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Modulation of endothelial cell migration and angiogenesis: a novel function for the "tandem-repeat" lectin galectin-8.
Delgado VM, Nugnes LG, Colombo LL, Troncoso MF, Fernández MM, Malchiodi EL, Frahm I, Croci DO, Compagno D, Rabinovich GA, Wolfenstein-Todel C, Elola MT. Delgado VM, et al. FASEB J. 2011 Jan;25(1):242-54. doi: 10.1096/fj.09-144907. Epub 2010 Sep 27. FASEB J. 2011. PMID: 20876211
Angiogenesis, the growth of new capillaries from preexisting blood vessels, is a complex process involving endothelial cell (EC) activation, disruption of vascular basement membranes, and migration and proliferation of ECs. ...Galectin-8
Angiogenesis, the growth of new capillaries from preexisting blood vessels, is a complex process involving endothelial cell
Galectin-8: a matricellular lectin with key roles in angiogenesis.
Troncoso MF, Ferragut F, Bacigalupo ML, Cárdenas Delgado VM, Nugnes LG, Gentilini L, Laderach D, Wolfenstein-Todel C, Compagno D, Rabinovich GA, Elola MT. Troncoso MF, et al. Glycobiology. 2014 Oct;24(10):907-14. doi: 10.1093/glycob/cwu054. Epub 2014 Jun 16. Glycobiology. 2014. PMID: 24939370 Review.
Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and
Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected
Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions.
Cueni LN, Detmar M. Cueni LN, et al. Exp Cell Res. 2009 Jun 10;315(10):1715-23. doi: 10.1016/j.yexcr.2009.02.021. Epub 2009 Mar 4. Exp Cell Res. 2009. PMID: 19268462 Free PMC article.
Here we show that, similar to podoplanin, galectin-8 is more highly expressed by lymphatic than by blood vascular endothelial cells, and that it promotes lymphatic endothelial cell adhesion as well as haptotactic migration when imm …
Here we show that, similar to podoplanin, galectin-8 is more highly expressed by lymphatic than by blood vascular endotheli