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AP-1 and retromer play opposite roles in the trafficking of sortilin between the Golgi apparatus and the lysosomes.
Canuel M, Lefrancois S, Zeng J, Morales CR. Canuel M, et al. Among authors: morales cr. Biochem Biophys Res Commun. 2008 Feb 15;366(3):724-30. doi: 10.1016/j.bbrc.2007.12.015. Epub 2007 Dec 17. Biochem Biophys Res Commun. 2008. PMID: 18078806
Targeting exogenous β-Defensin to the endolysosomal compartment via a vehicle guided system.
Carvelli L, Libin Y, Esfandnia S, Zhang Y, Presley JF, Morales CR. Carvelli L, et al. Among authors: morales cr. Histol Histopathol. 2017 Oct;32(10):1017-1027. doi: 10.14670/HH-11-862. Epub 2016 Dec 29. Histol Histopathol. 2017. PMID: 28032328
The intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft trafficking.
Yang M, Virassamy B, Vijayaraj SL, Lim Y, Saadipour K, Wang YJ, Han YC, Zhong JH, Morales CR, Zhou XF. Yang M, et al. Among authors: morales cr. PLoS One. 2013 May 21;8(5):e63049. doi: 10.1371/journal.pone.0063049. Print 2013. PLoS One. 2013. PMID: 23704887 Free PMC article.
Sortilin regulates sorting and secretion of Sonic hedgehog.
Campbell C, Beug S, Nickerson PE, Peng J, Mazerolle C, Bassett EA, Ringuette R, Jama FA, Morales C, Christ A, Wallace VA. Campbell C, et al. Among authors: morales c. J Cell Sci. 2016 Oct 15;129(20):3832-3844. doi: 10.1242/jcs.183541. Epub 2016 Sep 15. J Cell Sci. 2016. PMID: 27632999
The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes.
Zeng J, Racicott J, Morales CR. Zeng J, et al. Among authors: morales cr. Exp Cell Res. 2009 Nov 1;315(18):3112-24. doi: 10.1016/j.yexcr.2009.08.016. Epub 2009 Sep 2. Exp Cell Res. 2009. PMID: 19732768
Inactivation of sortilin (a novel lysosomal sorting receptor) by dominant negative competition and RNA interference.
Lefrancois S, Canuel M, Zeng J, Morales CR. Lefrancois S, et al. Among authors: morales cr. Biol Proced Online. 2005;7:17-25. doi: 10.1251/bpo101. Epub 2005 Jan 25. Biol Proced Online. 2005. PMID: 15682222 Free PMC article.
Study of the mouse sortilin gene: Effects of its transient silencing by RNA interference in TM4 Sertoli cells.
Zeng J, Hassan AJ, Morales CR. Zeng J, et al. Among authors: morales cr. Mol Reprod Dev. 2004 Aug;68(4):469-75. doi: 10.1002/mrd.20097. Mol Reprod Dev. 2004. PMID: 15236332
ATP-binding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa.
Morales CR, Marat AL, Ni X, Yu Y, Oko R, Smith BT, Argraves WS. Morales CR, et al. Biochem Biophys Res Commun. 2008 Nov 21;376(3):472-7. doi: 10.1016/j.bbrc.2008.09.009. Epub 2008 Sep 13. Biochem Biophys Res Commun. 2008. PMID: 18793613 Free PMC article.
ProNGF induces TNFalpha-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway.
Lebrun-Julien F, Bertrand MJ, De Backer O, Stellwagen D, Morales CR, Di Polo A, Barker PA. Lebrun-Julien F, et al. Among authors: morales cr. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3817-22. doi: 10.1073/pnas.0909276107. Epub 2010 Feb 3. Proc Natl Acad Sci U S A. 2010. PMID: 20133718 Free PMC article.
Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis.
Patel KM, Strong A, Tohyama J, Jin X, Morales CR, Billheimer J, Millar J, Kruth H, Rader DJ. Patel KM, et al. Among authors: morales cr. Circ Res. 2015 Feb 27;116(5):789-96. doi: 10.1161/CIRCRESAHA.116.305811. Epub 2015 Jan 15. Circ Res. 2015. PMID: 25593281 Free PMC article.
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