Theobromine, the primary methylxanthine found in Theobroma cacao, prevents malignant glioblastoma proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of rapamycin kinase, and nuclear factor-kappa B.
Nutr Cancer. 2014;66(3):419-23. doi: 10.1080/01635581.2013.877497. Epub 2014 Feb 18.
Nutr Cancer. 2014.
PMID: 24547961