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Evidence for the expression of the EGF receptor on human monocytic cells.
Eales-Reynolds LJ, Laver H, Modjtahedi H. Eales-Reynolds LJ, et al. Cytokine. 2001 Dec 7;16(5):169-72. doi: 10.1006/cyto.2001.0966. Cytokine. 2001. PMID: 11814311
Immunotherapy of human tumour xenografts overexpressing the EGF receptor with rat antibodies that block growth factor-receptor interaction.
Modjtahedi H, Eccles S, Box G, Styles J, Dean C. Modjtahedi H, et al. Br J Cancer. 1993 Feb;67(2):254-61. doi: 10.1038/bjc.1993.49. Br J Cancer. 1993. PMID: 7679281 Free PMC article.
The antibodies, ICR16 (IgG2a), ICR62 (IgG2b) and ICR64 (IgG1), have been shown (Modjtahedi et al., 1993) to be potent inhibitors of the growth in vitro of a number of human squamous cell carcinomas because they block receptor-ligand interaction. ...
The antibodies, ICR16 (IgG2a), ICR62 (IgG2b) and ICR64 (IgG1), have been shown (Modjtahedi et al., 1993) to be potent inhibitors of t …
Immunotherapy with antibodies to the EGF receptor.
Dean C, Modjtahedi H, Eccles S, Box G, Styles J. Dean C, et al. Int J Cancer Suppl. 1994;8:103-7. doi: 10.1002/ijc.2910570722. Int J Cancer Suppl. 1994. PMID: 8194887
Phase I trial and tumour localisation of the anti-EGFR monoclonal antibody ICR62 in head and neck or lung cancer.
Modjtahedi H, Hickish T, Nicolson M, Moore J, Styles J, Eccles S, Jackson E, Salter J, Sloane J, Spencer L, Priest K, Smith I, Dean C, Gore M. Modjtahedi H, et al. Br J Cancer. 1996 Jan;73(2):228-35. doi: 10.1038/bjc.1996.40. Br J Cancer. 1996. PMID: 8546911 Free PMC article. Clinical Trial.
Antibody ICR62 could be detected at 4 h and 24 h in the sera of patients treated with 40 mg or 100 mg of ICR62. Only 4/20 patients showed HARA responses (one at 20 mg, one at 40 mg and two at 100 mg doses) and of these only the former two were anti-idiotypic respons …
Antibody ICR62 could be detected at 4 h and 24 h in the sera of patients treated with 40 mg or 100 mg of ICR62. Only 4/20 pati …
Monoclonal antibodies to the EGF receptor act as betacellulin antagonists.
Modjtahedi H, Dean C. Modjtahedi H, et al. Biochem Biophys Res Commun. 1996 Apr 25;221(3):625-30. doi: 10.1006/bbrc.1996.0646. Biochem Biophys Res Commun. 1996. PMID: 8630011
Anti-EGFR monoclonal antibodies which act as EGF, TGF alpha, HB-EGF and BTC antagonists block the binding of epiregulin to EGFR-expressing tumours.
Modjtahedi H, Komurasaki T, Toyoda H, Dean C. Modjtahedi H, et al. Int J Cancer. 1998 Jan 19;75(2):310-6. doi: 10.1002/(sici)1097-0215(19980119)75:2<310::aid-ijc22>3.0.co;2-f. Int J Cancer. 1998. PMID: 9462724
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