Altered X-chromosome inactivation predisposes to autoimmunity.
Huret C, Ferrayé L, David A, Mohamed M, Valentin N, Charlotte F, Savignac M, Goodhardt M, Guéry JC, Rougeulle C, Morey C.
Huret C, et al. Among authors: morey c.
Sci Adv. 2024 May 3;10(18):eadn6537. doi: 10.1126/sciadv.adn6537. Epub 2024 May 3.
Sci Adv. 2024.
PMID: 38701219
Free PMC article.
We perturbed the expression of the trigger of XCI, the noncoding RNA Xist, in female mice. This resulted in reactivation of genes on the inactive X, including members of the Toll-like receptor 7 (TLR7) signaling pathway, in monocyte/macrophages and dendritic and B cells. C …
We perturbed the expression of the trigger of XCI, the noncoding RNA Xist, in female mice. This resulted in reactivation of genes on …