Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Text availability
Article attribute
Article type
Publication date

Search Results

21 results
Filters applied: . Clear all Results are displayed in a computed author sort order. Results by year timeline is unavailable
Page 1
Rational development of a high-affinity secretin receptor antagonist.
Dong M, Harikumar KG, Raval SR, Milburn JE, Clark C, Alcala-Torano R, Mobarec JC, Reynolds CA, Ghirlanda G, Christopoulos A, Wootten D, Sexton PM, Miller LJ. Dong M, et al. Among authors: Mobarec JC. Biochem Pharmacol. 2020 Mar 23;177:113929. doi: 10.1016/j.bcp.2020.113929. Online ahead of print. Biochem Pharmacol. 2020. PMID: 32217097
Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design.
O'Brien A, Andrews SP, Baig AH, Bortolato A, Brown AJH, Brown GA, Brown SH, Christopher JA, Congreve M, Cooke RM, De Graaf C, Errey JC, Fieldhouse C, Jazayeri A, Marshall FH, Mason JS, Mobarec JC, Okrasa K, Steele KN, Southall SM, Teobald I, Watson SP, Weir M. O'Brien A, et al. Among authors: Mobarec JC. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126611. doi: 10.1016/j.bmcl.2019.08.015. Epub 2019 Aug 9. Bioorg Med Chem Lett. 2019. PMID: 31447084
Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs.
Woolley MJ, Reynolds CA, Simms J, Walker CS, Mobarec JC, Garelja ML, Conner AC, Poyner DR, Hay DL. Woolley MJ, et al. Among authors: Mobarec JC. Biochem Pharmacol. 2017 Oct 15;142:96-110. doi: 10.1016/j.bcp.2017.07.005. Epub 2017 Jul 11. Biochem Pharmacol. 2017. PMID: 28705698 Free PMC article.
Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach.
Woolley MJ, Simms J, Mobarec JC, Reynolds CA, Poyner DR, Conner AC. Woolley MJ, et al. Among authors: Mobarec JC. Mol Cell Endocrinol. 2017 Oct 15;454:39-49. doi: 10.1016/j.mce.2017.05.034. Epub 2017 May 30. Mol Cell Endocrinol. 2017. PMID: 28572046
Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R).
Koole C, Reynolds CA, Mobarec JC, Hick C, Sexton PM, Sakmar TP. Koole C, et al. Among authors: Mobarec JC. J Biol Chem. 2017 Apr 28;292(17):7131-7144. doi: 10.1074/jbc.M117.779496. Epub 2017 Mar 10. J Biol Chem. 2017. PMID: 28283573 Free PMC article.
High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.
Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D. Weaver RE, et al. Among authors: Mobarec JC. Biochem Pharmacol. 2017 Mar 1;127:71-81. doi: 10.1016/j.bcp.2016.12.013. Epub 2016 Dec 22. Biochem Pharmacol. 2017. PMID: 28012961 Free PMC article.
Receptor activity-modifying protein-directed G protein signaling specificity for the calcitonin gene-related peptide family of receptors.
Weston C, Winfield I, Harris M, Hodgson R, Shah A, Dowell SJ, Mobarec JC, Woodcock DA, Reynolds CA, Poyner DR, Watkins HA, Ladds G. Weston C, et al. Among authors: Mobarec JC. J Biol Chem. 2016 Dec 2;291(49):25763. doi: 10.1074/jbc.A116.751362. J Biol Chem. 2016. PMID: 27913664 Free PMC article. No abstract available.
Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor.
Wootten D, Reynolds CA, Smith KJ, Mobarec JC, Furness SG, Miller LJ, Christopoulos A, Sexton PM. Wootten D, et al. Among authors: Mobarec JC. Biochem Pharmacol. 2016 Oct 15;118:68-87. doi: 10.1016/j.bcp.2016.08.015. Epub 2016 Aug 26. Biochem Pharmacol. 2016. PMID: 27569426 Free PMC article.
Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors.
Weston C, Winfield I, Harris M, Hodgson R, Shah A, Dowell SJ, Mobarec JC, Woodlock DA, Reynolds CA, Poyner DR, Watkins HA, Ladds G. Weston C, et al. Among authors: Mobarec JC. J Biol Chem. 2016 Oct 14;291(42):21925-21944. doi: 10.1074/jbc.M116.751362. Epub 2016 Aug 26. J Biol Chem. 2016. PMID: 27566546 Free PMC article.
The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism.
Wootten D, Reynolds CA, Smith KJ, Mobarec JC, Koole C, Savage EE, Pabreja K, Simms J, Sridhar R, Furness SGB, Liu M, Thompson PE, Miller LJ, Christopoulos A, Sexton PM. Wootten D, et al. Among authors: Mobarec JC. Cell. 2016 Jun 16;165(7):1632-1643. doi: 10.1016/j.cell.2016.05.023. Cell. 2016. PMID: 27315480 Free PMC article.
21 results
Jump to page
Feedback