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14 results
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Selectively nonselective kinase inhibition: striking the right balance.
Morphy R. Morphy R. J Med Chem. 2010 Feb 25;53(4):1413-37. doi: 10.1021/jm901132v. J Med Chem. 2010. PMID: 20166671 Review. No abstract available.
Designing multiple ligands - medicinal chemistry strategies and challenges.
Morphy R, Rankovic Z. Morphy R, et al. Curr Pharm Des. 2009;15(6):587-600. doi: 10.2174/138161209787315594. Curr Pharm Des. 2009. PMID: 19199984 Review.
Fragments, network biology and designing multiple ligands.
Morphy R, Rankovic Z. Morphy R, et al. Drug Discov Today. 2007 Feb;12(3-4):156-60. doi: 10.1016/j.drudis.2006.12.006. Epub 2006 Dec 14. Drug Discov Today. 2007. PMID: 17275736 Review.
The physicochemical challenges of designing multiple ligands.
Morphy R, Rankovic Z. Morphy R, et al. J Med Chem. 2006 Aug 10;49(16):4961-70. doi: 10.1021/jm0603015. J Med Chem. 2006. PMID: 16884308
The influence of target family and functional activity on the physicochemical properties of pre-clinical compounds.
Morphy R. Morphy R. J Med Chem. 2006 May 18;49(10):2969-78. doi: 10.1021/jm0512185. J Med Chem. 2006. PMID: 16686538
From magic bullets to designed multiple ligands.
Morphy R, Kay C, Rankovic Z. Morphy R, et al. Drug Discov Today. 2004 Aug 1;9(15):641-51. doi: 10.1016/S1359-6446(04)03163-0. Drug Discov Today. 2004. PMID: 15279847 Review.
Designed multiple ligands. An emerging drug discovery paradigm.
Morphy R, Rankovic Z. Morphy R, et al. J Med Chem. 2005 Oct 20;48(21):6523-43. doi: 10.1021/jm058225d. J Med Chem. 2005. PMID: 16220969 Review. No abstract available.
Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Ray P, Wright J, Adam J, Boucharens S, Black D, Brown AR, Epemolu O, Fletcher D, Huggett M, Jones P, Laats S, Lyons A, de Man J, Morphy R, Sherborne B, Sherry L, Straten Nv, Westwood P, York M. Ray P, et al. Among authors: morphy r. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1084-8. doi: 10.1016/j.bmcl.2010.12.104. Epub 2010 Dec 28. Bioorg Med Chem Lett. 2011. PMID: 21251828
Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Ray P, Wright J, Adam J, Bennett J, Boucharens S, Black D, Cook A, Brown AR, Epemolu O, Fletcher D, Haunso A, Huggett M, Jones P, Laats S, Lyons A, Mestres J, de Man J, Morphy R, Rankovic Z, Sherborne B, Sherry L, van Straten N, Westwood P, Zaman GZ. Ray P, et al. Among authors: morphy r. Bioorg Med Chem Lett. 2011 Jan 1;21(1):97-101. doi: 10.1016/j.bmcl.2010.11.060. Epub 2010 Nov 19. Bioorg Med Chem Lett. 2011. PMID: 21145740
Design, synthesis, and structure-activity relationship study of bicyclic piperazine analogs of indole-3-carboxamides as novel cannabinoid CB1 receptor agonists.
Moir EM, Yoshiizumi K, Cairns J, Cowley P, Ferguson M, Jeremiah F, Kiyoi T, Morphy R, Tierney J, Wishart G, York M, Baker J, Cottney JE, Houghton AK, McPhail P, Osprey A, Walker G, Adam JM. Moir EM, et al. Among authors: morphy r. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7327-30. doi: 10.1016/j.bmcl.2010.10.061. Epub 2010 Oct 20. Bioorg Med Chem Lett. 2010. PMID: 21074434
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