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The reverse transcriptase-RNase H: from viruses to antiviral defense.
Moelling K, Broecker F. Moelling K, et al. Ann N Y Acad Sci. 2015 Apr;1341:126-35. doi: 10.1111/nyas.12668. Epub 2015 Feb 19. Ann N Y Acad Sci. 2015. PMID: 25703292 Review.
RNase H: specificity, mechanisms of action, and antiviral target.
Moelling K, Broecker F, Kerrigan JE. Moelling K, et al. Methods Mol Biol. 2014;1087:71-84. doi: 10.1007/978-1-62703-670-2_7. Methods Mol Biol. 2014. PMID: 24158815
Premature activation of the HIV RNase H drives the virus into suicide: a novel microbicide?
Broecker F, Andrae K, Moelling K. Broecker F, et al. Among authors: moelling k. AIDS Res Hum Retroviruses. 2012 Nov;28(11):1397-403. doi: 10.1089/aid.2012.0067. Epub 2012 Aug 29. AIDS Res Hum Retroviruses. 2012. PMID: 22931114 Review.
Targeting the retroviral ribonuclease H by rational drug design.
Moelling K. Moelling K. AIDS. 2012 Oct 23;26(16):1983-93. doi: 10.1097/QAD.0b013e32835537d3. AIDS. 2012. PMID: 22555171 Review.
A short hairpin loop-structured oligodeoxynucleotide targeting the virion-associated RNase H of HIV inhibits HIV production in cell culture and in huPBL-SCID mice.
Heinrich J, Schols D, Moelling K. Heinrich J, et al. Among authors: moelling k. Intervirology. 2012;55(3):242-6. doi: 10.1159/000324544. Epub 2011 May 17. Intervirology. 2012. PMID: 21576910
Vero cells as a model to study the effects of adenoviral gene delivery vectors on the RNAi system in context of viral infection.
Matskevich AA, Jung JS, Schümann M, Cascallo M, Moelling K. Matskevich AA, et al. Among authors: moelling k. J Innate Immun. 2009;1(4):389-94. doi: 10.1159/000191408. Epub 2009 Jan 8. J Innate Immun. 2009. PMID: 20375596
Reduction of gene expression by a hairpin-loop structured oligodeoxynucleotide: alternative to siRNA and antisense.
Kwok T, Heinrich J, Jung-Shiu J, Meier MG, Mathur S, Moelling K. Kwok T, et al. Among authors: moelling k. Biochim Biophys Acta. 2009 Oct;1790(10):1170-8. doi: 10.1016/j.bbagen.2009.05.017. Epub 2009 Jun 6. Biochim Biophys Acta. 2009. PMID: 19505533
RNase H-mediated retrovirus destruction in vivo triggered by oligodeoxynucleotides.
Matzen K, Elzaouk L, Matskevich AA, Nitzsche A, Heinrich J, Moelling K. Matzen K, et al. Among authors: moelling k. Nat Biotechnol. 2007 Jun;25(6):669-74. doi: 10.1038/nbt1311. Epub 2007 Jun 3. Nat Biotechnol. 2007. PMID: 17546028
Short partially double-stranded oligodeoxynucleotide induces reverse transcriptase/RNase H-mediated cleavage of HIV RNA and contributes to abrogation of infectivity of virions.
Matskevich AA, Ziogas A, Heinrich J, Quast SA, Moelling K. Matskevich AA, et al. Among authors: moelling k. AIDS Res Hum Retroviruses. 2006 Dec;22(12):1220-30. doi: 10.1089/aid.2006.22.1220. AIDS Res Hum Retroviruses. 2006. PMID: 17209763
Oligonucleotide-mediated retroviral RNase H activation leads to reduced HIV-1 titer in patient-derived plasma.
Heinrich J, Mathur S, Matskevich AA, Moelling K. Heinrich J, et al. Among authors: moelling k. AIDS. 2009 Jan 14;23(2):213-21. doi: 10.1097/QAD.0b013e32831c5480. AIDS. 2009. PMID: 19098491
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