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Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.
Nakao A, Afrakhte M, Morén A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P. Nakao A, et al. Among authors: moren a. Nature. 1997 Oct 9;389(6651):631-5. doi: 10.1038/39369. Nature. 1997. PMID: 9335507
TGF-beta rapidly induces expression of Smad7 mRNA, suggesting that Smad7 may participate in a negative feedback loop to control TGF-beta responses....
TGF-beta rapidly induces expression of Smad7 mRNA, suggesting that Smad7 may participate in a negative feedback loop to control TGF-b …
Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors.
Morén A, Ichijo H, Miyazono K. Morén A, et al. Biochem Biophys Res Commun. 1992 Nov 30;189(1):356-62. doi: 10.1016/0006-291x(92)91566-9. Biochem Biophys Res Commun. 1992. PMID: 1333192
The human TGF-beta type III receptor coding region encodes a protein of 849 amino acids with a single transmembrane domain and a short stretch of the intracellular domain. ...A high degree of sequence conservation was observed in the transmembrane and …
The human TGF-beta type III receptor coding region encodes a protein of 849 amino acids with a single transmembrane domain and …
TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences.
Kanzaki T, Olofsson A, Morén A, Wernstedt C, Hellman U, Miyazono K, Claesson-Welsh L, Heldin CH. Kanzaki T, et al. Among authors: moren a. Cell. 1990 Jun 15;61(6):1051-61. doi: 10.1016/0092-8674(90)90069-q. Cell. 1990. PMID: 2350783
TGF-beta occurs in a latent complex of high Mr. We report the cDNA cloning and an initial structural and functional characterization of a component of the large latent TGF-beta 1 complex, denoted TGF-beta 1 binding protein (TGF-beta 1-BP). Most of the sequence of fi …
TGF-beta occurs in a latent complex of high Mr. We report the cDNA cloning and an initial structural and functional characterization …
cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules.
Claesson-Welsh L, Eriksson A, Morén A, Severinsson L, Ek B, Ostman A, Betsholtz C, Heldin CH. Claesson-Welsh L, et al. Among authors: moren a. Mol Cell Biol. 1988 Aug;8(8):3476-86. doi: 10.1128/mcb.8.8.3476. Mol Cell Biol. 1988. PMID: 2850496 Free PMC article.
A 5.45-kilobase-pair cDNA clone predicts a 1,106-amino-acid polypeptide, including the cleavable signal sequence. The overall amino acid sequence similarity with the murine PDGF receptor is 85%. After transcription of the cDNA and translation in vitro, a PDGF
A 5.45-kilobase-pair cDNA clone predicts a 1,106-amino-acid polypeptide, including the cleavable signal sequence. The overall
Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein.
Morén A, Olofsson A, Stenman G, Sahlin P, Kanzaki T, Claesson-Welsh L, ten Dijke P, Miyazono K, Heldin CH. Morén A, et al. J Biol Chem. 1994 Dec 23;269(51):32469-78. J Biol Chem. 1994. PMID: 7798248
Here we report the identification of a novel protein termed LTBP-2, which is structurally related to LTBP. cDNA for LTBP-2 was obtained from human foreskin fibroblast cDNA libraries using a fragment of the LTBP cDNA as a probe. ...Similar to LTBP, a co …
Here we report the identification of a novel protein termed LTBP-2, which is structurally related to LTBP. cDNA for LTBP-2 was obtain …
Distinct roles of the intracellular domains of transforming growth factor-beta type I and type II receptors in signal transduction.
Okadome T, Yamashita H, Franzén P, Morén A, Heldin CH, Miyazono K. Okadome T, et al. Among authors: moren a. J Biol Chem. 1994 Dec 9;269(49):30753-6. J Biol Chem. 1994. PMID: 7983000
When transfected into a mutant mink lung epithelial cell line that lacks functional T beta R-II, T beta R-II cDNA, but not T beta R-2.1 cDNA, restored the responsiveness to TGF-beta 1 with regard to transcriptional activation of plasminogen activator inhibitor-1 gene promo …
When transfected into a mutant mink lung epithelial cell line that lacks functional T beta R-II, T beta R-II cDNA, but not T beta R-2 …
Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta.
Yamashita H, Ichijo H, Grimsby S, Morén A, ten Dijke P, Miyazono K. Yamashita H, et al. Among authors: moren a. J Biol Chem. 1994 Jan 21;269(3):1995-2001. J Biol Chem. 1994. PMID: 8294451
Human endoglin is a dimeric protein that binds transforming growth factor-beta (TGF-beta). A porcine cDNA clone for endoglin was obtained from a porcine uterus cDNA library. ...These results revealed that endoglin is a phosphorylated protein which form …
Human endoglin is a dimeric protein that binds transforming growth factor-beta (TGF-beta). A porcine cDNA clone for endoglin w …
Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix.
Olofsson A, Ichijo H, Morén A, ten Dijke P, Miyazono K, Heldin CH. Olofsson A, et al. Among authors: moren a. J Biol Chem. 1995 Dec 29;270(52):31294-7. doi: 10.1074/jbc.270.52.31294. J Biol Chem. 1995. PMID: 8537398
Latent transforming growth factor-beta (TGF-beta) binding protein-1 (LTBP-1) is a component of the high molecular weight latent TGF-beta complex found in various cells, including human platelets. ...We here report a novel form of human LTBP-1, which is longer in its …
Latent transforming growth factor-beta (TGF-beta) binding protein-1 (LTBP-1) is a component of the high molecular weight latent TGF-b …
Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160.
Olofsson A, Hellman U, Ten Dijke P, Grimsby S, Ichijo H, Morén A, Miyazono K, Heldin CH. Olofsson A, et al. Among authors: moren a. Biochem J. 1997 Jun 1;324 ( Pt 2)(Pt 2):427-34. doi: 10.1042/bj3240427. Biochem J. 1997. PMID: 9182700 Free PMC article.
In Chinese hamster ovary (CHO) cells transfected with the TGF-beta1 cDNA, a major part of the latent TGF-beta secreted into the medium is a 100-kDa small latent complex containing TGF-beta and LAP. In addition, we found two other forms of latent TGF-beta complexes, …
In Chinese hamster ovary (CHO) cells transfected with the TGF-beta1 cDNA, a major part of the latent TGF-beta secreted into the mediu …
Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members.
Afrakhte M, Morén A, Jossan S, Itoh S, Sampath K, Westermark B, Heldin CH, Heldin NE, ten Dijke P. Afrakhte M, et al. Among authors: moren a. Biochem Biophys Res Commun. 1998 Aug 19;249(2):505-11. doi: 10.1006/bbrc.1998.9170. Biochem Biophys Res Commun. 1998. PMID: 9712726
Ectopic expression of anti-sense Smad7 RNA was found to increase the effect of TGF-beta1, supporting its role as a negative regulator in TGF-beta signaling. ...
Ectopic expression of anti-sense Smad7 RNA was found to increase the effect of TGF-beta1, supporting its role as a negative regulator …
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