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Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin.
Miller AN, Vaisey G, Long SB. Miller AN, et al. Elife. 2019 Jan 10;8:e43231. doi: 10.7554/eLife.43231. Elife. 2019. PMID: 30628889 Free PMC article.
Bestrophin (BEST1-4) ligand-gated chloride (Cl(-)) channels are activated by calcium (Ca(2+)). Mutation of BEST1 causes retinal disease. Partly because bestrophin channels have no sequence or structural similarity to other i
Bestrophin (BEST1-4) ligand-gated chloride (Cl(-)) channels are activated by calcium (Ca(2+)). Mut
Calcium-activated chloride currents in olfactory sensory neurons from mice lacking bestrophin-2.
Pifferi S, Dibattista M, Sagheddu C, Boccaccio A, Al Qteishat A, Ghirardi F, Tirindelli R, Menini A. Pifferi S, et al. J Physiol. 2009 Sep 1;587(Pt 17):4265-79. doi: 10.1113/jphysiol.2009.176131. Epub 2009 Jul 21. J Physiol. 2009. PMID: 19622610 Free PMC article.
Ca(2+) activates a Cl(-) current that produces an efflux of Cl(-) ions and amplifies the depolarization. The molecular identity of Ca(2+)-activated Cl(-) channels is still elusive, although some bestrophins have been shown to function as Ca(2+)-acti
Ca(2+) activates a Cl(-) current that produces an efflux of Cl(-) ions and amplifies the depolarization. The molecular identity of Ca …
Structure and insights into the function of a Ca(2+)-activated Cl(-) channel.
Kane Dickson V, Pedi L, Long SB. Kane Dickson V, et al. Nature. 2014 Dec 11;516(7530):213-8. doi: 10.1038/nature13913. Epub 2014 Oct 22. Nature. 2014. PMID: 25337878 Free PMC article.
Bestrophin calcium-activated chloride channels (CaCCs) regulate the flow of chloride and other monovalent anions across cellular membranes in response to intracellular calcium (Ca(2+)) levels. ...Conformational changes observed nea
Bestrophin calcium-activated chloride channels (CaCCs) regulate the flow of chloride and other mon
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