. Among authors: mitro n. Pharmacol Res. 2024 Aug;206:107296. doi: 10.1016/j.phrs.2024.107296. Epub 2024 Jul 4. Pharmacol Res. 2024. PMID: 38971269 Free article.
Frataxin deficiency shifts metabolism to promote reactive microglia via glucose catabolism.
Sciarretta F, Zaccaria F, Ninni A, Ceci V, Turchi R, Apolloni S, Milani M, Della Valle I, Tiberi M, Chiurchiù V, D'Ambrosi N, Pedretti S, Mitro N, Volontè C, Amadio S, Aquilano K, Lettieri-Barbato D. Sciarretta F, et al. Among authors: mitro n. Life Sci Alliance. 2024 Apr 17;7(7):e202402609. doi: 10.26508/lsa.202402609. Print 2024 Jul. Life Sci Alliance. 2024. PMID: 38631900 Free PMC article.
Activation of endogenous retroviruses and induction of viral mimicry by MEK1/2 inhibition in pancreatic cancer.
Cortesi A, Gandolfi F, Arco F, Di Chiaro P, Valli E, Polletti S, Noberini R, Gualdrini F, Attanasio S, Citron F, Ho IL, Shah R, Yen EY, Spinella MC, Ronzoni S, Rodighiero S, Mitro N, Bonaldi T, Ghisletti S, Monticelli S, Viale A, Diaferia GR, Natoli G. Cortesi A, et al. Among authors: mitro n. Sci Adv. 2024 Mar 29;10(13):eadk5386. doi: 10.1126/sciadv.adk5386. Epub 2024 Mar 27. Sci Adv. 2024. PMID: 38536927 Free PMC article.
Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide.
Russo M, Gualdrini F, Vallelonga V, Prosperini E, Noberini R, Pedretti S, Borriero C, Di Chiaro P, Polletti S, Imperato G, Marenda M, Ghirardi C, Bedin F, Cuomo A, Rodighiero S, Bonaldi T, Mitro N, Ghisletti S, Natoli G. Russo M, et al. Among authors: mitro n. Mol Cell. 2024 Mar 7;84(5):967-980.e10. doi: 10.1016/j.molcel.2023.12.033. Epub 2024 Jan 18. Mol Cell. 2024. PMID: 38242130
Prostaglandin D2 synthase controls Schwann cells metabolism.
Trimarco A, Audano M, Marca R, Cariello M, Falco M, Pedretti S, Imperato G, Cestaro A, Podini P, Dina G, Quattrini A, Massimino L, Caruso D, Mitro N, Taveggia C. Trimarco A, et al. Among authors: mitro n. bioRxiv [Preprint]. 2024 Mar 4:2024.02.29.582775. doi: 10.1101/2024.02.29.582775. bioRxiv. 2024. PMID: 38496560 Free PMC article. Preprint.
Glucose-derived glutamate drives neuronal terminal differentiation in vitro.
D'Andrea L, Audano M, Pedretti S, Pelucchi S, Stringhi R, Imperato G, De Cesare G, Cambria C, Laporte MH, Zamboni N, Antonucci F, Di Luca M, Mitro N, Marcello E. D'Andrea L, et al. Among authors: mitro n. EMBO Rep. 2024 Mar;25(3):991-1021. doi: 10.1038/s44319-023-00048-8. Epub 2024 Jan 19. EMBO Rep. 2024. PMID: 38243137 Free PMC article.
The inhibition of inner mitochondrial fusion in hepatocytes reduces non-alcoholic fatty liver and improves metabolic profile during obesity by modulating bile acid conjugation.
Da Dalt L, Moregola A, Svecla M, Pedretti S, Fantini F, Ronzio M, Uboldi P, Dolfini D, Donetti E, Baragetti A, Mitro N, Scorrano L, Norata GD. Da Dalt L, et al. Among authors: mitro n. Cardiovasc Res. 2024 Feb 17;119(18):2917-2929. doi: 10.1093/cvr/cvad169. Cardiovasc Res. 2024. PMID: 37922889
Editorial: Epigenetics and metabolism.
Mitro N, Verdeguer F, Perissi V. Mitro N, et al. Front Endocrinol (Lausanne). 2024 Feb 9;15:1373368. doi: 10.3389/fendo.2024.1373368. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38405145 Free PMC article. No abstract available.
Author Correction: Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth.
Tombari C, Zannini A, Bertolio R, Pedretti S, Audano M, Triboli L, Cancila V, Vacca D, Caputo M, Donzelli S, Segatto I, Vodret S, Piazza S, Rustighi A, Mantovani F, Belletti B, Baldassarre G, Blandino G, Tripodo C, Bicciato S, Mitro N, Del Sal G. Tombari C, et al. Among authors: mitro n. Nat Commun. 2023 Nov 6;14(1):7129. doi: 10.1038/s41467-023-43018-3. Nat Commun. 2023. PMID: 37932286 Free PMC article. No abstract available.
Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth.
Tombari C, Zannini A, Bertolio R, Pedretti S, Audano M, Triboli L, Cancila V, Vacca D, Caputo M, Donzelli S, Segatto I, Vodret S, Piazza S, Rustighi A, Mantovani F, Belletti B, Baldassarre G, Blandino G, Tripodo C, Bicciato S, Mitro N, Del Sal G. Tombari C, et al. Among authors: mitro n. Nat Commun. 2023 Oct 25;14(1):6777. doi: 10.1038/s41467-023-42458-1. Nat Commun. 2023. PMID: 37880212 Free PMC article.
Butyrate prevents visceral adipose tissue inflammation and metabolic alterations in a Friedreich's ataxia mouse model.
Turchi R, Sciarretta F, Ceci V, Tiberi M, Audano M, Pedretti S, Panebianco C, Nesci V, Pazienza V, Ferri A, Carotti S, Chiurchiù V, Mitro N, Lettieri-Barbato D, Aquilano K. Turchi R, et al. Among authors: mitro n. iScience. 2023 Aug 28;26(10):107713. doi: 10.1016/j.isci.2023.107713. eCollection 2023 Oct 20. iScience. 2023. PMID: 37701569 Free PMC article.
Spinocerebellar ataxia 38: structure-function analysis shows ELOVL5 G230V is proteotoxic, conformationally altered and a mutational hotspot.
Ferrero E, Di Gregorio E, Ferrero M, Ortolan E, Moon YA, Di Campli A, Pavinato L, Mancini C, Tripathy D, Manes M, Hoxha E, Costanzi C, Pozzi E, Rossi Sebastiano M, Mitro N, Tempia F, Caruso D, Borroni B, Basso M, Sallese M, Brusco A. Ferrero E, et al. Among authors: mitro n. Hum Genet. 2023 Aug;142(8):1055-1076. doi: 10.1007/s00439-023-02572-y. Epub 2023 May 18. Hum Genet. 2023. PMID: 37199746 Free PMC article.
Liver-directed gene therapy for ornithine aminotransferase deficiency.
Boffa I, Polishchuk E, De Stefano L, Dell'Aquila F, Nusco E, Marrocco E, Audano M, Pedretti S, Caterino M, Bellezza I, Ruoppolo M, Mitro N, Cellini B, Auricchio A, Brunetti-Pierri N. Boffa I, et al. Among authors: mitro n. EMBO Mol Med. 2023 Apr 11;15(4):e17033. doi: 10.15252/emmm.202217033. Epub 2023 Jan 17. EMBO Mol Med. 2023. PMID: 36647689 Free PMC article.
Bicalutamide and Trehalose Ameliorate Spinal and Bulbar Muscular Atrophy Pathology in Mice.
Galbiati M, Meroni M, Boido M, Cescon M, Rusmini P, Crippa V, Cristofani R, Piccolella M, Ferrari V, Tedesco B, Casarotto E, Chierichetti M, Cozzi M, Mina F, Cicardi ME, Pedretti S, Mitro N, Caretto A, Risè P, Sala A, Lieberman AP, Bonaldo P, Pennuto M, Vercelli A, Poletti A. Galbiati M, et al. Among authors: mitro n. Neurotherapeutics. 2023 Mar;20(2):524-545. doi: 10.1007/s13311-023-01343-x. Epub 2023 Jan 30. Neurotherapeutics. 2023. PMID: 36717478 Free PMC article.
Loss of voltage-gated hydrogen channel 1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T cells.
Coe D, Poobalasingam T, Fu H, Bonacina F, Wang G, Morales V, Moregola A, Mitro N, Cheung KC, Ward EJ, Nadkarni S, Aksentijevic D, Bianchi K, Norata GD, Capasso M, Marelli-Berg FM. Coe D, et al. Among authors: mitro n. JCI Insight. 2022 May 23;7(10):e147814. doi: 10.1172/jci.insight.147814. JCI Insight. 2022. PMID: 35472029 Free PMC article.
Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue.
Rosina M, Ceci V, Turchi R, Chuan L, Borcherding N, Sciarretta F, Sánchez-Díaz M, Tortolici F, Karlinsey K, Chiurchiù V, Fuoco C, Giwa R, Field RL, Audano M, Arena S, Palma A, Riccio F, Shamsi F, Renzone G, Verri M, Crescenzi A, Rizza S, Faienza F, Filomeni G, Kooijman S, Rufini S, de Vries AAF, Scaloni A, Mitro N, Tseng YH, Hidalgo A, Zhou B, Brestoff JR, Aquilano K, Lettieri-Barbato D. Rosina M, et al. Among authors: mitro n. Cell Metab. 2022 Apr 5;34(4):533-548.e12. doi: 10.1016/j.cmet.2022.02.016. Epub 2022 Mar 18. Cell Metab. 2022. PMID: 35305295 Free PMC article.
Author Correction: The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites.
Bean C, Audano M, Varanita T, Favaretto F, Medaglia M, Gerdol M, Pernas L, Stasi F, Giacomello M, Herkenne S, Muniandy M, Heinonen S, Cazaly E, Ollikainen M, Milan G, Pallavicini A, Pietiläinen KH, Vettor R, Mitro N, Scorrano L. Bean C, et al. Among authors: mitro n. Nat Metab. 2022 Feb;4(2):300. doi: 10.1038/s42255-022-00548-2. Nat Metab. 2022. PMID: 35149842 No abstract available.
The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites.
Bean C, Audano M, Varanita T, Favaretto F, Medaglia M, Gerdol M, Pernas L, Stasi F, Giacomello M, Herkenne S, Muniandy M, Heinonen S, Cazaly E, Ollikainen M, Milan G, Pallavicini A, Pietiläinen KH, Vettor R, Mitro N, Scorrano L. Bean C, et al. Among authors: mitro n. Nat Metab. 2021 Dec;3(12):1633-1647. doi: 10.1038/s42255-021-00497-2. Epub 2021 Dec 6. Nat Metab. 2021. PMID: 34873337 Free article.
Elovl5 is required for proper action potential conduction along peripheral myelinated fibers.
Hoxha E, Balbo I, Parolisi R, Audano M, Montarolo F, Ravera F, Guglielmotto M, Muratori L, Raimondo S, DiGregorio E, Buffo A, Brusco A, Borroni B, Mitro N, Caruso D, Tempia F. Hoxha E, et al. Among authors: mitro n. Glia. 2021 Oct;69(10):2419-2428. doi: 10.1002/glia.24048. Epub 2021 Jun 17. Glia. 2021. PMID: 34139039 Free PMC article.
PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction.
Da Dalt L, Castiglioni L, Baragetti A, Audano M, Svecla M, Bonacina F, Pedretti S, Uboldi P, Benzoni P, Giannetti F, Barbuti A, Pellegatta F, Indino S, Donetti E, Sironi L, Mitro N, Catapano AL, Norata GD. Da Dalt L, et al. Among authors: mitro n. Eur Heart J. 2021 Aug 21;42(32):3078-3090. doi: 10.1093/eurheartj/ehab431. Eur Heart J. 2021. PMID: 34252181 Free PMC article.
Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis.
Palma C, La Rocca C, Gigantino V, Aquino G, Piccaro G, Di Silvestre D, Brambilla F, Rossi R, Bonacina F, Lepore MT, Audano M, Mitro N, Botti G, Bruzzaniti S, Fusco C, Procaccini C, De Rosa V, Galgani M, Alviggi C, Puca A, Grassi F, Rezzonico-Jost T, Norata GD, Mauri P, Netea MG, de Candia P, Matarese G. Palma C, et al. Among authors: mitro n. Cell Metab. 2021 Feb 2;33(2):300-318.e12. doi: 10.1016/j.cmet.2020.12.016. Epub 2021 Jan 8. Cell Metab. 2021. PMID: 33421383 Free article.
Metabolic control of DNA methylation in naive pluripotent cells.
Betto RM, Diamante L, Perrera V, Audano M, Rapelli S, Lauria A, Incarnato D, Arboit M, Pedretti S, Rigoni G, Guerineau V, Touboul D, Stirparo GG, Lohoff T, Boroviak T, Grumati P, Soriano ME, Nichols J, Mitro N, Oliviero S, Martello G. Betto RM, et al. Among authors: mitro n. Nat Genet. 2021 Feb;53(2):215-229. doi: 10.1038/s41588-020-00770-2. Epub 2021 Feb 1. Nat Genet. 2021. PMID: 33526924 Free PMC article.
Low-protein/high-carbohydrate diet induces AMPK-dependent canonical and non-canonical thermogenesis in subcutaneous adipose tissue.
Aquilano K, Sciarretta F, Turchi R, Li BH, Rosina M, Ceci V, Guidobaldi G, Arena S, D'Ambrosio C, Audano M, Salvatori I, Colella B, Faraonio R, Panebianco C, Pazienza V, Caruso D, Mitro N, Di Bartolomeo S, Scaloni A, Li JY, Lettieri-Barbato D. Aquilano K, et al. Among authors: mitro n. Redox Biol. 2020 Sep;36:101633. doi: 10.1016/j.redox.2020.101633. Epub 2020 Jul 9. Redox Biol. 2020. PMID: 32863211 Free PMC article.
DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering.
Milanese C, Bombardieri CR, Sepe S, Barnhoorn S, Payán-Goméz C, Caruso D, Audano M, Pedretti S, Vermeij WP, Brandt RMC, Gyenis A, Wamelink MM, de Wit AS, Janssens RC, Leen R, van Kuilenburg ABP, Mitro N, Hoeijmakers JHJ, Mastroberardino PG. Milanese C, et al. Among authors: mitro n. Nat Commun. 2019 Oct 25;10(1):4887. doi: 10.1038/s41467-019-12640-5. Nat Commun. 2019. PMID: 31653834 Free PMC article.
Ketogenic Diet: A New Light Shining on Old but Gold Biochemistry.
Longo R, Peri C, Cricrì D, Coppi L, Caruso D, Mitro N, De Fabiani E, Crestani M. Longo R, et al. Among authors: mitro n. Nutrients. 2019 Oct 17;11(10):2497. doi: 10.3390/nu11102497. Nutrients. 2019. PMID: 31627352 Free PMC article. Review.
Long-term efficacy of docosahexaenoic acid (DHA) for Spinocerebellar Ataxia 38 (SCA38) treatment: An open label extension study.
Manes M, Alberici A, Di Gregorio E, Boccone L, Premi E, Mitro N, Pasolini MP, Pani C, Paghera B, Orsi L, Costanzi C, Ferrero M, Tempia F, Caruso D, Padovani A, Brusco A, Borroni B. Manes M, et al. Among authors: mitro n. Parkinsonism Relat Disord. 2019 Jun;63:191-194. doi: 10.1016/j.parkreldis.2019.02.040. Epub 2019 Mar 7. Parkinsonism Relat Disord. 2019. PMID: 30862453 Free article. Clinical Trial.
Enhanced axonal neuregulin-1 type-III signaling ameliorates neurophysiology and hypomyelination in a Charcot-Marie-Tooth type 1B mouse model.
Scapin C, Ferri C, Pettinato E, Zambroni D, Bianchi F, Del Carro U, Belin S, Caruso D, Mitro N, Pellegatta M, Taveggia C, Schwab MH, Nave KA, Feltri ML, Wrabetz L, D'Antonio M. Scapin C, et al. Among authors: mitro n. Hum Mol Genet. 2019 Mar 15;28(6):992-1006. doi: 10.1093/hmg/ddy411. Hum Mol Genet. 2019. PMID: 30481294 Free PMC article.
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation.
Bonacina F, Coe D, Wang G, Longhi MP, Baragetti A, Moregola A, Garlaschelli K, Uboldi P, Pellegatta F, Grigore L, Da Dalt L, Annoni A, Gregori S, Xiao Q, Caruso D, Mitro N, Catapano AL, Marelli-Berg FM, Norata GD. Bonacina F, et al. Among authors: mitro n. Nat Commun. 2018 Aug 6;9(1):3083. doi: 10.1038/s41467-018-05322-1. Nat Commun. 2018. PMID: 30082772 Free PMC article.
Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth.
Pacella I, Procaccini C, Focaccetti C, Miacci S, Timperi E, Faicchia D, Severa M, Rizzo F, Coccia EM, Bonacina F, Mitro N, Norata GD, Rossetti G, Ranzani V, Pagani M, Giorda E, Wei Y, Matarese G, Barnaba V, Piconese S. Pacella I, et al. Among authors: mitro n. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6546-E6555. doi: 10.1073/pnas.1720113115. Epub 2018 Jun 25. Proc Natl Acad Sci U S A. 2018. PMID: 29941600 Free PMC article.
Fenofibrate attenuates cardiac and renal alterations in young salt-loaded spontaneously hypertensive stroke-prone rats through mitochondrial protection.
Castiglioni L, Pignieri A, Fiaschè M, Giudici M, Crestani M, Mitro N, Abbate M, Zoja C, Rottoli D, Foray C, Fiordaliso F, Guerrini U, Tremoli E, Sironi L, Gelosa P. Castiglioni L, et al. Among authors: mitro n. J Hypertens. 2018 May;36(5):1129-1146. doi: 10.1097/HJH.0000000000001651. J Hypertens. 2018. PMID: 29278547
PPAR Agonists and Metabolic Syndrome: An Established Role?
Botta M, Audano M, Sahebkar A, Sirtori CR, Mitro N, Ruscica M. Botta M, et al. Among authors: mitro n. Int J Mol Sci. 2018 Apr 14;19(4):1197. doi: 10.3390/ijms19041197. Int J Mol Sci. 2018. PMID: 29662003 Free PMC article. Review.
Zc3h10 is a novel mitochondrial regulator.
Audano M, Pedretti S, Cermenati G, Brioschi E, Diaferia GR, Ghisletti S, Cuomo A, Bonaldi T, Salerno F, Mora M, Grigore L, Garlaschelli K, Baragetti A, Bonacina F, Catapano AL, Norata GD, Crestani M, Caruso D, Saez E, De Fabiani E, Mitro N. Audano M, et al. Among authors: mitro n. EMBO Rep. 2018 Apr;19(4):e45531. doi: 10.15252/embr.201745531. Epub 2018 Mar 5. EMBO Rep. 2018. PMID: 29507079 Free PMC article.
Neuroactive steroids and diabetic complications in the nervous system.
Giatti S, Mastrangelo R, D'Antonio M, Pesaresi M, Romano S, Diviccaro S, Caruso D, Mitro N, Melcangi RC. Giatti S, et al. Among authors: mitro n. Front Neuroendocrinol. 2018 Jan;48:58-69. doi: 10.1016/j.yfrne.2017.07.006. Epub 2017 Jul 21. Front Neuroendocrinol. 2018. PMID: 28739507 Review.
Motor Deficits and Cerebellar Atrophy in Elovl5 Knock Out Mice.
Hoxha E, Gabriele RMC, Balbo I, Ravera F, Masante L, Zambelli V, Albergo C, Mitro N, Caruso D, Di Gregorio E, Brusco A, Borroni B, Tempia F. Hoxha E, et al. Among authors: mitro n. Front Cell Neurosci. 2017 Oct 30;11:343. doi: 10.3389/fncel.2017.00343. eCollection 2017. Front Cell Neurosci. 2017. PMID: 29163054 Free PMC article.
Docosahexaenoic acid is a beneficial replacement treatment for spinocerebellar ataxia 38.
Manes M, Alberici A, Di Gregorio E, Boccone L, Premi E, Mitro N, Pasolini MP, Pani C, Paghera B, Perani D, Orsi L, Costanzi C, Ferrero M, Zoppo A, Tempia F, Caruso D, Grassi M, Padovani A, Brusco A, Borroni B. Manes M, et al. Among authors: mitro n. Ann Neurol. 2017 Oct;82(4):615-621. doi: 10.1002/ana.25059. Epub 2017 Oct 22. Ann Neurol. 2017. PMID: 28976605 Free PMC article. Clinical Trial.
Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals.
Mauro C, Smith J, Cucchi D, Coe D, Fu H, Bonacina F, Baragetti A, Cermenati G, Caruso D, Mitro N, Catapano AL, Ammirati E, Longhi MP, Okkenhaug K, Norata GD, Marelli-Berg FM. Mauro C, et al. Among authors: mitro n. Cell Metab. 2017 Mar 7;25(3):593-609. doi: 10.1016/j.cmet.2017.01.008. Epub 2017 Feb 9. Cell Metab. 2017. PMID: 28190771 Free PMC article.
Short-term effects of diabetes on neurosteroidogenesis in the rat hippocampus.
Romano S, Mitro N, Diviccaro S, Spezzano R, Audano M, Garcia-Segura LM, Caruso D, Melcangi RC. Romano S, et al. Among authors: mitro n. J Steroid Biochem Mol Biol. 2017 Mar;167:135-143. doi: 10.1016/j.jsbmb.2016.11.019. Epub 2016 Nov 23. J Steroid Biochem Mol Biol. 2017. PMID: 27890531
Inter-Laboratory Robustness of Next-Generation Bile Acid Study in Mice and Humans: International Ring Trial Involving 12 Laboratories.
Pham HT, Arnhard K, Asad YJ, Deng L, Felder TK, St John-Williams L, Kaever V, Leadley M, Mitro N, Muccio S, Prehn C, Rauh M, Rolle-Kampczyk U, Thompson JW, Uhl O, Ulaszewska M, Vogeser M, Wishart DS, Koal T. Pham HT, et al. Among authors: mitro n. J Appl Lab Med. 2016 Sep 1;1(2):129-142. doi: 10.1373/jalm.2016.020537. J Appl Lab Med. 2016. PMID: 33626781
FABP1 in wonderland.
Prinetti A, Mitro N. Prinetti A, et al. Among authors: mitro n. J Neurochem. 2016 Aug;138(3):371-3. doi: 10.1111/jnc.13685. Epub 2016 Jun 22. J Neurochem. 2016. PMID: 27329821 Free article.
Clinical and neuroradiological features of spinocerebellar ataxia 38 (SCA38).
Borroni B, Di Gregorio E, Orsi L, Vaula G, Costanzi C, Tempia F, Mitro N, Caruso D, Manes M, Pinessi L, Padovani A, Brusco A, Boccone L. Borroni B, et al. Among authors: mitro n. Parkinsonism Relat Disord. 2016 Jul;28:80-6. doi: 10.1016/j.parkreldis.2016.04.030. Epub 2016 Apr 27. Parkinsonism Relat Disord. 2016. PMID: 27143115 Free PMC article.
An Essential Role for Liver ERα in Coupling Hepatic Metabolism to the Reproductive Cycle.
Della Torre S, Mitro N, Fontana R, Gomaraschi M, Favari E, Recordati C, Lolli F, Quagliarini F, Meda C, Ohlsson C, Crestani M, Uhlenhaut NH, Calabresi L, Maggi A. Della Torre S, et al. Among authors: mitro n. Cell Rep. 2016 Apr 12;15(2):360-71. doi: 10.1016/j.celrep.2016.03.019. Epub 2016 Mar 31. Cell Rep. 2016. PMID: 27050513 Free PMC article.
Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.
Dinamarca MC, Guzzetti F, Karpova A, Lim D, Mitro N, Musardo S, Mellone M, Marcello E, Stanic J, Samaddar T, Burguière A, Caldarelli A, Genazzani AA, Perroy J, Fagni L, Canonico PL, Kreutz MR, Gardoni F, Di Luca M. Dinamarca MC, et al. Among authors: mitro n. Elife. 2016 Mar 15;5:e12430. doi: 10.7554/eLife.12430. Elife. 2016. PMID: 26977767 Free PMC article.
Neuroactive steroids and the peripheral nervous system: An update.
Giatti S, Romano S, Pesaresi M, Cermenati G, Mitro N, Caruso D, Tetel MJ, Garcia-Segura LM, Melcangi RC. Giatti S, et al. Among authors: mitro n. Steroids. 2015 Nov;103:23-30. doi: 10.1016/j.steroids.2015.03.014. Epub 2015 Mar 28. Steroids. 2015. PMID: 25824325 Free PMC article. Review.
The lipogenic regulator Sterol Regulatory Element Binding Factor-1c is required to maintain peripheral nerve structure and function.
Mitro N, Cermenati G, Audano M, Giatti S, D'Antonio M, Fabiani ED, Crestani M, Saez E, Azcoitia I, Cavaletti G, Garcia-Segura LM, Melcangi RC, Caruso D. Mitro N, et al. Springerplus. 2015 Jun 12;4(Suppl 1):L45. doi: 10.1186/2193-1801-4-S1-L45. eCollection 2015. Springerplus. 2015. PMID: 27386207 Free PMC article. No abstract available.
Lack of sterol regulatory element binding factor-1c imposes glial Fatty Acid utilization leading to peripheral neuropathy.
Cermenati G, Audano M, Giatti S, Carozzi V, Porretta-Serapiglia C, Pettinato E, Ferri C, D'Antonio M, De Fabiani E, Crestani M, Scurati S, Saez E, Azcoitia I, Cavaletti G, Garcia-Segura LM, Melcangi RC, Caruso D, Mitro N. Cermenati G, et al. Among authors: mitro n. Cell Metab. 2015 Apr 7;21(4):571-83. doi: 10.1016/j.cmet.2015.02.016. Epub 2015 Mar 26. Cell Metab. 2015. PMID: 25817536 Free article.
ELOVL5 mutations cause spinocerebellar ataxia 38.
Di Gregorio E, Borroni B, Giorgio E, Lacerenza D, Ferrero M, Lo Buono N, Ragusa N, Mancini C, Gaussen M, Calcia A, Mitro N, Hoxha E, Mura I, Coviello DA, Moon YA, Tesson C, Vaula G, Couarch P, Orsi L, Duregon E, Papotti MG, Deleuze JF, Imbert J, Costanzi C, Padovani A, Giunti P, Maillet-Vioud M, Durr A, Brice A, Tempia F, Funaro A, Boccone L, Caruso D, Stevanin G, Brusco A. Di Gregorio E, et al. Among authors: mitro n. Am J Hum Genet. 2014 Aug 7;95(2):209-17. doi: 10.1016/j.ajhg.2014.07.001. Epub 2014 Jul 24. Am J Hum Genet. 2014. PMID: 25065913 Free PMC article.
LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties.
Gilardi F, Giudici M, Mitro N, Maschi O, Guerrini U, Rando G, Maggi A, Cermenati G, Laghezza A, Loiodice F, Pochetti G, Lavecchia A, Caruso D, De Fabiani E, Bamberg K, Crestani M. Gilardi F, et al. Among authors: mitro n. J Biol Chem. 2014 Mar 7;289(10):6908-6920. doi: 10.1074/jbc.M113.506394. Epub 2014 Jan 22. J Biol Chem. 2014. PMID: 24451380 Free PMC article.
Liver X receptors, nervous system, and lipid metabolism.
Cermenati G, Brioschi E, Abbiati F, Melcangi RC, Caruso D, Mitro N. Cermenati G, et al. Among authors: mitro n. J Endocrinol Invest. 2013 Jun;36(6):435-43. doi: 10.3275/8941. Epub 2013 Apr 18. J Endocrinol Invest. 2013. PMID: 23609963 Free article. Review.
Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue.
Galmozzi A, Mitro N, Ferrari A, Gers E, Gilardi F, Godio C, Cermenati G, Gualerzi A, Donetti E, Rotili D, Valente S, Guerrini U, Caruso D, Mai A, Saez E, De Fabiani E, Crestani M. Galmozzi A, et al. Among authors: mitro n. Diabetes. 2013 Mar;62(3):732-42. doi: 10.2337/db12-0548. Epub 2012 Oct 15. Diabetes. 2013. PMID: 23069623 Free PMC article.
Linking epigenetics to lipid metabolism: focus on histone deacetylases.
Ferrari A, Fiorino E, Giudici M, Gilardi F, Galmozzi A, Mitro N, Cermenati G, Godio C, Caruso D, De Fabiani E, Crestani M. Ferrari A, et al. Among authors: mitro n. Mol Membr Biol. 2012 Nov;29(7):257-66. doi: 10.3109/09687688.2012.729094. Epub 2012 Oct 24. Mol Membr Biol. 2012. PMID: 23095054 Free article. Review.
Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation.
Cermenati G, Abbiati F, Cermenati S, Brioschi E, Volonterio A, Cavaletti G, Saez E, De Fabiani E, Crestani M, Garcia-Segura LM, Melcangi RC, Caruso D, Mitro N. Cermenati G, et al. Among authors: mitro n. J Lipid Res. 2012 Feb;53(2):300-10. doi: 10.1194/jlr.M021188. Epub 2011 Dec 7. J Lipid Res. 2012. PMID: 22158827 Free PMC article.
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.
Porcelli L, Gilardi F, Laghezza A, Piemontese L, Mitro N, Azzariti A, Altieri F, Cervoni L, Fracchiolla G, Giudici M, Guerrini U, Lavecchia A, Montanari R, Di Giovanni C, Paradiso A, Pochetti G, Simone GM, Tortorella P, Crestani M, Loiodice F. Porcelli L, et al. Among authors: mitro n. J Med Chem. 2012 Jan 12;55(1):37-54. doi: 10.1021/jm201306q. Epub 2011 Dec 2. J Med Chem. 2012. PMID: 22081932
Role of neuroactive steroids in the peripheral nervous system.
Melcangi RC, Giatti S, Pesaresi M, Calabrese D, Mitro N, Caruso D, Garcia-Segura LM. Melcangi RC, et al. Among authors: mitro n. Front Endocrinol (Lausanne). 2011 Dec 27;2:104. doi: 10.3389/fendo.2011.00104. eCollection 2011. Front Endocrinol (Lausanne). 2011. PMID: 22654839 Free PMC article.
Structural insight into peroxisome proliferator-activated receptor gamma binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesis.
Pochetti G, Mitro N, Lavecchia A, Gilardi F, Besker N, Scotti E, Aschi M, Re N, Fracchiolla G, Laghezza A, Tortorella P, Montanari R, Novellino E, Mazza F, Crestani M, Loiodice F. Pochetti G, et al. Among authors: mitro n. J Med Chem. 2010 Jun 10;53(11):4354-66. doi: 10.1021/jm9013899. J Med Chem. 2010. PMID: 20462215
When food meets man: the contribution of epigenetics to health.
De Fabiani E, Mitro N, Gilardi F, Galmozzi A, Caruso D, Crestani M. De Fabiani E, et al. Among authors: mitro n. Nutrients. 2010 May;2(5):551-71. doi: 10.3390/nu2050551. Epub 2010 May 25. Nutrients. 2010. PMID: 22254041 Free PMC article. Review.
Gene set enrichment in eQTL data identifies novel annotations and pathway regulators.
Wu C, Delano DL, Mitro N, Su SV, Janes J, McClurg P, Batalov S, Welch GL, Zhang J, Orth AP, Walker JR, Glynne RJ, Cooke MP, Takahashi JS, Shimomura K, Kohsaka A, Bass J, Saez E, Wiltshire T, Su AI. Wu C, et al. Among authors: mitro n. PLoS Genet. 2008 May 9;4(5):e1000070. doi: 10.1371/journal.pgen.1000070. PLoS Genet. 2008. PMID: 18464898 Free PMC article.
Dissection of the insulin-sensitizing effect of liver X receptor ligands.
Commerford SR, Vargas L, Dorfman SE, Mitro N, Rocheford EC, Mak PA, Li X, Kennedy P, Mullarkey TL, Saez E. Commerford SR, et al. Among authors: mitro n. Mol Endocrinol. 2007 Dec;21(12):3002-12. doi: 10.1210/me.2007-0156. Epub 2007 Aug 23. Mol Endocrinol. 2007. PMID: 17717069
N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.
Molteni V, Li X, Nabakka J, Liang F, Wityak J, Koder A, Vargas L, Romeo R, Mitro N, Mak PA, Seidel HM, Haslam JA, Chow D, Tuntland T, Spalding TA, Brock A, Bradley M, Castrillo A, Tontonoz P, Saez E. Molteni V, et al. Among authors: mitro n. J Med Chem. 2007 Aug 23;50(17):4255-9. doi: 10.1021/jm070453f. Epub 2007 Aug 1. J Med Chem. 2007. PMID: 17665897
Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands.
Pochetti G, Godio C, Mitro N, Caruso D, Galmozzi A, Scurati S, Loiodice F, Fracchiolla G, Tortorella P, Laghezza A, Lavecchia A, Novellino E, Mazza F, Crestani M. Pochetti G, et al. Among authors: mitro n. J Biol Chem. 2007 Jun 8;282(23):17314-24. doi: 10.1074/jbc.M702316200. Epub 2007 Apr 2. J Biol Chem. 2007. PMID: 17403688 Free article.
Age-related changes in bile acid synthesis and hepatic nuclear receptor expression.
Bertolotti M, Gabbi C, Anzivino C, Crestani M, Mitro N, Del Puppo M, Godio C, De Fabiani E, Macchioni D, Carulli L, Rossi A, Ricchi M, Loria P, Carulli N. Bertolotti M, et al. Among authors: mitro n. Eur J Clin Invest. 2007 Jun;37(6):501-8. doi: 10.1111/j.1365-2362.2007.01808.x. Eur J Clin Invest. 2007. PMID: 17537158 Free article.
The nuclear receptor LXR is a glucose sensor.
Mitro N, Mak PA, Vargas L, Godio C, Hampton E, Molteni V, Kreusch A, Saez E. Mitro N, et al. Nature. 2007 Jan 11;445(7124):219-23. doi: 10.1038/nature05449. Epub 2006 Dec 24. Nature. 2007. PMID: 17187055
The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors.
De Fabiani E, Mitro N, Anzulovich AC, Pinelli A, Galli G, Crestani M. De Fabiani E, et al. Among authors: mitro n. J Biol Chem. 2001 Aug 17;276(33):30708-16. doi: 10.1074/jbc.M103270200. Epub 2001 Jun 11. J Biol Chem. 2001. PMID: 11402042 Free article.