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Neuroscience20 (BRAIN20, SPINE20, and MENTAL20) Health Initiative: A Global Consortium Addressing the Human and Economic Burden of Brain, Spine, and Mental Disorders Through Neurotech Innovations and Policies.
Morris K, Nami M, Bolanos JF, Lobo MA, Sadri-Naini M, Fiallos J, Sanchez GE, Bustos T, Chintam N, Amaya M, Strand SE, Mayuku-Dore A, Sakibova I, Biso GMN, DeFilippis A, Bravo D, Tarhan N, Claussen C, Mercado A, Braun S, Yuge L, Okabe S, Taghizadeh-Hesary F, Kotliar K, Sadowsky C, Chandra PS, Tripathi M, Katsaros V, Mehling B, Noroozian M, Abbasioun K, Amirjamshidi A, Hossein-Zadeh GA, Naraghi F, Barzegar M, Asadi-Pooya AA, Sahab-Negah S, Sadeghian S, Fahnestock M, Dilbaz N, Hussain N, Mari Z, Thatcher RW, Sipple D, Sidhu K, Chopra D, Costa F, Spena G, Berger T, Zelinsky D, Wheeler CJ, Ashford JW, Schulte R, Nezami MA, Kloor H, Filler A, Eliashiv DS, Sinha D, DeSalles AAF, Sadanand V, Suchkov S, Green K, Metin B, Hariri R, Cormier J, Yamamoto V, Kateb B. Morris K, et al. J Alzheimers Dis. 2021;83(4):1563-1601. doi: 10.3233/JAD-215190. J Alzheimers Dis. 2021. PMID: 34487051 Review.
Sustained Hippocampal Neural Plasticity Questions the Reproducibility of an Amyloid-β-Induced Alzheimer's Disease Model.
Paulo SL, Ribeiro-Rodrigues L, Rodrigues RS, Mateus JM, Fonseca-Gomes J, Soares R, Diógenes MJ, Solá S, Sebastião AM, Ribeiro FF, Xapelli S. Paulo SL, et al. J Alzheimers Dis. 2021;82(3):1183-1202. doi: 10.3233/JAD-201567. J Alzheimers Dis. 2021. PMID: 34151790
METHODS: Animal behavior was evaluated in the elevated plus maze, Y-Maze spontaneous or forced alternation, Morris water maze, and open field, starting 2 weeks post-Abeta42 infusion. Hippocampal neurogenesis was assessed 3 weeks after Abeta42 injection. ...
METHODS: Animal behavior was evaluated in the elevated plus maze, Y-Maze spontaneous or forced alternation, Morris water maze, and op …
Ameliorating Ribosylation-Induced Amyloid-β Pathology by Berberine via Inhibiting mTOR/p70S6K Signaling.
Wang YY, Yan Q, Huang ZT, Zou Q, Li J, Yuan MH, Wu LQ, Cai ZY. Wang YY, et al. J Alzheimers Dis. 2021;79(2):833-844. doi: 10.3233/JAD-200995. J Alzheimers Dis. 2021. PMID: 33361598
Tissue sections and Immunofluorescence staining were used to observe Abeta42 in APP/PS1 mice hippocampal. Morris water maze test was used to measure the spatial learning and memory of APP/PS1 mice. ...
Tissue sections and Immunofluorescence staining were used to observe Abeta42 in APP/PS1 mice hippocampal. Morris water maze test was …
Presymptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy-Related Blood Metabolite Alterations.
Chatterjee P, Fagan AM, Xiong C, McKay M, Bhatnagar A, Wu Y, Singh AK, Taddei K, Martins I, Gardener SL, Molloy MP, Multhaup G, Masters CL, Schofield PR, Benzinger TLS, Morris JC, Bateman RJ, Greenberg SM, Wermer MJH, van Buchem MA, Sohrabi HR, Martins RN; Dominantly Inherited Alzheimer Network. Chatterjee P, et al. J Alzheimers Dis. 2021;79(2):895-903. doi: 10.3233/JAD-201267. J Alzheimers Dis. 2021. PMID: 33361604 Free PMC article.
Intranasal Paclitaxel Alters Alzheimer's Disease Phenotypic Features in 3xTg-AD Mice.
Cross DJ, Huber BR, Silverman MA, Cline MM, Gill TB, Cross CG, Cook DG, Minoshima S. Cross DJ, et al. J Alzheimers Dis. 2021;83(1):379-394. doi: 10.3233/JAD-210109. J Alzheimers Dis. 2021. PMID: 34308901
METHODS: We administered intranasal PTX in 3XTg-AD mice (3xTg-AD n = 15, 10 weeks and n = 10, 44 weeks, PTX: 0.6 mg/kg or 0.9%saline (SAL)) at 2-week intervals. After treatment, 3XTg-AD mice underwent manganese-enhanced magnetic resonance imaging to measure in vivo axonal …
METHODS: We administered intranasal PTX in 3XTg-AD mice (3xTg-AD n = 15, 10 weeks and n = 10, 44 weeks, PTX: 0.6 mg/kg or 0.9%saline (SAL)) …
DAla2-GIP-GLU-PAL Protects Against Cognitive Deficits and Pathology in APP/PS1 Mice by Inhibiting Neuroinflammation and Upregulating cAMP/PKA/CREB Signaling Pathways.
Yuan L, Zhang J, Guo JH, Holscher C, Yang JT, Wu MN, Wang ZJ, Cai HY, Han LN, Shi H, Han YF, Qi JS. Yuan L, et al. J Alzheimers Dis. 2021;80(2):695-713. doi: 10.3233/JAD-201262. J Alzheimers Dis. 2021. PMID: 33579843
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive decline in cognitive function. Type 2 diabetes mellitus (T2DM) is an important risk factor for AD. Glucose-dependent insulinotropic polypeptide (GIP) has been identified to be …
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive decline in cognitive function. Type 2 …
Clinical and Paraclinical Measures Associated with Outcome in Cerebral Amyloid Angiopathy with Related Inflammation.
Plotzker AS, Henson RL, Fagan AM, Morris JC, Day GS. Plotzker AS, et al. J Alzheimers Dis. 2021;80(1):133-142. doi: 10.3233/JAD-201299. J Alzheimers Dis. 2021. PMID: 33492294 Free PMC article.
RESULTS: Worse outcomes following methylprednisolone treatment were associated with requirement for intensive care unit admission (median deltamRS, 5 versus 1.5; p = 0.048), CSF pleocytosis (median deltamRS 4.5 versus 1; p = 0.04), or lower CSF Abeta40 at presentation (rho = -0.8 …
RESULTS: Worse outcomes following methylprednisolone treatment were associated with requirement for intensive care unit admission (median de …
Communicating 5-Year Risk of Alzheimer's Disease Dementia: Development and Evaluation of Materials that Incorporate Multiple Genetic and Biomarker Research Results.
Mozersky J, Hartz S, Linnenbringer E, Levin L, Streitz M, Stock K, Moulder K, Morris JC. Mozersky J, et al. J Alzheimers Dis. 2021;79(2):559-572. doi: 10.3233/JAD-200993. J Alzheimers Dis. 2021. PMID: 33337371 Free PMC article.
Following material development, 17 CN older adults evaluated the materials for clarity and acceptability (Pilot 2). All participants were community-dwelling older adults participating in longitudinal studies of aging at a single site. ...
Following material development, 17 CN older adults evaluated the materials for clarity and acceptability (Pilot 2). All participants …