Search Page
Save citations to file
Email citations
Send citations to clipboard
Add to Collections
Add to My Bibliography
Create a file for external citation management software
Your saved search
Your RSS Feed
Search Results
7 results
Filters applied: . Clear all
Results are displayed in a computed author sort order.
The Results By Year timeline is not available.
Page 1
Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151).
J Med Chem. 2002 Aug 29;45(18):3878-90. doi: 10.1021/jm020881f.
J Med Chem. 2002.
PMID: 12190311
Syntheses of trans-5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-oxo-hexahydro-furo[3,2-b]pyrroles (pyrrolidine trans-lactams and trans-lactones): new pharmacophores for elastase inhibition.
Macdonald SJ, Belton DJ, Buckley DM, Spooner JE, Anson MS, Harrison LA, Mills K, Upton RJ, Dowle MD, Smith RA, Molloy CR, Risley C.
Macdonald SJ, et al. Among authors: molloy cr.
J Med Chem. 1998 Oct 8;41(21):3919-22. doi: 10.1021/jm981026s.
J Med Chem. 1998.
PMID: 9767628
No abstract available.
Item in Clipboard
Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams.
Macdonald SJ, Dowle MD, Harrison LA, Spooner JE, Shah P, Johnson MR, Inglis GG, Clarke GD, Belton DJ, Smith RA, Molloy CR, Dixon M, Murkitt G, Godward RE, Skarzynski T, Singh OM, Kumar KA, Hodgson ST, McDonald E, Hardy GW, Finch H, Humphreys DC, Fleetwood G.
Macdonald SJ, et al. Among authors: molloy cr.
Bioorg Med Chem Lett. 2001 Jan 22;11(2):243-6. doi: 10.1016/s0960-894x(00)00632-6.
Bioorg Med Chem Lett. 2001.
PMID: 11206469
Item in Clipboard
The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate.
Macdonald SJ, Dowle MD, Harrison LA, Shah P, Johnson MR, Inglis GG, Clarke GD, Smith RA, Humphreys D, Molloy CR, Amour A, Dixon M, Murkitt G, Godward RE, Padfield T, Skarzynski T, Singh OM, Kumar KA, Fleetwood G, Hodgson ST, Hardy GW, Finch H.
Macdonald SJ, et al. Among authors: molloy cr.
Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8. doi: 10.1016/s0960-894x(01)00078-6.
Bioorg Med Chem Lett. 2001.
PMID: 11294386
Item in Clipboard
6,6'-Bis(2-hydroxyphenyl)-2,2'-bipyridine manganese(III) complexes: a novel series of superoxide dismutase and catalase mimetics.
Giblin GM, Box PC, Campbell IB, Hancock AP, Roomans S, Mills GI, Molloy C, Tranter GE, Walker AL, Doctrow SR, Huffman K, Malfroy B.
Giblin GM, et al.
Bioorg Med Chem Lett. 2001 Jun 4;11(11):1367-70. doi: 10.1016/s0960-894x(01)00217-7.
Bioorg Med Chem Lett. 2001.
PMID: 11378356
Item in Clipboard
Oxidative neuropathology and putative chemical entities for Alzheimer's disease: neuroprotective effects of salen-manganese catalytic anti-oxidants.
Rupniak HT, Joy KA, Atkin C, Brown G, Barnes JC, Doctrow SR, Malfroy B, Wong T, Anderson IK, Molloy CR, Mills GI, Soden P.
Rupniak HT, et al. Among authors: molloy cr.
Neurotox Res. 2000;2(2-3):167-78. doi: 10.1007/BF03033792.
Neurotox Res. 2000.
PMID: 16787839
Item in Clipboard
A microplate assay measuring chloride ion channel activity.
West MR, Molloy CR.
West MR, et al. Among authors: molloy cr.
Anal Biochem. 1996 Oct 1;241(1):51-8. doi: 10.1006/abio.1996.0377.
Anal Biochem. 1996.
PMID: 8921165
Item in Clipboard
Cite
Cite