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Discovery of tertiary sulfonamides as potent liver X receptor antagonists.
Zuercher WJ, Buckholz RG, Campobasso N, Collins JL, Galardi CM, Gampe RT, Hyatt SM, Merrihew SL, Moore JT, Oplinger JA, Reid PR, Spearing PK, Stanley TB, Stewart EL, Willson TM. Zuercher WJ, et al. Among authors: Moore JT. J Med Chem. 2010 Apr 22;53(8):3412-6. doi: 10.1021/jm901797p. J Med Chem. 2010. PMID: 20345102
The nuclear receptor superfamily and drug discovery.
Moore JT, Collins JL, Pearce KH. Moore JT, et al. ChemMedChem. 2006 May;1(5):504-23. doi: 10.1002/cmdc.200600006. ChemMedChem. 2006. PMID: 16892386 Review. No abstract available.
A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.
Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT. Xu RX, et al. Among authors: Moore LB, Moore JT. Mol Cell. 2004 Dec 22;16(6):919-28. doi: 10.1016/j.molcel.2004.11.042. Mol Cell. 2004. PMID: 15610735
CAR: detailing new models.
Goodwin B, Moore JT. Goodwin B, et al. Among authors: Moore JT. Trends Pharmacol Sci. 2004 Aug;25(8):437-41. doi: 10.1016/j.tips.2004.06.007. Trends Pharmacol Sci. 2004. PMID: 15276713 Review.
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.
Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT. Maglich JM, et al. Among authors: Moore LB, Moore JT. J Biol Chem. 2003 May 9;278(19):17277-83. doi: 10.1074/jbc.M300138200. Epub 2003 Feb 27. J Biol Chem. 2003. PMID: 12611900
Functional and structural comparison of PXR and CAR.
Moore JT, Moore LB, Maglich JM, Kliewer SA. Moore JT, et al. Among authors: Moore LB. Biochim Biophys Acta. 2003 Feb 17;1619(3):235-8. doi: 10.1016/s0304-4165(02)00481-6. Biochim Biophys Acta. 2003. PMID: 12573482 Review.
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