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Oncostatin M, a multifunctional cytokine.
Tanaka M, Miyajima A. Tanaka M, et al. Rev Physiol Biochem Pharmacol. 2003;149:39-52. doi: 10.1007/s10254-003-0013-1. Epub 2003 Jun 17. Rev Physiol Biochem Pharmacol. 2003. PMID: 12811586 Review.
Oncostatin M (OSM) is a multifunctional cytokine that belongs to the Interleukin (IL)-6 subfamily. Among the family members, OSM is most closely related to leukemia inhibitory factor (LIF) and it in fact utilizes the LIF receptor in addition to its specific receptor in the …
Oncostatin M (OSM) is a multifunctional cytokine that belongs to the Interleukin (IL)-6 subfamily. Among the family members, OSM is m …
Differentiation inducers modulate cytokine signaling pathways in a murine erythroleukemia cell line.
Yamashita T, Wakao H, Miyajima A, Asano S. Yamashita T, et al. Cancer Res. 1998 Feb 1;58(3):556-61. Cancer Res. 1998. PMID: 9458105
Hexamethylenebisacetamide (HMBA) is a potent differentiation inducer of murine erythroleukemia cells. Immunoprecipitation followed by Western blotting with an anti-phosphotyrosine (P-Tyr) antibody revealed that HMBA increased P-Tyr levels and/or amounts of several proteins …
Hexamethylenebisacetamide (HMBA) is a potent differentiation inducer of murine erythroleukemia cells. Immunoprecipitation followed by …
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.
Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A. Yoshimura A, et al. EMBO J. 1995 Jun 15;14(12):2816-26. EMBO J. 1995. PMID: 7796808 Free PMC article.
The CIS message encodes a polypeptide of 257 amino acids that contains an SH2 domain of 96 amino acids in the middle. To clarify the function of CIS in cytokine signal transduction, we expressed CIS in IL3-dependent hematopoietic cell lines under the control of a st …
The CIS message encodes a polypeptide of 257 amino acids that contains an SH2 domain of 96 amino acids in the middle. To clarify the …
Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. I. Production, isolation and biological activity.
Murakami R, Tomikawa T, Shin-ya K, Shinozaki J, Kajiura T, Kinoshita T, Miyajima A, Seto H, Hayakawa Y. Murakami R, et al. J Antibiot (Tokyo). 2001 Sep;54(9):710-3. doi: 10.7164/antibiotics.54.710. J Antibiot (Tokyo). 2001. PMID: 11714226
A new apoptosis inducer, ammocidin, was isolated from the culture broth of Saccharothrix sp. AJ9571. Ammocidin induced apoptotic cell death in Ras-dependent Ba/F3-V12 cells with an IC50 of 66 ng/ml. ...
A new apoptosis inducer, ammocidin, was isolated from the culture broth of Saccharothrix sp. AJ9571. Ammocidin induced apoptotic cell
Distinct roles of oncostatin M and leukemia inhibitory factor in the development of primordial germ cells and sertoli cells in mice.
Hara T, Tamura K, de Miguel MP, Mukouyama Y, Kim Hj, Kogo H, Donovan PJ, Miyajima A. Hara T, et al. Dev Biol. 1998 Sep 15;201(2):144-53. doi: 10.1006/dbio.1998.8990. Dev Biol. 1998. PMID: 9740655
These results indicate that mOSM is a stage- and sex-specific autocrine growth factor for Sertoli cells....
These results indicate that mOSM is a stage- and sex-specific autocrine growth factor for Sertoli cells....
Hematopoietic cells in cultures of the murine embryonic aorta-gonad-mesonephros region are induced by c-Myb.
Mukouyama Ys, Chiba N, Mucenski ML, Satake M, Miyajima A, Hara T, Watanabe T. Mukouyama Ys, et al. Curr Biol. 1999 Jul 29-Aug 12;9(15):833-6. doi: 10.1016/s0960-9822(99)80368-6. Curr Biol. 1999. PMID: 10469571
When infected with a retrovirus carrying c-myb cDNA, these cultures gave rise to a significant number of hematopoietic cells. ...Thus, c-Myb plays a role in the generation of hematopoietic cells in the embryonic P-Sp and AGM regions....
When infected with a retrovirus carrying c-myb cDNA, these cultures gave rise to a significant number of hematopoietic cells. …
Signal transduction by the GM-CSF, IL-3 and IL-5 receptors.
Miyajima A, Kinoshita T, Wakao H, Hara T, Yoshimura A, Nishinakamura R, Murray R, Mui A. Miyajima A, et al. Leukemia. 1997 Apr;11 Suppl 3:418-22. Leukemia. 1997. PMID: 9209411 Review. No abstract available.
Regulation of tissue inhibitor of metalloproteinase-1 in fibroblasts and acute phase proteins in hepatocytes in vitro by mouse oncostatin M, cardiotrophin-1, and IL-6.
Richards CD, Kerr C, Tanaka M, Hara T, Miyajima A, Pennica D, Botelho F, Langdon CM. Richards CD, et al. J Immunol. 1997 Sep 1;159(5):2431-7. J Immunol. 1997. PMID: 9278335
Similarly, only mOSM was able to induce transcription of chloramphenicol acetyl-transferase (CAT) in NIH-3T3 cells transfected with a minimal TIMP-1 promoter/CAT construct. ...These results indicate that mOSM does not share a functional receptor with mCT-1 or hOSM i …
Similarly, only mOSM was able to induce transcription of chloramphenicol acetyl-transferase (CAT) in NIH-3T3 cells transfected with a
Cytokine receptors and signal transduction.
Miyajima A, Kitamura T, Harada N, Yokota T, Arai K. Miyajima A, et al. Annu Rev Immunol. 1992;10:295-331. doi: 10.1146/annurev.iy.10.040192.001455. Annu Rev Immunol. 1992. PMID: 1590989 Review.
Cytokines play a vital role in coordinating immune and inflammatory responses. Unlike growth factor receptors with a tyrosine kinase, cytokine receptors have no intrinsic tyrosine kinase activity. ...
Cytokines play a vital role in coordinating immune and inflammatory responses. Unlike growth factor receptors with a tyrosine …
Common subunits of cytokine receptors and the functional redundancy of cytokines.
Miyajima A, Hara T, Kitamura T. Miyajima A, et al. Trends Biochem Sci. 1992 Oct;17(10):378-82. doi: 10.1016/0968-0004(92)90004-s. Trends Biochem Sci. 1992. PMID: 1455505 Review.
The findings that high-affinity receptors for a group of cytokines with similar function share a common subunit with a critical role in signal transduction have provided a molecular basis for the functional redundancy of cytokines. ...
The findings that high-affinity receptors for a group of cytokines with similar function share a common subunit with a
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