Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2007 1
2008 1
2009 1
2012 1
2013 1
2014 1
2016 1
2019 2
2020 1
2021 1
2022 2
2024 1
2025 2

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

14 results

Results by year

Citations

1 article found by citation matching

Search results

Filters applied: . Clear all
Page 1
Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin.
Miller AN, Vaisey G, Long SB. Miller AN, et al. Elife. 2019 Jan 10;8:e43231. doi: 10.7554/eLife.43231. Elife. 2019. PMID: 30628889 Free PMC article.
Bestrophin (BEST1-4) ligand-gated chloride (Cl(-)) channels are activated by calcium (Ca(2+)). Mutation of BEST1 causes retinal disease. Partly because bestrophin channels have no sequence or structural similarity to other i …
Bestrophin (BEST1-4) ligand-gated chloride (Cl(-)) channels are activated by calcium (Ca(2+)). Mut …
Structure and Function of the Bestrophin family of calcium-activated chloride channels.
Owji AP, Kittredge A, Zhang Y, Yang T. Owji AP, et al. Channels (Austin). 2021 Dec;15(1):604-623. doi: 10.1080/19336950.2021.1981625. Channels (Austin). 2021. PMID: 34612806 Free PMC article. Review.
Bestrophins are a family of calcium-activated chloride channels (CaCCs) with relevance to human physiology and a myriad of eye diseases termed "bestrophinopathies". Since the identification of bestrophins as CaCCs nearly two decades ago, …
Bestrophins are a family of calcium-activated chloride channels (CaCCs) with relevance to human physiolog …
Structures and gating mechanisms of human bestrophin anion channels.
Owji AP, Wang J, Kittredge A, Clark Z, Zhang Y, Hendrickson WA, Yang T. Owji AP, et al. Nat Commun. 2022 Jul 4;13(1):3836. doi: 10.1038/s41467-022-31437-7. Nat Commun. 2022. PMID: 35789156 Free PMC article.
Bestrophin-1 (Best1) and bestrophin-2 (Best2) are two members of the bestrophin family of calcium (Ca(2+))-activated chloride (Cl(-)) channels with critical involvement in ocular physiology and direct pathological relevance. ...Com …
Bestrophin-1 (Best1) and bestrophin-2 (Best2) are two members of the bestrophin family of calcium (Ca(2+))-ac …
Calcium-activated chloride currents in olfactory sensory neurons from mice lacking bestrophin-2.
Pifferi S, Dibattista M, Sagheddu C, Boccaccio A, Al Qteishat A, Ghirardi F, Tirindelli R, Menini A. Pifferi S, et al. J Physiol. 2009 Sep 1;587(Pt 17):4265-79. doi: 10.1113/jphysiol.2009.176131. Epub 2009 Jul 21. J Physiol. 2009. PMID: 19622610 Free PMC article.
Ca(2+) activates a Cl(-) current that produces an efflux of Cl(-) ions and amplifies the depolarization. The molecular identity of Ca(2+)-activated Cl(-) channels is still elusive, although some bestrophins have been shown to function as Ca(2+)-acti …
Ca(2+) activates a Cl(-) current that produces an efflux of Cl(-) ions and amplifies the depolarization. The molecular identity of Ca …
The pentameric chloride channel BEST1 is activated by extracellular GABA.
Pant S, Tam SW, Long SB. Pant S, et al. Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2424474122. doi: 10.1073/pnas.2424474122. Epub 2025 Apr 18. Proc Natl Acad Sci U S A. 2025. PMID: 40249777
Bestrophin-1 (BEST1) is a chloride channel expressed in the eye and other tissues of the body. ...The most appreciated receptors for extracellular GABA are the GABA(B) G-protein-coupled receptors and the pentameric GABA(A) chloride channels, bot …
Bestrophin-1 (BEST1) is a chloride channel expressed in the eye and other tissues of the body. ...The most appreciated …
Cryo-EM structures of thylakoid-located voltage-dependent chloride channel VCCN1.
Hagino T, Kato T, Kasuya G, Kobayashi K, Kusakizako T, Hamamoto S, Sobajima T, Fujiwara Y, Yamashita K, Kawasaki H, Maturana AD, Nishizawa T, Nureki O. Hagino T, et al. Nat Commun. 2022 May 6;13(1):2505. doi: 10.1038/s41467-022-30292-w. Nat Commun. 2022. PMID: 35523970 Free PMC article.
VCCN1 was recently identified as a voltage-gated chloride channel residing in the thylakoid membrane, where it plays a key role in photoreaction tuning to avoid the generation of reactive oxygen species (ROS). ...VCCN1 structurally resembles its animal homolo …
VCCN1 was recently identified as a voltage-gated chloride channel residing in the thylakoid membrane, where it plays a …
Role of Cl(-) channels in primary brain tumour.
Saberbaghi T, Wong R, Rutka JT, Wang GL, Feng ZP, Sun HS. Saberbaghi T, et al. Cell Calcium. 2019 Jul;81:1-11. doi: 10.1016/j.ceca.2019.05.004. Epub 2019 May 14. Cell Calcium. 2019. PMID: 31129471 Review.
Glioma is the predominant malignant primary brain tumour, accounting for 80% of all cases. Voltage-gated Cl(-) channel family (ClC) proteins and Cl(-) intracellular channel (CLIC) proteins are drastically overexpressed in glioma, and are associated with enhan …
Glioma is the predominant malignant primary brain tumour, accounting for 80% of all cases. Voltage-gated Cl(-) channel family …
Transport and function of chloride in vascular smooth muscles.
Matchkov VV, Secher Dam V, Bødtkjer DM, Aalkjær C. Matchkov VV, et al. J Vasc Res. 2013;50(1):69-87. doi: 10.1159/000345242. Epub 2012 Nov 17. J Vasc Res. 2013. PMID: 23172353 Review.
The cystic fibrosis transmembrane conductance regulator is also demonstrated in VSMCs. The molecular identity of the major anion conductance in VSMCs - a Ca(2+)-activated Cl(-) current - is uncertain. Several candidates have been suggested with bestrophin and …
The cystic fibrosis transmembrane conductance regulator is also demonstrated in VSMCs. The molecular identity of the major anion cond …
A quantitative analysis of bestrophin 1 cellular localization in mouse cerebral cortex.
Di Palma M, Koh W, Lee CJ, Conti F. Di Palma M, et al. Acta Physiol (Oxf). 2025 Jan;241(1):e14245. doi: 10.1111/apha.14245. Epub 2024 Oct 28. Acta Physiol (Oxf). 2025. PMID: 39466647 Free PMC article.
AIM: Calcium-activated ligand-gated chloride channels, beyond their role in maintaining anion homeostasis, modulate neuronal excitability by facilitating nonvesicular neurotransmitter release. ...Understanding BEST1's function in these cells cou …
AIM: Calcium-activated ligand-gated chloride channels, beyond their role in maintaining anion homeostasis …
Structure and insights into the function of a Ca(2+)-activated Cl(-) channel.
Kane Dickson V, Pedi L, Long SB. Kane Dickson V, et al. Nature. 2014 Dec 11;516(7530):213-8. doi: 10.1038/nature13913. Epub 2014 Oct 22. Nature. 2014. PMID: 25337878 Free PMC article.
Bestrophin calcium-activated chloride channels (CaCCs) regulate the flow of chloride and other monovalent anions across cellular membranes in response to intracellular calcium (Ca(2+)) levels. ...Conformational changes observed nea …
Bestrophin calcium-activated chloride channels (CaCCs) regulate the flow of chloride and other mon …
14 results