Modeling of spatially-restricted intracellular signaling.
Wiley Interdiscip Rev Syst Biol Med. 2012.
PMID: 21766466
Free PMC article.
Review.
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Modeling of spatially-restricted intracellular signaling.
Wiley Interdiscip Rev Syst Biol Med. 2012 Jan-Feb;4(1):103-15. doi: 10.1002/wsbm.155. Epub 2011 Jul 15.
Wiley Interdiscip Rev Syst Biol Med. 2012.
PMID: 21766466
Free PMC article.
Review.
Understanding the signaling capabilities of a cell presents a major challenge, not only due to the number of molecules involved, but also because of the complex network connectivity of intracellular signaling. Recently, the proliferation of quantitative imagi …
Understanding the signaling capabilities of a cell presents a major challenge, not only due to the number of molecules involved, but …
Models of spatially restricted biochemical reaction systems.
J Biol Chem. 2009 Feb 27;284(9):5445-9. doi: 10.1074/jbc.R800058200. Epub 2008 Oct 20.
J Biol Chem. 2009.
PMID: 18940805
Free PMC article.
Review.
Many reactions within the cell occur only in specific intracellular regions. Such local reaction networks give rise to microdomains of activated signaling components. ...The mathematical models show that, for membrane-initiated signaling, the ratio of …
Many reactions within the cell occur only in specific intracellular regions. Such local reaction networks give rise to microdomains o …
In vivo imaging of calcium dynamics in zebrafish hepatocytes.
Hepatology. 2023 Mar 1;77(3):789-801. doi: 10.1002/hep.32663. Epub 2023 Feb 17.
Hepatology. 2023.
PMID: 35829917
APPROACH AND RESULTS: We developed a transgenic model expressing a calcium sensor, GCaMP6s, specifically in zebrafish hepatocytes. Using this, we provide a quantitative assessment of intracellular calcium dynamics during multiple contexts, including growth, feeding, …
APPROACH AND RESULTS: We developed a transgenic model expressing a calcium sensor, GCaMP6s, specifically in zebrafish hepatocytes. Us …
A mechanism for temporary bioadhesion.
Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4297-4306. doi: 10.1073/pnas.1814230116. Epub 2019 Feb 19.
Proc Natl Acad Sci U S A. 2019.
PMID: 30782790
Free PMC article.
We revealed that both proteins are expressed in the adhesive gland cells and that their distribution within the adhesive footprints was spatially restricted. RNA interference knockdown experiments demonstrated the essential function of these two proteins in flatworm …
We revealed that both proteins are expressed in the adhesive gland cells and that their distribution within the adhesive footprints was s …
Control of Ca(2+) signals by astrocyte nanoscale morphology at tripartite synapses.
Glia. 2022 Dec;70(12):2378-2391. doi: 10.1002/glia.24258. Epub 2022 Sep 13.
Glia. 2022.
PMID: 36097958
Free PMC article.
Much of the Ca(2+) activity in astrocytes is spatially restricted to microdomains and occurs in fine processes that form a complex anatomical meshwork, the so-called spongiform domain. ...Simulations demonstrate that the nano-morphology of astrocytic processes power …
Much of the Ca(2+) activity in astrocytes is spatially restricted to microdomains and occurs in fine processes that form a com …
Integrin-mediated activation of latent transforming growth factor beta.
Cancer Metastasis Rev. 2005 Sep;24(3):395-402. doi: 10.1007/s10555-005-5131-6.
Cancer Metastasis Rev. 2005.
PMID: 16258727
Review.
Members of the integrin family recognize a variety of spatially-restricted extracellular ligands. Classically, ligation of integrins activates cytoplasmic signals in the integrin-expressing cell and contributes to cell adhesion, migration, proliferation and s …
Members of the integrin family recognize a variety of spatially-restricted extracellular ligands. Classically, ligation of int …
The Ras-ERK pathway: understanding site-specific signaling provides hope of new anti-tumor therapies.
Bioessays. 2010 May;32(5):412-21. doi: 10.1002/bies.200900155.
Bioessays. 2010.
PMID: 20414899
Review.
Recent discoveries have suggested the concept that intracellular signals are the sum of multiple, site-specified subsignals, rather than single, homogeneous entities. ...These findings may open a gate for aiming at the Ras-ERK pathway in a spatially restri …
Recent discoveries have suggested the concept that intracellular signals are the sum of multiple, site-specified subsignals, r …
Striatal mGlu(5)-mediated synaptic plasticity is independently regulated by location-specific receptor pools and divergent signaling pathways.
J Biol Chem. 2023 Aug;299(8):104949. doi: 10.1016/j.jbc.2023.104949. Epub 2023 Jun 22.
J Biol Chem. 2023.
PMID: 37354970
Free PMC article.
Recent work from this lab showed that mGlu(5) is one of a growing number of G protein-coupled receptors that can signal from intracellular membranes where it drives unique signaling pathways, including upregulation of extracellular signal-regulated kin …
Recent work from this lab showed that mGlu(5) is one of a growing number of G protein-coupled receptors that can signal from intra …
Probing microdomain Ca(2+) activity and synaptic transmission with a node-based tripartite synapse model.
Front Netw Physiol. 2023 Feb 10;3:1111306. doi: 10.3389/fnetp.2023.1111306. eCollection 2023.
Front Netw Physiol. 2023.
PMID: 36926546
Free PMC article.
Astrocytic fine processes are the most minor structures of astrocytes but host much of the Ca(2+) activity. These localized Ca(2+) signals spatially restricted to microdomains are crucial for information processing and synaptic transmission. ...To address the …
Astrocytic fine processes are the most minor structures of astrocytes but host much of the Ca(2+) activity. These localized Ca(2+) signal …
mRNA localization: message on the move.
Nat Rev Mol Cell Biol. 2001 Apr;2(4):247-56. doi: 10.1038/35067016.
Nat Rev Mol Cell Biol. 2001.
PMID: 11283722
Review.
Cytoplasmic messenger RNA localization is a key post-transcriptional mechanism of establishing spatially restricted protein synthesis. The characterization of cis-acting signals within localized mRNAs, and the identification of trans-acting factors that recog …
Cytoplasmic messenger RNA localization is a key post-transcriptional mechanism of establishing spatially restricted protein sy …
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