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Presenilin-dependent intramembrane cleavage of ephrin-B1.
Tomita T, Tanaka S, Morohashi Y, Iwatsubo T. Tomita T, et al. Mol Neurodegener. 2006 Jun 12;1:2. doi: 10.1186/1750-1326-1-2. Mol Neurodegener. 2006. PMID: 16930449 Free PMC article.
Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.
Niimura M, Isoo N, Takasugi N, Tsuruoka M, Ui-Tei K, Saigo K, Morohashi Y, Tomita T, Iwatsubo T. Niimura M, et al. J Biol Chem. 2005 Apr 1;280(13):12967-75. doi: 10.1074/jbc.M409829200. Epub 2005 Jan 11. J Biol Chem. 2005. PMID: 15644323
Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation.
Takahashi Y, Hayashi I, Tominari Y, Rikimaru K, Morohashi Y, Kan T, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T. Takahashi Y, et al. J Biol Chem. 2003 May 16;278(20):18664-70. doi: 10.1074/jbc.M301619200. Epub 2003 Mar 10. J Biol Chem. 2003. PMID: 12637581
Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4.
Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T. Morohashi Y, et al. J Biol Chem. 2002 Apr 26;277(17):14965-75. doi: 10.1074/jbc.M200897200. Epub 2002 Feb 14. J Biol Chem. 2002. PMID: 11847232
The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals.
Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T. Takasugi N, et al. J Biol Chem. 2002 Dec 20;277(51):50198-205. doi: 10.1074/jbc.M205352200. Epub 2002 Oct 17. J Biol Chem. 2002. PMID: 12388554
BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.
Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Young Chang M, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T. Miyagawa T, et al. Among authors: morohashi y. Hum Mol Genet. 2016 Jul 15;25(14):2948-2958. doi: 10.1093/hmg/ddw146. Epub 2016 May 14. Hum Mol Genet. 2016. PMID: 27179792
Protein trafficking and maturation regulate intramembrane proteolysis.
Morohashi Y, Tomita T. Morohashi Y, et al. Biochim Biophys Acta. 2013 Dec;1828(12):2855-61. doi: 10.1016/j.bbamem.2013.06.001. Epub 2013 Jun 11. Biochim Biophys Acta. 2013. PMID: 23770323 Free article. Review.
[Molecular targeted therapy in Alzheimer disease].
Morohashi Y, Tomita T, Iwatsubo T. Morohashi Y, et al. Nihon Rinsho. 2010 Oct;68(10):1906-10. Nihon Rinsho. 2010. PMID: 20954338 Review. Japanese.
Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate.
Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, Tsuji S, Tomita T, Iwatsubo T. Isoo N, et al. J Biol Chem. 2007 Apr 27;282(17):12388-96. doi: 10.1074/jbc.M611549200. Epub 2007 Feb 28. J Biol Chem. 2007. PMID: 17329245
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