Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 1
2013 2
2014 1
2015 1
2019 1
2021 1
2024 1
2025 4

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

11 results

Results by year

Citations

2 articles found by citation matching
Show all

Search results

Filters applied: . Clear all
Page 1
Molecular basis of proton-sensing by G protein-coupled receptors.
Howard MK, Hoppe N, Huang XP, Macdonald CB, Mehrota E, Grimes PR, Zahm A, Trinidad DD, English J, Coyote-Maestas W, Manglik A. Howard MK, et al. bioRxiv [Preprint]. 2024 Apr 18:2024.04.17.590000. doi: 10.1101/2024.04.17.590000. bioRxiv. 2024. Update in: Cell. 2025 Feb 06;188(3):671-687.e20. doi: 10.1016/j.cell.2024.11.036. PMID: 38659943 Free PMC article. Updated. Preprint.
Three proton-sensing G protein-coupled receptors (GPCRs), GPR4, GPR65, and GPR68, respond to changes in extracellular pH to regulate diverse physiology and are implicated in a wide range of diseases. A central challenge in determining how …
Three proton-sensing G protein-coupled receptors (GPCRs), GPR4, GPR65, and GPR68, respond to chang …
Molecular basis of proton sensing by G protein-coupled receptors.
Howard MK, Hoppe N, Huang XP, Mitrovic D, Billesbølle CB, Macdonald CB, Mehrotra E, Rockefeller Grimes P, Trinidad DD, Delemotte L, English JG, Coyote-Maestas W, Manglik A. Howard MK, et al. Cell. 2025 Feb 6;188(3):671-687.e20. doi: 10.1016/j.cell.2024.11.036. Epub 2025 Jan 2. Cell. 2025. PMID: 39753132
Three proton-sensing G protein-coupled receptors (GPCRs)-GPR4, GPR65, and GPR68-respond to extracellular pH to regulate diverse physiology. How protons activate these receptors is poorly understood. We determined cryogenic-e …
Three proton-sensing G protein-coupled receptors (GPCRs)-GPR4, GPR65, and GPR68-respond to extrace …
Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4.
Wen X, Shang P, Chen H, Guo L, Rong N, Jiang X, Li X, Liu J, Yang G, Zhang J, Zhu K, Meng Q, He X, Wang Z, Liu Z, Cheng H, Zheng Y, Zhang B, Pang J, Liu Z, Xiao P, Chen Y, Liu L, Luo F, Yu X, Yi F, Zhang P, Yang F, Deng C, Sun JP. Wen X, et al. Cell. 2025 Feb 6;188(3):653-670.e24. doi: 10.1016/j.cell.2024.12.001. Epub 2025 Jan 2. Cell. 2025. PMID: 39753131
Animals have evolved pH-sensing membrane receptors, such as G-protein-coupled receptor 4 (GPR4), to monitor pH changes related to their physiology and generate adaptive reactions. ...Overall, our study revealed common and distinct mechanisms of …
Animals have evolved pH-sensing membrane receptors, such as G-protein-coupled receptor 4 (GPR4), to monit …
Chemogenic Subqualities of Mouthfeel.
Simons CT, Klein AH, Carstens E. Simons CT, et al. Chem Senses. 2019 May 29;44(5):281-288. doi: 10.1093/chemse/bjz016. Chem Senses. 2019. PMID: 31039245 Free PMC article. Review.
The molecular profile of these channels and receptors involved in mouthfeel include many transient receptor potential channels, proton-sensitive ion channels, and potassium channels to name a few. During the last several years, studies using molecular …
The molecular profile of these channels and receptors involved in mouthfeel include many transient receptor potential channels …
Structural basis of stepwise proton sensing-mediated GPCR activation.
Yue X, Peng L, Liu S, Zhang B, Zhang X, Chang H, Pei Y, Li X, Liu J, Shui W, Wu L, Xu H, Liu ZJ, Hua T. Yue X, et al. Cell Res. 2025 Jun;35(6):423-436. doi: 10.1038/s41422-025-01092-w. Epub 2025 Apr 11. Cell Res. 2025. PMID: 40211064 Free PMC article.
The regulation of pH homeostasis is crucial in many biological processes vital for survival, growth, and function of life. The pH-sensing G protein-coupled receptors (GPCRs), including GPR4, GPR65 and GPR68, play a pivotal role in detecting chan …
The regulation of pH homeostasis is crucial in many biological processes vital for survival, growth, and function of life. The pH-sensing …
Structural basis and biased signaling of proton sensation by GPCRs mediated by extracellular histidine rearrangement.
Guo L, Zhu K, Zhong YN, Gao M, Liu J, Qi Z, Liu Z, Rong N, Zhang M, Li D, Zhang Q, Yang G, Zhang X, Zhang M, Ding N, Ping YQ, Yang Z, Xiao P, Xia M, Yu X, Gaole A, Sun JP, Yang F. Guo L, et al. Mol Cell. 2025 Apr 17;85(8):1658-1673.e7. doi: 10.1016/j.molcel.2025.03.018. Epub 2025 Apr 10. Mol Cell. 2025. PMID: 40215959
Proton sensing by G protein-coupled receptors (GPCRs) is crucial in many life activities. ...Collectively, we provide structural insights into the proton sensing, activation, and downstream effector coupling mechanisms of …
Proton sensing by G protein-coupled receptors (GPCRs) is crucial in many life activities. ...Colle …
The biophysical and molecular basis of intracellular pH sensing by Na+/H+ exchanger-3.
Babich V, Vadnagara K, Di Sole F. Babich V, et al. FASEB J. 2013 Nov;27(11):4646-58. doi: 10.1096/fj.12-225466. Epub 2013 Aug 9. FASEB J. 2013. PMID: 23934281 Free PMC article.
This effect presupposes an intracellular pH (pHi) dependence of NHE3 activity, although the biophysical and molecular basis of NHE3 pHi sensitivity have not been defined. NHE3, when complexed with the calcineurin homologous protein-1 (CHP1), had a shift in pHi sensi …
This effect presupposes an intracellular pH (pHi) dependence of NHE3 activity, although the biophysical and molecular basis of …
Gastric acid, calcium absorption, and their impact on bone health.
Kopic S, Geibel JP. Kopic S, et al. Physiol Rev. 2013 Jan;93(1):189-268. doi: 10.1152/physrev.00015.2012. Physiol Rev. 2013. PMID: 23303909 Free article. Review.
This article reviews the physiology of gastric acid secretion, intestinal calcium absorption, and their respective neuroendocrine regulation and explores the physiological basis of a potential link between these individual systems....
This article reviews the physiology of gastric acid secretion, intestinal calcium absorption, and their respective neuroendocrine regulation …
Architectural and functional similarities between trimeric ATP-gated P2X receptors and acid-sensing ion channels.
Kellenberger S, Grutter T. Kellenberger S, et al. J Mol Biol. 2015 Jan 16;427(1):54-66. doi: 10.1016/j.jmb.2014.06.004. Epub 2014 Jun 14. J Mol Biol. 2015. PMID: 24937752 Free article. Review.
ATP-gated P2X receptors and acid-sensing ion channels are two distinct ligand-gated ion channels that assemble into trimers. ...However, the recent determination of their molecular structures by X-ray crystallography has revealed unexpected parallels in the a …
ATP-gated P2X receptors and acid-sensing ion channels are two distinct ligand-gated ion channels that assemble into trimers. . …
TAT Rhodopsin Is an Ultraviolet-Dependent Environmental pH Sensor.
Kataoka C, Sugimoto T, Shigemura S, Katayama K, Tsunoda SP, Inoue K, Béjà O, Kandori H. Kataoka C, et al. Biochemistry. 2021 Mar 30;60(12):899-907. doi: 10.1021/acs.biochem.0c00951. Epub 2021 Mar 15. Biochemistry. 2021. PMID: 33721993 Free article.
In many rhodopsins, the retinal Schiff base pK(a) remains very high, ensuring Schiff base protonation captures visible light. Nevertheless, recently we found that TAT rhodopsin contains protonated and unprotonated forms at physiological pH. ...Here we studied the …
In many rhodopsins, the retinal Schiff base pK(a) remains very high, ensuring Schiff base protonation captures visible light. Neverth …
11 results