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Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity.
Moghaddam A, Bicknell R. Moghaddam A, et al. Biochemistry. 1992 Dec 8;31(48):12141-6. doi: 10.1021/bi00163a024. Biochemistry. 1992. PMID: 1457409
Platelet-derived endothelial cell growth factor (PD-ECGF) has been expressed in Escherichia coli as a fusion protein with glutathione S-transferase (GST). ...Recombinant PD-ECGF stimulated [3H]methylthymidine uptake by endothelial cells in vitro; however, we were unable to …
Platelet-derived endothelial cell growth factor (PD-ECGF) has been expressed in Escherichia coli as a fusion protein with glutathione …
Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis.
Relf M, LeJeune S, Scott PA, Fox S, Smith K, Leek R, Moghaddam A, Whitehouse R, Bicknell R, Harris AL. Relf M, et al. Among authors: moghaddam a. Cancer Res. 1997 Mar 1;57(5):963-9. Cancer Res. 1997. PMID: 9041202
Angiogenesis is a significant prognostic factor in breast cancer, but the factors that control angiogenesis in vivo are not well defined. ...Inhibiting endothelial migration or agents directly toxic to endothelium would be of value in a combined approach to therapy. …
Angiogenesis is a significant prognostic factor in breast cancer, but the factors that control angiogenesis in vivo are not well defi …
Expression of the angiogenic factor thymidine phosphorylase/platelet-derived endothelial cell growth factor in primary bladder cancers.
O'Brien TS, Fox SB, Dickinson AJ, Turley H, Westwood M, Moghaddam A, Gatter KC, Bicknell R, Harris AL. O'Brien TS, et al. Among authors: moghaddam a. Cancer Res. 1996 Oct 15;56(20):4799-804. Cancer Res. 1996. PMID: 8841001
To examine its role more clearly, we have quantified and localized its expression using Western analysis and immunohistochemistry in a series of 105 bladder cancers. ...Because TP can activate a number of cytotoxic agents, it provides a potential therapeutic …
To examine its role more clearly, we have quantified and localized its expression using Western analysis and immunohistochemistry in a
Breast cancer angiogenesis--new approaches to therapy via antiangiogenesis, hypoxic activated drugs, and vascular targeting.
Harris AL, Zhang H, Moghaddam A, Fox S, Scott P, Pattison A, Gatter K, Stratford I, Bicknell R. Harris AL, et al. Among authors: moghaddam a. Breast Cancer Res Treat. 1996;38(1):97-108. doi: 10.1007/BF01803788. Breast Cancer Res Treat. 1996. PMID: 8825127 Review.
Inhibiting angiogenesis by blocking vascular growth factors would be difficult with highly specific agents, but drugs with a broader spectrum of antagonism may be effective. ...The prognostic importance of angiogenesis suggests that this should be a major new therap …
Inhibiting angiogenesis by blocking vascular growth factors would be difficult with highly specific agents, but drugs with a broader …
Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study.
Fox SB, Moghaddam A, Westwood M, Turley H, Bicknell R, Gatter KC, Harris AL. Fox SB, et al. Among authors: moghaddam a. J Pathol. 1995 Jun;176(2):183-90. doi: 10.1002/path.1711760212. J Pathol. 1995. PMID: 7636628
It is a complex multi-step process controlled by a number of angiogenic factors. One such factor is platelet-derived endothelial cell growth factor (PD-ECGF), recently shown to be thymidine phosphorylase (TP), which is angiogenic in several in vivo assays and tumour …
It is a complex multi-step process controlled by a number of angiogenic factors. One such factor is platelet-derived endotheli …
Thymidine phosphorylase is angiogenic and promotes tumor growth.
Moghaddam A, Zhang HT, Fan TP, Hu DE, Lees VC, Turley H, Fox SB, Gatter KC, Harris AL, Bicknell R. Moghaddam A, et al. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):998-1002. doi: 10.1073/pnas.92.4.998. Proc Natl Acad Sci U S A. 1995. PMID: 7532308 Free PMC article.
Despite this, TP is strongly angiogenic in a rat sponge and freeze-injured skin graft model. Neutralizing antibodies and site-directed mutagenesis confirmed that the enzyme activity of TP is a condition for its angiogenic activity. ...These data and the correlation …
Despite this, TP is strongly angiogenic in a rat sponge and freeze-injured skin graft model. Neutralizing antibodies and site-directe …
Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase.
Patterson AV, Zhang H, Moghaddam A, Bicknell R, Talbot DC, Stratford IJ, Harris AL. Patterson AV, et al. Among authors: moghaddam a. Br J Cancer. 1995 Sep;72(3):669-75. doi: 10.1038/bjc.1995.392. Br J Cancer. 1995. PMID: 7669579 Free PMC article.
The human MCF-7 breast cancer cell line was transfected with the dThdPase cDNA and expressed a 45 kDa protein that was detected with anti-dThdPase antibody. ...These results confirm that dThdPase is a major pathway in the metabolic activation of 5'-DFUR, and the bys …
The human MCF-7 breast cancer cell line was transfected with the dThdPase cDNA and expressed a 45 kDa protein that was detected with …
The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase is up-regulated in breast cancer epithelium and endothelium.
Fox SB, Westwood M, Moghaddam A, Comley M, Turley H, Whitehouse RM, Bicknell R, Gatter KC, Harris AL. Fox SB, et al. Among authors: moghaddam a. Br J Cancer. 1996 Feb;73(3):275-80. doi: 10.1038/bjc.1996.49. Br J Cancer. 1996. PMID: 8562330 Free PMC article.
Tumour angiogenesis is a complex multistep process regulated by a number of angiogenic factors. One such factor, platelet-derived endothelial cell growth factor has recently been shown to be thymidine phosphorylase (TP). ...Therefore, this enzyme might be a p …
Tumour angiogenesis is a complex multistep process regulated by a number of angiogenic factors. One such factor, platelet-deri …
Association of ovarian malignancy with expression of platelet-derived endothelial cell growth factor.
Reynolds K, Farzaneh F, Collins WP, Campbell S, Bourne TH, Lawton F, Moghaddam A, Harris AL, Bicknell R. Reynolds K, et al. Among authors: moghaddam a. J Natl Cancer Inst. 1994 Aug 17;86(16):1234-8. doi: 10.1093/jnci/86.16.1234. J Natl Cancer Inst. 1994. PMID: 7518876
., the velocity was > 7 cm/s) and, together with a pulsatile index of less than 1.0, constituted a positive scanning result. ...A ribonuclease protection assay was used to assess the expression of mRNA coding for the four angiogenic factors. RESULTS: Two n …
., the velocity was > 7 cm/s) and, together with a pulsatile index of less than 1.0, constituted a positive scanning result …
Expression of a novel factor, com1, is regulated by 1,25-dihydroxyvitamin D3 in breast cancer cells.
Bratland A, Risberg K, Maelandsmo GM, Gützkow KB, Olsen OE, Moghaddam A, Wang MY, Hansen CM, Blomhoff HK, Berg JP, Fodstad O, Ree AH. Bratland A, et al. Among authors: moghaddam a. Cancer Res. 2000 Oct 1;60(19):5578-83. Cancer Res. 2000. PMID: 11034106
Tumor cells and their surrounding microenvironment produce a variety of factors that promote tumor growth and metastasis. We recently identified a nuclear factor, termed com1, that is up-regulated in human breast carcinoma cells on formation of experimental metastat …
Tumor cells and their surrounding microenvironment produce a variety of factors that promote tumor growth and metastasis. We recently …
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