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Discovery of tertiary sulfonamides as potent liver X receptor antagonists.
Zuercher WJ, Buckholz RG, Campobasso N, Collins JL, Galardi CM, Gampe RT, Hyatt SM, Merrihew SL, Moore JT, Oplinger JA, Reid PR, Spearing PK, Stanley TB, Stewart EL, Willson TM. Zuercher WJ, et al. Among authors: moore jt. J Med Chem. 2010 Apr 22;53(8):3412-6. doi: 10.1021/jm901797p. J Med Chem. 2010. PMID: 20345102
The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor.
Wang H, Li H, Moore LB, Johnson MD, Maglich JM, Goodwin B, Ittoop OR, Wisely B, Creech K, Parks DJ, Collins JL, Willson TM, Kalpana GV, Venkatesh M, Xie W, Cho SY, Roboz J, Redinbo M, Moore JT, Mani S. Wang H, et al. Among authors: moore lb, moore jt. Mol Endocrinol. 2008 Apr;22(4):838-57. doi: 10.1210/me.2007-0218. Epub 2007 Dec 20. Mol Endocrinol. 2008. PMID: 18096694 Free PMC article.
The nuclear receptor superfamily and drug discovery.
Moore JT, Collins JL, Pearce KH. Moore JT, et al. ChemMedChem. 2006 May;1(5):504-23. doi: 10.1002/cmdc.200600006. ChemMedChem. 2006. PMID: 16892386 Review. No abstract available.
CAR: detailing new models.
Goodwin B, Moore JT. Goodwin B, et al. Among authors: moore jt. Trends Pharmacol Sci. 2004 Aug;25(8):437-41. doi: 10.1016/j.tips.2004.06.007. Trends Pharmacol Sci. 2004. PMID: 15276713 Review.
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