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CXCR4 and cancer.
Furusato B, Mohamed A, Uhlén M, Rhim JS. Furusato B, et al. Pathol Int. 2010 Jul;60(7):497-505. doi: 10.1111/j.1440-1827.2010.02548.x. Pathol Int. 2010. PMID: 20594270 Review.
The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors and has been identified to play a crucial role in a number of biological processes, including the trafficking and homeostasis of immune cells such as T lymphocytes. ...The C …
The chemokine receptor CXCR4 belongs to the large superfamily of G protein-coupled receptors and has been identified to play a crucia …
Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-Positive Prostate Cancer Cells.
Mohamed AA, Tan SH, Xavier CP, Katta S, Huang W, Ravindranath L, Jamal M, Li H, Srivastava M, Srivatsan ES, Sreenath TL, McLeod DG, Srinivasan A, Petrovics G, Dobi A, Srivastava S. Mohamed AA, et al. Mol Cancer Res. 2017 Oct;15(10):1308-1317. doi: 10.1158/1541-7786.MCR-17-0058. Epub 2017 Jun 12. Mol Cancer Res. 2017. PMID: 28607007 Free PMC article.
Analytical platform evaluation for quantification of ERG in prostate cancer using protein and mRNA detection methods.
He J, Schepmoes AA, Shi T, Wu C, Fillmore TL, Gao Y, Smith RD, Qian WJ, Rodland KD, Liu T, Camp DG 2nd, Rastogi A, Tan SH, Yan W, Mohamed AA, Huang W, Banerjee S, Kagan J, Srivastava S, McLeod DG, Srivastava S, Petrovics G, Dobi A, Srinivasan A. He J, et al. J Transl Med. 2015 Feb 12;13:54. doi: 10.1186/s12967-015-0418-z. J Transl Med. 2015. PMID: 25889691 Free PMC article.
The sensitivity of the PRISM-SRM assay was approximately 10,000 VCaP cells in a mixed cell population model of VCaP and LNCaP cells. ...On the other hand, qRT-PCR exhibited a higher sensitivity, as TMPRSS2-ERG transcripts were detected in as few as 100 VCaP cells, i …
The sensitivity of the PRISM-SRM assay was approximately 10,000 VCaP cells in a mixed cell population model of VCaP and LNCaP cells. …
Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN.
Li H, Mohamed AA, Sharad S, Umeda E, Song Y, Young D, Petrovics G, McLeod DG, Sesterhenn IA, Sreenath T, Dobi A, Srivastava S. Li H, et al. Oncotarget. 2015 Jun 20;6(17):15137-49. doi: 10.18632/oncotarget.3526. Oncotarget. 2015. PMID: 25883222 Free PMC article.
Androgen Receptor (AR) is the male hormone receptor and a nuclear transcription factor which plays a central role in the growth of normal and malignant prostate gland. ...In a subset of human CaP, decreased PMEPA1 mRNA expression significantly correlated with …
Androgen Receptor (AR) is the male hormone receptor and a nuclear transcription factor which plays a central role in the growt …
ERG oncoprotein inhibits ANXA2 expression and function in prostate cancer.
Griner NB, Young D, Chaudhary P, Mohamed AA, Huang W, Chen Y, Sreenath T, Dobi A, Petrovics G, Vishwanatha JK, Sesterhenn IA, Srivastava S, Tan SH. Griner NB, et al. Mol Cancer Res. 2015 Feb;13(2):368-79. doi: 10.1158/1541-7786.MCR-14-0275-T. Epub 2014 Oct 24. Mol Cancer Res. 2015. PMID: 25344575 Free PMC article.
ANXA2, a Ca(2+)-dependent and phospholipid-binding protein, is involved in various cellular functions, including maintenance of epithelial cell polarity. ...Immunohistochemistry demonstrated a reciprocal relationship of ANXA2 and ERG expression in a large fra …
ANXA2, a Ca(2+)-dependent and phospholipid-binding protein, is involved in various cellular functions, including maintenance of epith …
Functional antagonism of TMPRSS2-ERG splice variants in prostate cancer.
Rastogi A, Tan SH, Mohamed AA, Chen Y, Hu Y, Petrovics G, Sreenath T, Kagan J, Srivastava S, McLeod DG, Sesterhenn IA, Srivastava S, Dobi A, Srinivasan A. Rastogi A, et al. Genes Cancer. 2014 Jul;5(7-8):273-84. doi: 10.18632/genesandcancer.25. Genes Cancer. 2014. PMID: 25221645 Free PMC article.
Expression of exogenous ERG8 protein resulted in a decrease in endogenous ERG3 protein levels in TMPRSS2-ERG positive VCaP cells, with a concomitant decrease in C-MYC. Further, we showed a physical association between ERG3 and ERG8 in live cells by the bimole …
Expression of exogenous ERG8 protein resulted in a decrease in endogenous ERG3 protein levels in TMPRSS2-ERG positive VCaP cells, wit …
Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer.
Thangapazham R, Saenz F, Katta S, Mohamed AA, Tan SH, Petrovics G, Srivastava S, Dobi A. Thangapazham R, et al. BMC Cancer. 2014 Jan 13;14:16. doi: 10.1186/1471-2407-14-16. BMC Cancer. 2014. PMID: 24418414 Free PMC article.
BACKGROUND: In normal prostate epithelium the TMPRSS2 gene encoding a type II serine protease is directly regulated by male hormones through the androgen receptor. ...
BACKGROUND: In normal prostate epithelium the TMPRSS2 gene encoding a type II serine protease is directly regulated by male hormones …
Evaluation of ERG responsive proteome in prostate cancer.
Tan SH, Furusato B, Fang X, He F, Mohamed AA, Griner NB, Sood K, Saxena S, Katta S, Young D, Chen Y, Sreenath T, Petrovics G, Dobi A, McLeod DG, Sesterhenn IA, Saxena S, Srivastava S. Tan SH, et al. Prostate. 2014 Jan;74(1):70-89. doi: 10.1002/pros.22731. Epub 2013 Sep 21. Prostate. 2014. PMID: 24115221 Free PMC article.
BACKGROUND: Gene fusion between TMPRSS2 promoter and the ERG proto-oncogene is a major genomic alteration found in over half of prostate cancers (CaP), which leads to aberrant androgen dependent ERG expression. ...Meta-analysis of ERPs against CaP gene expression data reve …
BACKGROUND: Gene fusion between TMPRSS2 promoter and the ERG proto-oncogene is a major genomic alteration found in over half of prost …
Ets family protein, erg expression in developing and adult mouse tissues by a highly specific monoclonal antibody.
Mohamed AA, Tan SH, Mikhalkevich N, Ponniah S, Vasioukhin V, Bieberich CJ, Sesterhenn IA, Dobi A, Srivastava S, Sreenath TL. Mohamed AA, et al. J Cancer. 2010 Oct 25;1:197-208. doi: 10.7150/jca.1.197. J Cancer. 2010. PMID: 21060730 Free PMC article.
Here, we analyzed temporal and spatial expression of the Erg (mouse protein) by immunohistochemical analysis during mouse embryonic and adult organogenesis using a highly specific ERG monoclonal antibody (ERG MAb). ...Intriguingly, Erg is not expressed in any epithelial ti …
Here, we analyzed temporal and spatial expression of the Erg (mouse protein) by immunohistochemical analysis during mouse embryonic and adul …
ERG oncogene modulates prostaglandin signaling in prostate cancer cells.
Mohamed AA, Tan SH, Sun C, Shaheduzzaman S, Hu Y, Petrovics G, Chen Y, Sesterhenn IA, Li H, Sreenath T, McLeod DG, Dobi A, Srivastava S. Mohamed AA, et al. Cancer Biol Ther. 2011 Feb 15;11(4):410-7. doi: 10.4161/cbt.11.4.14180. Epub 2011 Feb 15. Cancer Biol Ther. 2011. PMID: 21178489 Free PMC article.
This study suggests that ERG activation plays a role in prostaglandin signaling because knockdown of ERG expression in TMPRSS2-ERG fusion containing CaP cells leads to altered levels of the 15-hydroxy-prostaglandin dehydrogenase (HPGD), a tumor suppressor and prosta …
This study suggests that ERG activation plays a role in prostaglandin signaling because knockdown of ERG expression in TMPRSS2-ERG fu …
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