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Year Number of Results
2000 1
2001 1
2005 2
2006 1
2008 1
2009 3
2010 1
2011 1
2012 2
2013 1
2014 2
2015 1
2016 3
2019 1
2022 0
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Modeling of spatially-restricted intracellular signaling.
Neves SR. Neves SR. Wiley Interdiscip Rev Syst Biol Med. 2012 Jan-Feb;4(1):103-15. doi: 10.1002/wsbm.155. Epub 2011 Jul 15. Wiley Interdiscip Rev Syst Biol Med. 2012. PMID: 21766466 Free PMC article. Review.
Understanding the signaling capabilities of a cell presents a major challenge, not only due to the number of molecules involved, but also because of the complex network connectivity of intracellular signaling. Recently, the proliferation of quantitative imagi …
Understanding the signaling capabilities of a cell presents a major challenge, not only due to the number of molecules involved, but …
Models of spatially restricted biochemical reaction systems.
Neves SR, Iyengar R. Neves SR, et al. J Biol Chem. 2009 Feb 27;284(9):5445-9. doi: 10.1074/jbc.R800058200. Epub 2008 Oct 20. J Biol Chem. 2009. PMID: 18940805 Free PMC article. Review.
The mathematical models show that, for membrane-initiated signaling, the ratio of the surface area of the plasma membrane to the volume of the cytoplasm, the topology of the signaling network, the negative regulators, and kinetic properties of key comp …
The mathematical models show that, for membrane-initiated signaling, the ratio of the surface area of the plasma membrane to t …
A mechanism for temporary bioadhesion.
Wunderer J, Lengerer B, Pjeta R, Bertemes P, Kremser L, Lindner H, Ederth T, Hess MW, Stock D, Salvenmoser W, Ladurner P. Wunderer J, et al. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4297-4306. doi: 10.1073/pnas.1814230116. Epub 2019 Feb 19. Proc Natl Acad Sci U S A. 2019. PMID: 30782790 Free PMC article.
We revealed that both proteins are expressed in the adhesive gland cells and that their distribution within the adhesive footprints was spatially restricted. RNA interference knockdown experiments demonstrated the essential function of these two proteins in flatworm …
We revealed that both proteins are expressed in the adhesive gland cells and that their distribution within the adhesive footprints was s …
Integrin-mediated activation of latent transforming growth factor beta.
Sheppard D. Sheppard D. Cancer Metastasis Rev. 2005 Sep;24(3):395-402. doi: 10.1007/s10555-005-5131-6. Cancer Metastasis Rev. 2005. PMID: 16258727 Review.
Members of the integrin family recognize a variety of spatially-restricted extracellular ligands. Classically, ligation of integrins activates cytoplasmic signals in the integrin-expressing cell and contributes to cell adhesion, migration, proliferation and s …
Members of the integrin family recognize a variety of spatially-restricted extracellular ligands. Classically, ligation of int …
The Ras-ERK pathway: understanding site-specific signaling provides hope of new anti-tumor therapies.
Calvo F, Agudo-Ibáñez L, Crespo P. Calvo F, et al. Bioessays. 2010 May;32(5):412-21. doi: 10.1002/bies.200900155. Bioessays. 2010. PMID: 20414899 Review.
Recent discoveries have suggested the concept that intracellular signals are the sum of multiple, site-specified subsignals, rather than single, homogeneous entities. ...These findings may open a gate for aiming at the Ras-ERK pathway in a spatially restri …
Recent discoveries have suggested the concept that intracellular signals are the sum of multiple, site-specified subsignals, r …
[Multiple sclerosis -- a channelopathy? Targeting ion channels and transporters in inflammatory neurodegeneration].
Meuth SG, Melzer N, Kleinschnitz C, Budde T, Wiendl H. Meuth SG, et al. Nervenarzt. 2009 Apr;80(4):422-9. doi: 10.1007/s00115-008-2599-7. Nervenarzt. 2009. PMID: 19011824 Review. German.
Third, redistribution of certain voltage- and ligand-gated ion channels and transporters along naked demyelinated axons restores axonal conduction but also leads to excessive spatially restricted electrical activity of the axonal membrane, intracellular calci …
Third, redistribution of certain voltage- and ligand-gated ion channels and transporters along naked demyelinated axons restores axonal cond …
mRNA localization: message on the move.
Jansen RP. Jansen RP. Nat Rev Mol Cell Biol. 2001 Apr;2(4):247-56. doi: 10.1038/35067016. Nat Rev Mol Cell Biol. 2001. PMID: 11283722 Review.
Cytoplasmic messenger RNA localization is a key post-transcriptional mechanism of establishing spatially restricted protein synthesis. The characterization of cis-acting signals within localized mRNAs, and the identification of trans-acting factors that recog …
Cytoplasmic messenger RNA localization is a key post-transcriptional mechanism of establishing spatially restricted protein sy …
Intracellular calcium signals display an avalanche-like behavior over multiple lengthscales.
Lopez L, Piegari E, Sigaut L, Ponce Dawson S. Lopez L, et al. Front Physiol. 2012 Sep 3;3:350. doi: 10.3389/fphys.2012.00350. eCollection 2012. Front Physiol. 2012. PMID: 22969730 Free PMC article.
Ca(2+) signals can either be spatially restricted (local) or propagate throughout the cell (global). ...In this paper we discuss these issues within the framework of simple models of Ca(2+) signal propagation. We also analyze the size distributi …
Ca(2+) signals can either be spatially restricted (local) or propagate throughout the cell (global). ...In this paper w …
CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.
Genau HM, Huber J, Baschieri F, Akutsu M, Dötsch V, Farhan H, Rogov V, Behrends C. Genau HM, et al. Mol Cell. 2015 Mar 19;57(6):995-1010. doi: 10.1016/j.molcel.2014.12.040. Epub 2015 Feb 12. Mol Cell. 2015. PMID: 25684205 Free article.
The small Rho GTPase RAC1 is an essential regulator of cellular signaling that controls actin rearrangements and cell motility. Here, we identify a novel CUL3 RING ubiquitin ligase complex, containing the substrate adaptors KBTBD6 and KBTBD7, that mediates ubiquitylation a …
The small Rho GTPase RAC1 is an essential regulator of cellular signaling that controls actin rearrangements and cell motility. Here, …
Possible role of epidermal keratinocytes in the construction of acupuncture meridians.
Denda M, Tsutsumi M. Denda M, et al. J Acupunct Meridian Stud. 2014 Apr;7(2):92-4. doi: 10.1016/j.jams.2013.03.002. Epub 2013 Apr 2. J Acupunct Meridian Stud. 2014. PMID: 24745868 Free article.
These sensory systems generate changes in the calcium-ion concentration in the epidermis, so epidermal keratinocytes can generate spatially-localized electro-physiological patterns in the skin. We have previously demonstrated signaling between epidermal keratinocyte …
These sensory systems generate changes in the calcium-ion concentration in the epidermis, so epidermal keratinocytes can generate spatial …
18 results