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Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival.
Cho HR, Kwon B, Yagita H, La S, Lee EA, Kim JE, Akiba H, Kim J, Suh JH, Vinay DS, Ju SA, Kim BS, Mittler RS, Okumura K, Kwon BS. Cho HR, et al. Among authors: mittler rs. Transpl Int. 2004 Aug;17(7):351-61. doi: 10.1007/s00147-004-0726-3. Epub 2004 Jul 31. Transpl Int. 2004. PMID: 15349720
4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses.
Shuford WW, Klussman K, Tritchler DD, Loo DT, Chalupny J, Siadak AW, Brown TJ, Emswiler J, Raecho H, Larsen CP, Pearson TC, Ledbetter JA, Aruffo A, Mittler RS. Shuford WW, et al. Among authors: mittler rs. J Exp Med. 1997 Jul 7;186(1):47-55. doi: 10.1084/jem.186.1.47. J Exp Med. 1997. PMID: 9206996 Free PMC article.
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