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Hesr2 knockout mice develop aortic valve disease with advancing age.
Kokubo H, Miyagawa-Tomita S, Nakashima Y, Kume T, Yoshizumi M, Nakanishi T, Saga Y. Kokubo H, et al. Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):e84-92. doi: 10.1161/ATVBAHA.112.300573. Epub 2013 Jan 3. Arterioscler Thromb Vasc Biol. 2013. PMID: 23288164
Hesr, a mediator of the Notch signaling, functions in heart and vessel development.
Kokubo H, Miyagawa-Tomita S, Johnson RL. Kokubo H, et al. Trends Cardiovasc Med. 2005 Jul;15(5):190-4. doi: 10.1016/j.tcm.2005.05.005. Trends Cardiovasc Med. 2005. PMID: 16165016 Review.
Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction.
Kokubo H, Miyagawa-Tomita S, Tomimatsu H, Nakashima Y, Nakazawa M, Saga Y, Johnson RL. Kokubo H, et al. Circ Res. 2004 Sep 3;95(5):540-7. doi: 10.1161/01.RES.0000141136.85194.f0. Epub 2004 Aug 5. Circ Res. 2004. PMID: 15297376
Postotic and preotic cranial neural crest cells differently contribute to thyroid development.
Maeda K, Asai R, Maruyama K, Kurihara Y, Nakanishi T, Kurihara H, Miyagawa-Tomita S. Maeda K, et al. Among authors: miyagawa tomita s. Dev Biol. 2016 Jan 1;409(1):72-83. doi: 10.1016/j.ydbio.2015.10.026. Epub 2015 Oct 23. Dev Biol. 2016. PMID: 26506449 Free article.
Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process.
Kitazawa T, Fujisawa K, Narboux-NĂªme N, Arima Y, Kawamura Y, Inoue T, Wada Y, Kohro T, Aburatani H, Kodama T, Kim KS, Sato T, Uchijima Y, Maeda K, Miyagawa-Tomita S, Minoux M, Rijli FM, Levi G, Kurihara Y, Kurihara H. Kitazawa T, et al. Dev Biol. 2015 Jun 15;402(2):162-74. doi: 10.1016/j.ydbio.2015.04.007. Epub 2015 Apr 16. Dev Biol. 2015. PMID: 25889273
Mesp1-nonexpressing cells contribute to the ventricular cardiac conduction system.
Kitajima S, Miyagawa-Tomita S, Inoue T, Kanno J, Saga Y. Kitajima S, et al. Dev Dyn. 2006 Feb;235(2):395-402. doi: 10.1002/dvdy.20640. Dev Dyn. 2006. PMID: 16317723
Mesp1 expression is the earliest sign of cardiovascular development.
Saga Y, Kitajima S, Miyagawa-Tomita S. Saga Y, et al. Trends Cardiovasc Med. 2000 Nov;10(8):345-52. doi: 10.1016/s1050-1738(01)00069-x. Trends Cardiovasc Med. 2000. PMID: 11369261 Review.
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