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Rapamycin passes the torch: a new generation of mTOR inhibitors.
Benjamin D, Colombi M, Moroni C, Hall MN. Benjamin D, et al. Among authors: moroni c. Nat Rev Drug Discov. 2011 Oct 31;10(11):868-80. doi: 10.1038/nrd3531. Nat Rev Drug Discov. 2011. PMID: 22037041 Review.
The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B.
Schmidlin M, Lu M, Leuenberger SA, Stoecklin G, Mallaun M, Gross B, Gherzi R, Hess D, Hemmings BA, Moroni C. Schmidlin M, et al. Among authors: moroni c. EMBO J. 2004 Dec 8;23(24):4760-9. doi: 10.1038/sj.emboj.7600477. Epub 2004 Nov 11. EMBO J. 2004. PMID: 15538381 Free PMC article.
An isogenic cell panel identifies compounds that inhibit proliferation of mTOR-pathway addicted cells by different mechanisms.
Wyder Peters L, Molle KD, Thiemeyer A, Knopf A, Goxe M, Guerry P, Brodbeck D, Colombi M, Hall MN, Moroni C, Regenass U. Wyder Peters L, et al. Among authors: moroni c. J Biomol Screen. 2014 Jan;19(1):131-44. doi: 10.1177/1087057113497798. Epub 2013 Aug 16. J Biomol Screen. 2014. PMID: 23954931
Syrosingopine sensitizes cancer cells to killing by metformin.
Benjamin D, Colombi M, Hindupur SK, Betz C, Lane HA, El-Shemerly MY, Lu M, Quagliata L, Terracciano L, Moes S, Sharpe T, Wodnar-Filipowicz A, Moroni C, Hall MN. Benjamin D, et al. Among authors: moroni c. Sci Adv. 2016 Dec 23;2(12):e1601756. doi: 10.1126/sciadv.1601756. eCollection 2016 Dec. Sci Adv. 2016. PMID: 28028542 Free PMC article.
c-jun N-terminal kinase is involved in AUUUA-mediated interleukin-3 mRNA turnover in mast cells.
Ming XF, Kaiser M, Moroni C. Ming XF, et al. Among authors: moroni c. EMBO J. 1998 Oct 15;17(20):6039-48. doi: 10.1093/emboj/17.20.6039. EMBO J. 1998. PMID: 9774347 Free PMC article.
SB202190 and wortmannin were shown to antagonize ionomycin-induced IL-3 mRNA stabilization in PB-3c cells in the presence of actinomycin D, and this effect coincided with their ability to inhibit c-jun N-terminal kinase (JNK) activation by ionomycin. ...
SB202190 and wortmannin were shown to antagonize ionomycin-induced IL-3 mRNA stabilization in PB-3c cells in the presence of actinomycin D, …
Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3' untranslated region.
Banholzer R, Nair AP, Hirsch HH, Ming XF, Moroni C. Banholzer R, et al. Among authors: moroni c. Mol Cell Biol. 1997 Jun;17(6):3254-60. doi: 10.1128/mcb.17.6.3254. Mol Cell Biol. 1997. PMID: 9154824 Free PMC article.
Cyclosporin A inhibits growth of autocrine tumour cell lines by destabilizing interleukin-3 mRNA.
Nair AP, Hahn S, Banholzer R, Hirsch HH, Moroni C. Nair AP, et al. Among authors: moroni c. Nature. 1994 May 19;369(6477):239-42. doi: 10.1038/369239a0. Nature. 1994. PMID: 8183344
Modulation of cytokine expression in PB-3c mastocytes by IBMX and PMA.
Hahn S, Moroni C. Hahn S, et al. Among authors: moroni c. Lymphokine Cytokine Res. 1994 Aug;13(4):247-52. Lymphokine Cytokine Res. 1994. PMID: 7528062
Apart from mobilizing calcium, the IgE receptor activation leads to production of DAG and elevation of cAMP levels, thereby activating protein kinases C and A, respectively. ...
Apart from mobilizing calcium, the IgE receptor activation leads to production of DAG and elevation of cAMP levels, thereby activating prote …
Production of the haemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation.
Wodnar-Filipowicz A, Heusser CH, Moroni C. Wodnar-Filipowicz A, et al. Among authors: moroni c. Nature. 1989 May 11;339(6220):150-2. doi: 10.1038/339150a0. Nature. 1989. PMID: 2524008
Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction.
Colombi M, Molle KD, Benjamin D, Rattenbacher-Kiser K, Schaefer C, Betz C, Thiemeyer A, Regenass U, Hall MN, Moroni C. Colombi M, et al. Among authors: moroni c. Oncogene. 2011 Mar 31;30(13):1551-65. doi: 10.1038/onc.2010.539. Epub 2010 Dec 20. Oncogene. 2011. PMID: 21170086
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