Modeling of spatially-restricted intracellular signaling.
Wiley Interdiscip Rev Syst Biol Med. 2012.
PMID: 21766466
Free PMC article.
Review.
Search Page
Results by year
Table representation of search results timeline featuring number of search results per year.
| Year | Number of Results |
|---|---|
| 2000 | 1 |
| 2001 | 1 |
| 2005 | 2 |
| 2006 | 1 |
| 2008 | 1 |
| 2009 | 3 |
| 2010 | 1 |
| 2011 | 1 |
| 2012 | 2 |
| 2013 | 1 |
| 2014 | 2 |
| 2015 | 1 |
| 2016 | 3 |
| 2019 | 1 |
| 2021 | 0 |
Search Results
18
results
Results by year
Citations
1 article found by citation matchingSearch results
Filters applied: . Clear all
Page 1
Modeling of spatially-restricted intracellular signaling.
Wiley Interdiscip Rev Syst Biol Med. 2012 Jan-Feb;4(1):103-15. doi: 10.1002/wsbm.155. Epub 2011 Jul 15.
Wiley Interdiscip Rev Syst Biol Med. 2012.
PMID: 21766466
Free PMC article.
Review.
Understanding the signaling capabilities of a cell presents a major challenge, not only due to the number of molecules involved, but also because of the complex network connectivity of intracellular signaling. Recently, the proliferation of quantitative imagi …
Understanding the signaling capabilities of a cell presents a major challenge, not only due to the number of molecules involved, but …
Models of spatially restricted biochemical reaction systems.
J Biol Chem. 2009 Feb 27;284(9):5445-9. doi: 10.1074/jbc.R800058200. Epub 2008 Oct 20.
J Biol Chem. 2009.
PMID: 18940805
Free PMC article.
Review.
The mathematical models show that, for membrane-initiated signaling, the ratio of the surface area of the plasma membrane to the volume of the cytoplasm, the topology of the signaling network, the negative regulators, and kinetic properties of key comp …
The mathematical models show that, for membrane-initiated signaling, the ratio of the surface area of the plasma membrane to t …
A mechanism for temporary bioadhesion.
Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4297-4306. doi: 10.1073/pnas.1814230116. Epub 2019 Feb 19.
Proc Natl Acad Sci U S A. 2019.
PMID: 30782790
Free PMC article.
We revealed that both proteins are expressed in the adhesive gland cells and that their distribution within the adhesive footprints was spatially restricted. RNA interference knockdown experiments demonstrated the essential function of these two proteins in flatworm …
We revealed that both proteins are expressed in the adhesive gland cells and that their distribution within the adhesive footprints was s …
The Ras-ERK pathway: understanding site-specific signaling provides hope of new anti-tumor therapies.
Bioessays. 2010 May;32(5):412-21. doi: 10.1002/bies.200900155.
Bioessays. 2010.
PMID: 20414899
Review.
Recent discoveries have suggested the concept that intracellular signals are the sum of multiple, site-specified subsignals, rather than single, homogeneous entities. ...These findings may open a gate for aiming at the Ras-ERK pathway in a spatially restri …
Recent discoveries have suggested the concept that intracellular signals are the sum of multiple, site-specified subsignals, r …
Intracellular calcium signals display an avalanche-like behavior over multiple lengthscales.
Front Physiol. 2012 Sep 3;3:350. doi: 10.3389/fphys.2012.00350. eCollection 2012.
Front Physiol. 2012.
PMID: 22969730
Free PMC article.
Ca(2+) signals can either be spatially restricted (local) or propagate throughout the cell (global). ...In this paper we discuss these issues within the framework of simple models of Ca(2+) signal propagation. We also analyze the size distributi …
Ca(2+) signals can either be spatially restricted (local) or propagate throughout the cell (global). ...In this paper w …
Integrin-mediated activation of latent transforming growth factor beta.
Cancer Metastasis Rev. 2005 Sep;24(3):395-402. doi: 10.1007/s10555-005-5131-6.
Cancer Metastasis Rev. 2005.
PMID: 16258727
Review.
Members of the integrin family recognize a variety of spatially-restricted extracellular ligands. Classically, ligation of integrins activates cytoplasmic signals in the integrin-expressing cell and contributes to cell adhesion, migration, proliferation and s …
Members of the integrin family recognize a variety of spatially-restricted extracellular ligands. Classically, ligation of int …
CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.
Mol Cell. 2015 Mar 19;57(6):995-1010. doi: 10.1016/j.molcel.2014.12.040. Epub 2015 Feb 12.
Mol Cell. 2015.
PMID: 25684205
Free article.
The small Rho GTPase RAC1 is an essential regulator of cellular signaling that controls actin rearrangements and cell motility. Here, we identify a novel CUL3 RING ubiquitin ligase complex, containing the substrate adaptors KBTBD6 and KBTBD7, that mediates ubiquitylation a …
The small Rho GTPase RAC1 is an essential regulator of cellular signaling that controls actin rearrangements and cell motility. Here, …
The influence of Ca²⁺ buffers on free [Ca²⁺] fluctuations and the effective volume of Ca²⁺ microdomains.
Biophys J. 2014 Jun 17;106(12):2693-709. doi: 10.1016/j.bpj.2014.04.045.
Biophys J. 2014.
PMID: 24940787
Free PMC article.
Intracellular calcium (Ca(2+)) plays a significant role in many cell signaling pathways, some of which are localized to spatially restricted microdomains. ...Because fluctuations in [Ca(2+)] decrease in proportion to the square-root of a domain's …
Intracellular calcium (Ca(2+)) plays a significant role in many cell signaling pathways, some of which are localized to spa …
mRNA localization: message on the move.
Nat Rev Mol Cell Biol. 2001 Apr;2(4):247-56. doi: 10.1038/35067016.
Nat Rev Mol Cell Biol. 2001.
PMID: 11283722
Review.
Cytoplasmic messenger RNA localization is a key post-transcriptional mechanism of establishing spatially restricted protein synthesis. The characterization of cis-acting signals within localized mRNAs, and the identification of trans-acting factors that recog …
Cytoplasmic messenger RNA localization is a key post-transcriptional mechanism of establishing spatially restricted protein sy …
Microdomain [Ca(2+)] Fluctuations Alter Temporal Dynamics in Models of Ca(2+)-Dependent Signaling Cascades and Synaptic Vesicle Release.
Neural Comput. 2016 Mar;28(3):493-524. doi: 10.1162/NECO_a_00811. Epub 2016 Jan 6.
Neural Comput. 2016.
PMID: 26735745
Ca(2+)-dependent signaling is often localized in spatially restricted microdomains and may involve only 1 to 100 Ca(2+) ions. ...However, it is unclear to what extent these fluctuations alter Ca(2+)-dependent signaling. We construct Markov models …
Ca(2+)-dependent signaling is often localized in spatially restricted microdomains and may involve only 1 to 100 Ca(2+) …