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231 results
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Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymerase β.
Kuriyama I, Miyazaki A, Tsuda Y, Yoshida H, Mizushina Y. Kuriyama I, et al. Bioorg Med Chem. 2013 Jan 15;21(2):403-11. doi: 10.1016/j.bmc.2012.11.024. Epub 2012 Nov 29. Bioorg Med Chem. 2013. PMID: 23266186
Synthesis, structure, and cytotoxicity studies of some fungal isochromanes.
Kuramochi K, Tsubaki K, Kuriyama I, Mizushina Y, Yoshida H, Takeuchi T, Kamisuki S, Sugawara F, Kobayashi S. Kuramochi K, et al. J Nat Prod. 2013 Sep 27;76(9):1737-45. doi: 10.1021/np400460m. Epub 2013 Sep 13. J Nat Prod. 2013. PMID: 24033077
Transformation of thiols to disulfides by epolactaene and its derivatives.
Kuramochi K, Sunoki T, Tsubaki K, Mizushina Y, Sakaguchi K, Sugawara F, Ikekita M, Kobayashi S. Kuramochi K, et al. Bioorg Med Chem. 2011 Jul 15;19(14):4162-72. doi: 10.1016/j.bmc.2011.06.015. Epub 2011 Jun 13. Bioorg Med Chem. 2011. PMID: 21708466
Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response.
Maruo S, Kuriyama I, Kuramochi K, Tsubaki K, Yoshida H, Mizushina Y. Maruo S, et al. Bioorg Med Chem. 2011 Oct 1;19(19):5803-12. doi: 10.1016/j.bmc.2011.08.023. Epub 2011 Aug 18. Bioorg Med Chem. 2011. PMID: 21903399
Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen.
Miyano Y, Tsukuda S, Sakimoto I, Takeuchi R, Shimura S, Takahashi N, Kusayanagi T, Takakusagi Y, Okado M, Matsumoto Y, Takakusagi K, Takeuchi T, Kamisuki S, Nakazaki A, Ohta K, Miura M, Kuramochi K, Mizushina Y, Kobayashi S, Sugawara F, Sakaguchi K. Miyano Y, et al. Bioorg Med Chem. 2012 Jul 1;20(13):3985-90. doi: 10.1016/j.bmc.2012.05.016. Epub 2012 May 15. Bioorg Med Chem. 2012. PMID: 22658539
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
Myobatake Y, Takeuchi T, Kuramochi K, Kuriyama I, Ishido T, Hirano K, Sugawara F, Yoshida H, Mizushina Y. Myobatake Y, et al. J Nat Prod. 2012 Feb 24;75(2):135-41. doi: 10.1021/np200523b. Epub 2012 Jan 20. J Nat Prod. 2012. PMID: 22264170
These compounds selectively inhibited the activities of mammalian DNA polymerases (pols), A (pol γ), B (pols α, δ, and ε), and Y (pols η, ι, and κ) families, but did not influence the activities of the four X-family pols (pols β, λ, μ, and terminal deoxynucleotidyl transfe …
These compounds selectively inhibited the activities of mammalian DNA polymerases (pols), A (pol γ), B (pols α, δ, and ε), and Y (pol …
Novel terpenoids, trichoderonic acids A and B isolated from Trichoderma virens, are selective inhibitors of family X DNA polymerases.
Yamaguchi Y, Manita D, Takeuchi T, Kuramochi K, Kuriyama I, Sugawara F, Yoshida H, Mizushina Y. Yamaguchi Y, et al. Biosci Biotechnol Biochem. 2010;74(4):793-801. doi: 10.1271/bbb.90843. Epub 2010 Apr 7. Biosci Biotechnol Biochem. 2010. PMID: 20378979
On the other hand, compounds 1-3 did not influence the activities of the other families (A-, B-, and the Y-families) of the mammalian pols tested, and showed no effect on the activities of plant pol alpha, fish pol delta, prokaryotic pol, or the other DNA metabolic enzymes …
On the other hand, compounds 1-3 did not influence the activities of the other families (A-, B-, and the Y-families) of the mammalian …
Syntheses and applications of fluorescent and biotinylated epolactaene derivatives: Epolactaene and its derivative induce disulfide formation.
Kuramochi K, Yukizawa S, Ikeda S, Sunoki T, Arai S, Matsui R, Morita A, Mizushina Y, Sakaguchi K, Sugawara F, Ikekita M, Kobayashi S. Kuramochi K, et al. Bioorg Med Chem. 2008 May 1;16(9):5039-49. doi: 10.1016/j.bmc.2008.03.029. Epub 2008 Mar 14. Bioorg Med Chem. 2008. PMID: 18375133
Novel azaphilones, kasanosins A and B, which are specific inhibitors of eukaryotic DNA polymerases beta and lambda from Talaromyces sp.
Kimura T, Nishida M, Kuramochi K, Sugawara F, Yoshida H, Mizushina Y. Kimura T, et al. Bioorg Med Chem. 2008 Apr 15;16(8):4594-9. doi: 10.1016/j.bmc.2008.02.037. Epub 2008 Feb 15. Bioorg Med Chem. 2008. PMID: 18308572
., pols alpha, delta, and epsilon) and family Y (i.e., pols eta, iota, and kappa), and showed no effect even on the activities of plant pol alpha, fish pol delta, prokaryotic pols, and other DNA metabolic enzymes, such as calf primase of pol alpha, human immunodeficiency v …
., pols alpha, delta, and epsilon) and family Y (i.e., pols eta, iota, and kappa), and showed no effect even on the activities of pla …
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