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Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease.
Kadyrov FA, Holmes SF, Arana ME, Lukianova OA, O'Donnell M, Kunkel TA, Modrich P. Kadyrov FA, et al. Among authors: modrich p. J Biol Chem. 2007 Dec 21;282(51):37181-90. doi: 10.1074/jbc.M707617200. Epub 2007 Oct 19. J Biol Chem. 2007. PMID: 17951253 Free PMC article.
Human MutLalpha (MLH1-PMS2 heterodimer) harbors a latent endonuclease that is dependent on the integrity of a PMS2 DQHA(X)2E(X)4E motif (Kadyrov, F. A., Dzantiev, L., Constantin, N., and Modrich, P. (2006) Cell 126, 297-308). This sequence element is conserved in ma …
Human MutLalpha (MLH1-PMS2 heterodimer) harbors a latent endonuclease that is dependent on the integrity of a PMS2 DQHA(X)2E(X)4E motif (Kad …
A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair.
Kadyrov FA, Genschel J, Fang Y, Penland E, Edelmann W, Modrich P. Kadyrov FA, et al. Among authors: modrich p. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8495-500. doi: 10.1073/pnas.0903654106. Epub 2009 May 6. Proc Natl Acad Sci U S A. 2009. PMID: 19420220 Free PMC article.
Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair.
Genschel J, Modrich P. Genschel J, et al. Among authors: modrich p. J Biol Chem. 2009 Aug 7;284(32):21536-44. doi: 10.1074/jbc.M109.021287. Epub 2009 Jun 10. J Biol Chem. 2009. PMID: 19515846 Free PMC article.
One model attributes the primary termination function in this system to RPA, with MutLalpha functioning in a secondary capacity by suppressing Exo1 hydrolysis of mismatch-free DNA (Genschel, J., and Modrich, P. (2003) Mol. Cell 12, 1077-1086). A second invokes MutLa …
One model attributes the primary termination function in this system to RPA, with MutLalpha functioning in a secondary capacity by suppressi …
180 results