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691 results
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A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds.
Cairney CJ, Godwin LS, Bilsland AE, Burns S, Stevenson KH, McGarry L, Revie J, Moore JD, Wiggins CM, Collinson RS, Mudd C, Tsonou E, Sadaie M, Bennett DC, Narita M, Torrance CJ, Keith WN. Cairney CJ, et al. Among authors: moore jd. PLoS Genet. 2017 Aug 14;13(8):e1006942. doi: 10.1371/journal.pgen.1006942. eCollection 2017 Aug. PLoS Genet. 2017. PMID: 28806777 Free PMC article.
A Medium-Throughput Single Cell CRISPR-Cas9 Assay to Assess Gene Essentiality.
Grassian AR, Scales TME, Knutson SK, Kuntz KW, McCarthy NJ, Lowe CE, Moore JD, Copeland RA, Keilhack H, Smith JJ, Wickenden JA, Ribich S. Grassian AR, et al. Among authors: moore jd. Biol Proced Online. 2015 Nov 14;17:15. doi: 10.1186/s12575-015-0028-4. eCollection 2015. Biol Proced Online. 2015. PMID: 26578851 Free PMC article.
Increasing the performance of pooled CRISPR-Cas9 drop-out screening.
Cross BC, Lawo S, Archer CR, Hunt JR, Yarker JL, Riccombeni A, Little AS, McCarthy NJ, Moore JD. Cross BC, et al. Among authors: moore jd. Sci Rep. 2016 Aug 22;6:31782. doi: 10.1038/srep31782. Sci Rep. 2016. PMID: 27545104 Free PMC article.
Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib.
Miller RE, Brough R, Bajrami I, Williamson CT, McDade S, Campbell J, Kigozi A, Rafiq R, Pemberton H, Natrajan R, Joel J, Astley H, Mahoney C, Moore JD, Torrance C, Gordan JD, Webber JT, Levin RS, Shokat KM, Bandyopadhyay S, Lord CJ, Ashworth A. Miller RE, et al. Among authors: moore jd. Mol Cancer Ther. 2016 Jul;15(7):1472-84. doi: 10.1158/1535-7163.MCT-15-0554. Epub 2016 Jun 30. Mol Cancer Ther. 2016. PMID: 27364904
VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells.
Moore JD, Staniszewska A, Shaw T, D'Alessandro J, Davis B, Surgenor A, Baker L, Matassova N, Murray J, Macias A, Brough P, Wood M, Mahon PC. Moore JD, et al. Oncotarget. 2014 Dec 30;5(24):12862-76. doi: 10.18632/oncotarget.2656. Oncotarget. 2014. PMID: 25404640 Free PMC article.
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