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Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Wyllie S, Brand S, Thomas M, De Rycker M, Chung CW, Pena I, Bingham RP, Bueren-Calabuig JA, Cantizani J, Cebrian D, Craggs PD, Ferguson L, Goswami P, Hobrath J, Howe J, Jeacock L, Ko EJ, Korczynska J, MacLean L, Manthri S, Martinez MS, Mata-Cantero L, Moniz S, Nühs A, Osuna-Cabello M, Pinto E, Riley J, Robinson S, Rowland P, Simeons FRC, Shishikura Y, Spinks D, Stojanovski L, Thomas J, Thompson S, Viayna Gaza E, Wall RJ, Zuccotto F, Horn D, Ferguson MAJ, Fairlamb AH, Fiandor JM, Martin J, Gray DW, Miles TJ, Gilbert IH, Read KD, Marco M, Wyatt PG. Wyllie S, et al. Among authors: moniz s. Proc Natl Acad Sci U S A. 2019 May 7;116(19):9318-9323. doi: 10.1073/pnas.1820175116. Epub 2019 Apr 8. Proc Natl Acad Sci U S A. 2019. PMID: 30962368 Free PMC article.
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani.
Corpas-Lopez V, Moniz S, Thomas M, Wall RJ, Torrie LS, Zander-Dinse D, Tinti M, Brand S, Stojanovski L, Manthri S, Hallyburton I, Zuccotto F, Wyatt PG, De Rycker M, Horn D, Ferguson MAJ, Clos J, Read KD, Fairlamb AH, Gilbert IH, Wyllie S. Corpas-Lopez V, et al. Among authors: moniz s. ACS Infect Dis. 2019 Jan 11;5(1):111-122. doi: 10.1021/acsinfecdis.8b00226. Epub 2018 Nov 12. ACS Infect Dis. 2019. PMID: 30380837 Free PMC article.
The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani.
Wall RJ, Carvalho S, Milne R, Bueren-Calabuig JA, Moniz S, Cantizani-Perez J, MacLean L, Kessler A, Cotillo I, Sastry L, Manthri S, Patterson S, Zuccotto F, Thompson S, Martin J, Marco M, Miles TJ, De Rycker M, Thomas MG, Fairlamb AH, Gilbert IH, Wyllie S. Wall RJ, et al. Among authors: moniz s. ACS Infect Dis. 2020 Mar 13;6(3):515-528. doi: 10.1021/acsinfecdis.9b00426. Epub 2020 Jan 30. ACS Infect Dis. 2020. PMID: 31967783 Free PMC article.
Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease.
Lima ML, Tulloch LB, Corpas-Lopez V, Carvalho S, Wall RJ, Milne R, Rico E, Patterson S, Gilbert IH, Moniz S, MacLean L, Torrie LS, Morgillo C, Horn D, Zuccotto F, Wyllie S. Lima ML, et al. Among authors: moniz s. Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0153521. doi: 10.1128/AAC.01535-21. Epub 2021 Oct 4. Antimicrob Agents Chemother. 2022. PMID: 34606338 Free PMC article.
Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals.
Wall RJ, Moniz S, Thomas MG, Norval S, Ko EJ, Marco M, Miles TJ, Gilbert IH, Horn D, Fairlamb AH, Wyllie S. Wall RJ, et al. Among authors: moniz s. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00235-18. doi: 10.1128/AAC.00235-18. Print 2018 Aug. Antimicrob Agents Chemother. 2018. PMID: 29844044 Free PMC article.
Cezanne regulates E2F1-dependent HIF2α expression.
Moniz S, Bandarra D, Biddlestone J, Campbell KJ, Komander D, Bremm A, Rocha S. Moniz S, et al. J Cell Sci. 2015 Aug 15;128(16):3082-93. doi: 10.1242/jcs.168864. Epub 2015 Jul 6. J Cell Sci. 2015. PMID: 26148512 Free PMC article.
46 results