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Complement, a target for therapy in inflammatory and degenerative diseases.
Morgan BP, Harris CL. Morgan BP, et al. Nat Rev Drug Discov. 2015 Dec;14(12):857-77. doi: 10.1038/nrd4657. Epub 2015 Oct 23. Nat Rev Drug Discov. 2015. PMID: 26493766 Free PMC article. Review.
Introduction to complement in health and disease: novel aspects and insights.
Morgan BP, Kavanagh D. Morgan BP, et al. Semin Immunopathol. 2018 Jan;40(1):1-2. doi: 10.1007/s00281-017-0664-7. Epub 2018 Jan 8. Semin Immunopathol. 2018. PMID: 29313086 No abstract available.
Plasma complement biomarkers distinguish multiple sclerosis and neuromyelitis optica spectrum disorder.
Hakobyan S, Luppe S, Evans DR, Harding K, Loveless S, Robertson NP, Morgan BP. Hakobyan S, et al. Among authors: morgan bp. Mult Scler. 2017 Jun;23(7):946-955. doi: 10.1177/1352458516669002. Epub 2016 Sep 9. Mult Scler. 2017. PMID: 27613120
Complement system activation contributes to the ependymal damage induced by microbial neuraminidase.
Granados-Durán P, López-Ávalos MD, Hughes TR, Johnson K, Morgan BP, Tamburini PP, Fernández-Llebrez P, Grondona JM. Granados-Durán P, et al. Among authors: morgan bp. J Neuroinflammation. 2016 May 21;13(1):115. doi: 10.1186/s12974-016-0576-9. J Neuroinflammation. 2016. PMID: 27209022 Free PMC article.
CD55 in rat male reproductive tissue: differential expression in testis and expression of a unique truncated isoform on spermatozoa.
Mizuno M, Donev RM, Harris CL, Morgan BP. Mizuno M, et al. Among authors: morgan bp. Mol Immunol. 2007 Mar;44(7):1613-22. doi: 10.1016/j.molimm.2006.08.018. Epub 2006 Sep 27. Mol Immunol. 2007. PMID: 17007930
Characterizing a pH-switch anti-C5 antibody as a tool for human and mouse complement C5 purification and cross-species inhibition of classical and reactive lysis.
Zelek WM, Stott M, Walters D, Harris CL, Morgan BP. Zelek WM, et al. Among authors: morgan bp. Immunology. 2018 Nov;155(3):396-403. doi: 10.1111/imm.12982. Epub 2018 Jul 30. Immunology. 2018. PMID: 29981529 Free PMC article.
A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases.
Owen EP, Würzner R, Leisegang F, Rizkallah P, Whitelaw A, Simpson J, Thomas AD, Harris CL, Giles JL, Hellerud BC, Mollnes TE, Morgan BP, Potter PC, Orren A. Owen EP, et al. Among authors: morgan bp. Mol Immunol. 2015 Mar;64(1):170-6. doi: 10.1016/j.molimm.2014.11.010. Epub 2014 Dec 19. Mol Immunol. 2015. PMID: 25534848
Complement-induced protection: an explanation for the limitations of cell-based tumour immunotherapies.
Kempshall E, Thebault S, Morgan BP, Harris CL, Gallimore A. Kempshall E, et al. Among authors: morgan bp. Immunol Cell Biol. 2012 Oct;90(9):869-71. doi: 10.1038/icb.2012.30. Epub 2012 Jul 10. Immunol Cell Biol. 2012. PMID: 22777521
TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2.
Raby AC, Holst B, Davies J, Colmont C, Laumonnier Y, Coles B, Shah S, Hall J, Topley N, Köhl J, Morgan BP, Labéta MO. Raby AC, et al. Among authors: morgan bp. Eur J Immunol. 2011 Sep;41(9):2741-52. doi: 10.1002/eji.201041350. Epub 2011 Aug 4. Eur J Immunol. 2011. PMID: 21630250 Free PMC article.
Crry deficiency in complement sufficient mice: C3 consumption occurs without associated renal injury.
Ruseva MM, Hughes TR, Donev RM, Sivasankar B, Pickering MC, Wu X, Harris CL, Morgan BP. Ruseva MM, et al. Among authors: morgan bp. Mol Immunol. 2009 Feb;46(5):803-11. doi: 10.1016/j.molimm.2008.09.003. Epub 2008 Oct 22. Mol Immunol. 2009. PMID: 18947875
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