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Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles.
Denisov AY, Chen G, Sprules T, Moldoveanu T, Beauparlant P, Gehring K. Denisov AY, et al. Among authors: moldoveanu t. Biochemistry. 2006 Feb 21;45(7):2250-6. doi: 10.1021/bi052332s. Biochemistry. 2006. PMID: 16475813
BID-induced structural changes in BAK promote apoptosis.
Moldoveanu T, Grace CR, Llambi F, Nourse A, Fitzgerald P, Gehring K, Kriwacki RW, Green DR. Moldoveanu T, et al. Nat Struct Mol Biol. 2013 May;20(5):589-97. doi: 10.1038/nsmb.2563. Epub 2013 Apr 21. Nat Struct Mol Biol. 2013. PMID: 23604079 Free PMC article.
A unified model of mammalian BCL-2 protein family interactions at the mitochondria.
Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL, Dillon CP, Green DR. Llambi F, et al. Among authors: moldoveanu t. Mol Cell. 2011 Nov 18;44(4):517-31. doi: 10.1016/j.molcel.2011.10.001. Epub 2011 Oct 27. Mol Cell. 2011. PMID: 22036586 Free PMC article.
Apoptotic regulation by MCL-1 through heterodimerization.
Liu Q, Moldoveanu T, Sprules T, Matta-Camacho E, Mansur-Azzam N, Gehring K. Liu Q, et al. Among authors: moldoveanu t. J Biol Chem. 2010 Jun 18;285(25):19615-24. doi: 10.1074/jbc.M110.105452. Epub 2010 Apr 14. J Biol Chem. 2010. PMID: 20392693 Free PMC article.
Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase.
Kozlov G, Peschard P, Zimmerman B, Lin T, Moldoveanu T, Mansur-Azzam N, Gehring K, Park M. Kozlov G, et al. Among authors: moldoveanu t. J Biol Chem. 2007 Sep 14;282(37):27547-55. doi: 10.1074/jbc.M703333200. Epub 2007 Jul 16. J Biol Chem. 2007. PMID: 17635922
The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site.
Moldoveanu T, Liu Q, Tocilj A, Watson M, Shore G, Gehring K. Moldoveanu T, et al. Mol Cell. 2006 Dec 8;24(5):677-688. doi: 10.1016/j.molcel.2006.10.014. Mol Cell. 2006. PMID: 17157251
Calpain inhibition by alpha-ketoamide and cyclic hemiacetal inhibitors revealed by X-ray crystallography.
Cuerrier D, Moldoveanu T, Inoue J, Davies PL, Campbell RL. Cuerrier D, et al. Among authors: moldoveanu t. Biochemistry. 2006 Jun 20;45(24):7446-52. doi: 10.1021/bi060425j. Biochemistry. 2006. PMID: 16768440
BH3 domains other than Bim and Bid can directly activate Bax/Bak.
Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T. Du H, et al. Among authors: moldoveanu t. J Biol Chem. 2011 Jan 7;286(1):491-501. doi: 10.1074/jbc.M110.167148. Epub 2010 Nov 1. J Biol Chem. 2011. PMID: 21041309 Free PMC article.
Many players in BCL-2 family affairs.
Moldoveanu T, Follis AV, Kriwacki RW, Green DR. Moldoveanu T, et al. Trends Biochem Sci. 2014 Mar;39(3):101-11. doi: 10.1016/j.tibs.2013.12.006. Epub 2014 Feb 3. Trends Biochem Sci. 2014. PMID: 24503222 Free PMC article. Review.
Methods to Probe Conformational Activation and Mitochondrial Activity of Proapoptotic BAK.
Singh G, Moldoveanu T. Singh G, et al. Among authors: moldoveanu t. Methods Mol Biol. 2019;1877:185-200. doi: 10.1007/978-1-4939-8861-7_13. Methods Mol Biol. 2019. PMID: 30536007
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