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Molecular Features of Phosphatase and Tensin Homolog (PTEN) Regulation by C-terminal Phosphorylation.
Chen Z, Dempsey DR, Thomas SN, Hayward D, Bolduc DM, Cole PA. Chen Z, et al. J Biol Chem. 2016 Jul 1;291(27):14160-14169. doi: 10.1074/jbc.M116.728980. Epub 2016 May 11. J Biol Chem. 2016. PMID: 27226612 Free PMC article.
PTEN is a tumor suppressor that functions to negatively regulate the PI3K/AKT pathway as the lipid phosphatase for phosphatidylinositol 3,4,5-triphosphate. ...To further the structural understanding of PTEN regulation by C-terminal
PTEN is a tumor suppressor that functions to negatively regulate the PI3K/AKT pathway as the lipid phosphatase for phos
PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer.
Malaney P, Palumbo E, Semidey-Hurtado J, Hardee J, Stanford K, Kathiriya JJ, Patel D, Tian Z, Allen-Gipson D, Davé V. Malaney P, et al. Cell Cycle. 2018;17(8):947-962. doi: 10.1080/15384101.2017.1388970. Epub 2018 May 31. Cell Cycle. 2018. PMID: 29108454 Free PMC article.
PTEN phosphorylation at its C-terminal (C-tail) serine/threonine cluster negatively regulates its tumor suppressor function. ...Abbreviations AKT V-Akt Murine Thymoma Viral Oncogene CA Cancer adjacent CDK1 Cyclin dependent kinase 1 CENPC-
PTEN phosphorylation at its C-terminal (C-tail) serine/threonine cluster negatively regulates its
The structural basis of PTEN regulation by multi-site phosphorylation.
Dempsey DR, Viennet T, Iwase R, Park E, Henriquez S, Chen Z, Jeliazkov JR, Palanski BA, Phan KL, Coote P, Gray JJ, Eck MJ, Gabelli SB, Arthanari H, Cole PA. Dempsey DR, et al. Nat Struct Mol Biol. 2021 Oct;28(10):858-868. doi: 10.1038/s41594-021-00668-5. Epub 2021 Oct 8. Nat Struct Mol Biol. 2021. PMID: 34625746
Phosphatase and tensin homolog (PTEN) is a phosphatidylinositol-3,4,5-triphosphate (PIP(3)) phospholipid phosphatase that is commonly mutated or silenced in cancer. PTEN's catalytic activity, cellular membrane localization and stab
Phosphatase and tensin homolog (PTEN) is a phosphatidylinositol-3,4,5-triphosphate (PIP(3)) phospholipid phos
Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes.
González-Sánchez A, Jaraíz-Rodríguez M, Domínguez-Prieto M, Herrero-González S, Medina JM, Tabernero A. González-Sánchez A, et al. Oncotarget. 2016 Aug 2;7(31):49819-49833. doi: 10.18632/oncotarget.10454. Oncotarget. 2016. PMID: 27391443 Free PMC article.
In this work we aimed to investigate the mechanism responsible for this effect. The inhibition of c-Src requires phosphorylation at tyrosine 527 mediated by C-terminal Src kinase (Csk) and dephosphorylation at tyrosine 416 mediated by phosphatases
In this work we aimed to investigate the mechanism responsible for this effect. The inhibition of c-Src requires phosphorylation
Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.
Leslie NR, Bennett D, Gray A, Pass I, Hoang-Xuan K, Downes CP. Leslie NR, et al. Biochem J. 2001 Jul 15;357(Pt 2):427-35. doi: 10.1042/0264-6021:3570427. Biochem J. 2001. PMID: 11439092 Free PMC article.
The tumour suppressor protein PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a lipid phosphatase which can antagonize the phosphoinositide 3-kinase (PI 3-kinase) signalling pathway, promoting apoptosis and inhibiting ce …
The tumour suppressor protein PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a lipid …
Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.
Woodroof HI, Pogson JH, Begley M, Cantley LC, Deak M, Campbell DG, van Aalten DM, Whitworth AJ, Alessi DR, Muqit MM. Woodroof HI, et al. Open Biol. 2011 Nov;1(3):110012. doi: 10.1098/rsob.110012. Open Biol. 2011. PMID: 22645651 Free PMC article.
Missense mutations of the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) gene cause autosomal-recessive Parkinson's disease. ...We have also, for the first time, been able to investigate the effect of Parkinson's disease-a …
Missense mutations of the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) gene cause autosomal-re …