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The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism.
Frost G, Sleeth ML, Sahuri-Arisoylu M, Lizarbe B, Cerdan S, Brody L, Anastasovska J, Ghourab S, Hankir M, Zhang S, Carling D, Swann JR, Gibson G, Viardot A, Morrison D, Louise Thomas E, Bell JD. Frost G, et al. Nat Commun. 2014 Apr 29;5:3611. doi: 10.1038/ncomms4611. Nat Commun. 2014. PMID: 24781306 Free PMC article.
Randomised clinical study: inulin short-chain fatty acid esters for targeted delivery of short-chain fatty acids to the human colon.
Polyviou T, MacDougall K, Chambers ES, Viardot A, Psichas A, Jawaid S, Harris HC, Edwards CA, Simpson L, Murphy KG, Zac-Varghese SE, Blundell JE, Dhillo WS, Bloom SR, Frost GS, Preston T, Tedford MC, Morrison DJ. Polyviou T, et al. Among authors: morrison dj. Aliment Pharmacol Ther. 2016 Oct;44(7):662-72. doi: 10.1111/apt.13749. Epub 2016 Jul 28. Aliment Pharmacol Ther. 2016. PMID: 27464984 Free PMC article. Clinical Trial.
93 results