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In vitro antibacterial activity and mechanism of action of J-111,225, a novel 1beta-methylcarbapenem, against transferable IMP-1 metallo-beta-lactamase producers.
Nagano R, Adachi Y, Hashizume T, Morishima H. Nagano R, et al. J Antimicrob Chemother. 2000 Mar;45(3):271-6. doi: 10.1093/jac/45.3.271. J Antimicrob Chemother. 2000. PMID: 10702544
Synthesis of a key intermediate of novel galbonolide analogues via efficient construction of a conjugated diene system.
Sakoh H, Jona H, Sugimoto Y, Imamura H, Sakuraba S, Yamada K, Morishima H. Sakoh H, et al. Chem Pharm Bull (Tokyo). 2004 Aug;52(8):992-4. doi: 10.1248/cpb.52.992. Chem Pharm Bull (Tokyo). 2004. PMID: 15304999
Synthesis and antifungal activity of novel 14-membered benzomacrolides, as galbonolide analogues.
Sakoh H, Sakuraba S, Sugimoto Y, Imamura H, Jona H, Yamada K, Bamba-Nagano R, Hashizume T, Morishima H. Sakoh H, et al. Chem Pharm Bull (Tokyo). 2004 Jan;52(1):163-5. doi: 10.1248/cpb.52.163. Chem Pharm Bull (Tokyo). 2004. PMID: 14709890
Novel galbonolide derivatives as IPC synthase inhibitors: design, synthesis and in vitro antifungal activities.
Sakoh H, Sugimoto Y, Imamura H, Sakuraba S, Jona H, Bamba-Nagano R, Yamada K, Hashizume T, Morishima H. Sakoh H, et al. Bioorg Med Chem Lett. 2004 Jan 5;14(1):143-5. doi: 10.1016/j.bmcl.2003.09.072. Bioorg Med Chem Lett. 2004. PMID: 14684316
Structure--activity relationships of 1beta-methyl-2-(5-phenylpyrrolidin-3-ylthio)carbapenems.
Sato H, Sakoh H, Hashihayata T, Imamura H, Ohtake N, Shimizu A, Sugimoto Y, Sakuraba S, Bamba-Nagano R, Yamada K, Hashizume T, Morishima H. Sato H, et al. Bioorg Med Chem. 2002 May;10(5):1595-610. doi: 10.1016/s0968-0896(01)00430-8. Bioorg Med Chem. 2002. PMID: 11886821
Diastereoselective synthesis of (2R,4R)-2-aryl-4-hydroxypyrrolidine: preparation of the side chain of novel carbapenem.
Hashihayata T, Sakoh H, Goto Y, Hirose M, Sakuraba S, Imamura H, Sugimoto Y, Yamada K, Morishima H. Hashihayata T, et al. Chem Pharm Bull (Tokyo). 2001 Nov;49(11):1500-2. doi: 10.1248/cpb.49.1500. Chem Pharm Bull (Tokyo). 2001. PMID: 11724250
Practical synthesis of a 1beta-methylcarbapenem, J-111,225, using 4-mercapto-2-[4-(N-methylaminomethyl)phenyl]pyrrolidine as a precursor.
Imamura H, Shimizu A, Sato H, Sugimoto Y, Sakuraba S, Yamada K, Morishima H. Imamura H, et al. Chem Pharm Bull (Tokyo). 2001 Apr;49(4):476-9. doi: 10.1248/cpb.49.476. Chem Pharm Bull (Tokyo). 2001. PMID: 11310678
Discovery of novel trans-3,5-disubstituted pyrrolidinylthio-1beta-methylcarbapenems.
Imamura H, Ohtake N, Shimizu A, Sato H, Sugimoto Y, Sakuraba S, Nagano R, Nakano M, Abe S, Suzuki-Sato C, Nishimura I, Kojima H, Tsuchiya Y, Yamada K, Hashizume T, Morishima H. Imamura H, et al. Bioorg Med Chem. 2000 Aug;8(8):1969-82. doi: 10.1016/s0968-0896(00)00125-5. Bioorg Med Chem. 2000. PMID: 11003142
A novel 1beta-methylcarbapenem, J-111,225: effects of the C-3 and C-5 stereochemistry of the pyrrolidinylthio side chain on antibacterial activities.
Imamura H, Shimizu A, Sato H, Sugimoto Y, Sakuraba S, Nagano R, Yamada K, Hashizume T, Morishima H. Imamura H, et al. J Antibiot (Tokyo). 2000 Mar;53(3):314-6. doi: 10.7164/antibiotics.53.314. J Antibiot (Tokyo). 2000. PMID: 10819306 No abstract available.
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