Moore JT - Search Results

1

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, Kliewer SA. Lehmann JM, et al. Among authors: moore jt. J Clin Invest. 1998 Sep 1;102(5):1016-23. doi: 10.1172/JCI3703. J Clin Invest. 1998. PMID: 9727070 Free PMC article.

2

Discovery of tertiary sulfonamides as potent liver X receptor antagonists.

Zuercher WJ, Buckholz RG, Campobasso N, Collins JL, Galardi CM, Gampe RT, Hyatt SM, Merrihew SL, Moore JT, Oplinger JA, Reid PR, Spearing PK, Stanley TB, Stewart EL, Willson TM. Zuercher WJ, et al. Among authors: moore jt. J Med Chem. 2010 Apr 22;53(8):3412-6. doi: 10.1021/jm901797p. J Med Chem. 2010. PMID: 20345102

3

The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily.

Maglich JM, Caravella JA, Lambert MH, Willson TM, Moore JT, Ramamurthy L. Maglich JM, et al. Among authors: moore jt. Nucleic Acids Res. 2003 Jul 15;31(14):4051-8. doi: 10.1093/nar/gkg444. Nucleic Acids Res. 2003. PMID: 12853622 Free PMC article.

4

Beyond the human genome: examples of nuclear receptor analysis in model organisms and potential for drug discovery.

Maglich JM, Sluder AE, Willson TM, Moore JT. Maglich JM, et al. Among authors: moore jt. Am J Pharmacogenomics. 2003;3(5):345-53. doi: 10.2165/00129785-200303050-00005. Am J Pharmacogenomics. 2003. PMID: 14575522 Review.

5

The nuclear receptor superfamily and drug discovery.

Moore JT, Collins JL, Pearce KH. Moore JT, et al. ChemMedChem. 2006 May;1(5):504-23. doi: 10.1002/cmdc.200600006. ChemMedChem. 2006. PMID: 16892386 Review. No abstract available.

6

A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.

Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT. Xu RX, et al. Among authors: moore lb, moore jt. Mol Cell. 2004 Dec 22;16(6):919-28. doi: 10.1016/j.molcel.2004.11.042. Mol Cell. 2004. PMID: 15610735

7

CAR: detailing new models.

Goodwin B, Moore JT. Goodwin B, et al. Among authors: moore jt. Trends Pharmacol Sci. 2004 Aug;25(8):437-41. doi: 10.1016/j.tips.2004.06.007. Trends Pharmacol Sci. 2004. PMID: 15276713 Review.

8

The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.

Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT. Maglich JM, et al. Among authors: moore jt. J Biol Chem. 2004 May 7;279(19):19832-8. doi: 10.1074/jbc.M313601200. Epub 2004 Mar 5. J Biol Chem. 2004. PMID: 15004031

9

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.

Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT. Maglich JM, et al. Among authors: moore lb, moore jt. J Biol Chem. 2003 May 9;278(19):17277-83. doi: 10.1074/jbc.M300138200. Epub 2003 Feb 27. J Biol Chem. 2003. PMID: 12611900

10

Functional and structural comparison of PXR and CAR.

Moore JT, Moore LB, Maglich JM, Kliewer SA. Moore JT, et al. Among authors: moore lb. Biochim Biophys Acta. 2003 Feb 17;1619(3):235-8. doi: 10.1016/s0304-4165(02)00481-6. Biochim Biophys Acta. 2003. PMID: 12573482 Review.

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